Microdialysis study of biliary excretion of chloramphenicol and its glucuronide in the rat

Journal of Pharmacy and Pharmacology

Volumn 51, Issue 8, 1999, Pages 911-915

  Tsai, T H ^a,b   Hung, L C ^a   Chen, C F ^a  

^a NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORAMPHENICOL HEMISUCCINATE; GLUCURONIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BILE DUCT; BILIARY EXCRETION; COMPARTMENT MODEL; CONTROLLED STUDY; DRUG DISPOSITION; DUODENUM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; LIVER; MALE; MICRODIALYSIS; NONHUMAN; RAT;

EID: 0032865230     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/0022357991773339     Document Type: Article

References (17)

1. Bories, G. F., Peleran, J. C., Wal, J. M., Corpet, D. E. (1983) Simple and ion-pair high-performance liquid chromatography as an improved analytical tool for chloramphenicol metabolic profiling. Drug Metab. Dispos. 11: 249-254
2. Cravedi, J. P., Baradat, M., Debrauwer, L., Alary, J., Tulliez, J., Bories, G. (1994) Evidence for new metabolic pathways of chloramphenicol in the duck. Drug Metab. Dispos. 22: 578-583
3. Gibaldi, M., Perrier, D. (1982) Pharmacokinetics, 2nd edn, Marcel Dekker, New York
4. Glazko, A. J., Wolf, L. M., Dill, W. A., Bratton, A. C. (1949) Biochemical studies on chloramphenicol. II. Tissue distribution and excretion studies. J. Pharmacol. Exp. Ther. 96: 445-459
5. Glazko, A. J., Dill, W. A., Rebstock, M. C. (1950) Biochemical studies on chloramphenicol (chloromycetin). III. Isolation and identification of metabolic products in urine. J. Biol. Chem. 183: 679-691
6. Glazko, A. J., Dill, W. A., Wolf, L. M. (1952) Observations on the metabolic disposition of chloramphenicol (chloromycetin) in the rat. J. Pharmacol. Exp. Ther. 104: 452-458
7. Hadwiger, M. E., Telting-Diaz, M., Lunte, C. E. (1994) Liquid Chromatographic determination of tacrine and its metabolites in rat bile microdialysates. J. Chromatogr. B. 655: 235-241
8. Holt, D. E., Hurley, R., Harvey, D. (1995) A reappraisal of chloramphenicol metabolism: detection and quantification of metabolites in the sera of children. J. Antimicrob. Chemother. 35: 115-127
9. Hummert, C., Luckas, B., Siebenlist, H. (1995) Determination of chloramphenicol in animal tissue using high-performance liquid chromatography with a column-switching system and ultraviolet detection. J. Chromatogr. B. 668: 53-58
10. Johansen, M. J., Newman, R. A., Madden, T. (1997) The use of microdialysis in pharmacokinetics and pharmacodynamics. Pharmacotherapy 17: 464-481
11. Kates, R. E., Tozer, T. N. (1976) Biliary secretion of methotrexate in rats and its inhibition by probenecid. J. Pharm. Sci. 65: 1348-1352
12. Nahata, M. C., Powell, D. A. (1981) Bioavailability and clearance of chloramphenicol after intravenous chloramphenicol succinate. Clin. Pharmacol. Ther. 30: 368-372
13. Scott, D. O., Lunte, C. E. (1993) In vivo microdialysis sampling in the bile, blood, and liver of rats to study the disposition of phenol. Pharm. Res. 10: 335-342
14. Tsai, T. H., Cheng, F. C., Hung, L. C., Chen, C. F. (1998) Online microdialysis coupled with microbore liquid chromatography for the determination of unbound chloramphenicol and its glucuronide in rat blood. J. Chromatogr. B. 720: 165-169
15. Uesugi, T., Ikeda, M., Hori, R., Katayama, K., Arita, T. (1974a) Metabolism of triamphenicol and comparative studies of its urinary and biliary excretion with chloramphenicol in various species. Chem. Pharm. Bull. 22: 2714-2722
16. Uesugi, T., Ikeda, M., Kanei, Y. (1974b) Studies on the biliary excretion mechanisms of drugs. III. Active transport of glucuronides into bile in rats. Chem. Pharm. Bull. 22: 433-438
17. Wal, J. M., Peleran, J. C., Bories, G. F. (1980) Identification of chloramphenicol oxamic acid as a new major metabolite of chloramphenicol in rats. FEBS Lett. 119: 38-42