메뉴 건너뛰기




Volumn 63, Issue 3, 1999, Pages 163-170

The influence of interferon-α on the pharmacokinetics of cyclophosphamide and its 4-hydroxy metabolite in patients with multiple myeloma

Author keywords

4 hydroxycyclophosphamide; Cyclophosphamide; Interferon ; Multiple myeloma; Pharmacokinetics

Indexed keywords

4 HYDROXYCYCLOPHOSPHAMIDE; ALPHAN1 INTERFERON; CYCLOPHOSPHAMIDE;

EID: 0032865199     PISSN: 09024441     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0609.1999.tb01764.x     Document Type: Article
Times cited : (20)

References (37)
  • 1
    • 15444352201 scopus 로고    scopus 로고
    • Relevance of age on survival of 341 patients with multiple myeloma treated with conventional chemotherapy: Updated results of the MM87 prospective randomized protocol
    • Cooperative Group of Study and Treatment of Multiple Myeloma
    • RICCARDI A, MORA O, BRUGNATELLI S, et al. Relevance of age on survival of 341 patients with multiple myeloma treated with conventional chemotherapy: updated results of the MM87 prospective randomized protocol. Cooperative Group of Study and Treatment of Multiple Myeloma. Br J Cancer 1998;77:485-491.
    • (1998) Br J Cancer , vol.77 , pp. 485-491
    • Riccardi, A.1    Mora, O.2    Brugnatelli, S.3
  • 3
    • 0026100542 scopus 로고
    • Clinical pharmacokinetics of cyclophosphamide
    • MOORE MJ. Clinical pharmacokinetics of cyclophosphamide. Clin Pharmacokinet 1991;20:194-208.
    • (1991) Clin Pharmacokinet , vol.20 , pp. 194-208
    • Moore, M.J.1
  • 4
    • 0026748897 scopus 로고
    • Cyclophosphamide pharmacokinetics: Correlation with cardiac toxicity and tumor response
    • AYASH LJ, WRIGHT JE, TREIYAKOV O, et al. Cyclophosphamide pharmacokinetics: correlation with cardiac toxicity and tumor response. J Clin Oncol 1992;10:995-1000.
    • (1992) J Clin Oncol , vol.10 , pp. 995-1000
    • Ayash, L.J.1    Wright, J.E.2    Treiyakov, O.3
  • 5
    • 0018934513 scopus 로고
    • Bladder cancer following administration of cyclophosphamide
    • DURKEE C, BENSON R, Jr. Bladder cancer following administration of cyclophosphamide. Urology 1980;16:145-148.
    • (1980) Urology , vol.16 , pp. 145-148
    • Durkee, C.1    Benson R., Jr.2
  • 6
    • 0020070463 scopus 로고
    • Conversion of 4-hydroperoxycyclophosphamide and 4-hydroxycyclophosphamide to phosphoramide mustard and acrolein mediated by bifunctional catalysis
    • LOW JE, BORCH RF, SLADEK NE. Conversion of 4-hydroperoxycyclophosphamide and 4-hydroxycyclophosphamide to phosphoramide mustard and acrolein mediated by bifunctional catalysis. Cancer Res 1982;42:830-837.
    • (1982) Cancer Res , vol.42 , pp. 830-837
    • Low, J.E.1    Borch, R.F.2    Sladek, N.E.3
  • 7
    • 0021129862 scopus 로고
    • Half-life of oxazaphosphorines in biological fluids
    • SLADEK NE, POWERS JF, GRAGE GM. Half-life of oxazaphosphorines in biological fluids. Drug Metab Dispos 1984;12:553-559.
    • (1984) Drug Metab Dispos , vol.12 , pp. 553-559
    • Sladek, N.E.1    Powers, J.F.2    Grage, G.M.3
  • 8
    • 0029863162 scopus 로고    scopus 로고
    • Conditioning regimen-dependent disposition of cyclophosphamide and hydroxycyclophosphamide in human marrow transplantation patients
    • SLATTERY JT, KALHORN TF, MCDONALD GB, et al. Conditioning regimen-dependent disposition of cyclophosphamide and hydroxycyclophosphamide in human marrow transplantation patients. J Clin Oncol 1996;14:1484-1494.
    • (1996) J Clin Oncol , vol.14 , pp. 1484-1494
    • Slattery, J.T.1    Kalhorn, T.F.2    McDonald, G.B.3
  • 9
    • 0029958848 scopus 로고    scopus 로고
    • Lack of relationship between systemic exposure for the component drug of the fluorouracil, epirubicin, and 4-hydroxycyclophosphamide regimen in breast cancer patients
    • SANDSTROM M, FREUS A, LARSSON R, et al. Lack of relationship between systemic exposure for the component drug of the fluorouracil, epirubicin, and 4-hydroxycyclophosphamide regimen in breast cancer patients. J Clin Oncol 1996;14:1581-1588.
    • (1996) J Clin Oncol , vol.14 , pp. 1581-1588
    • Sandstrom, M.1    Freus, A.2    Larsson, R.3
  • 10
    • 0023262622 scopus 로고
    • Plasma pharmacokinetics of cyclophosphamide and its cytotoxic metabolites after intravenous vs. oral administration in a randomized, crossover trial
    • STRUCK RF, ALBERTS DS, HORNE K, PHILLIPS JG, PENG YM, ROE DJ. Plasma pharmacokinetics of cyclophosphamide and its cytotoxic metabolites after intravenous vs. oral administration in a randomized, crossover trial. Cancer Res 1987;47:2723-2726.
    • (1987) Cancer Res , vol.47 , pp. 2723-2726
    • Struck, R.F.1    Alberts, D.S.2    Horne, K.3    Phillips, J.G.4    Peng, Y.M.5    Roe, D.J.6
  • 11
    • 0027369366 scopus 로고
    • Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes
    • CHANG TK, WEBER GF, CRESPI CL, WAXMAN DJ. Differential activation of cyclophosphamide and ifosphamide by cytochromes P-450 2B and 3A in human liver microsomes. Cancer Res 1993;53:5629-5637.
    • (1993) Cancer Res , vol.53 , pp. 5629-5637
    • Chang, T.K.1    Weber, G.F.2    Crespi, C.L.3    Waxman, D.J.4
  • 13
    • 0023638209 scopus 로고
    • Repeated high-dose cyclophosphamide administration in bone marrow transplantation: Exposure to activated metabolites
    • SCHULER U, EHNINGER G, WAGNER T. Repeated high-dose cyclophosphamide administration in bone marrow transplantation: exposure to activated metabolites. Cancer Chemother Pharmacol 1987;20:248-252.
    • (1987) Cancer Chemother Pharmacol , vol.20 , pp. 248-252
    • Schuler, U.1    Ehninger, G.2    Wagner, T.3
  • 14
    • 0028890757 scopus 로고
    • Cyclophosphamide metabolism in children
    • YULE SM, BODDY AV, COLE M, et al. Cyclophosphamide metabolism in children. Cancer Res 1995;55:803-809.
    • (1995) Cancer Res , vol.55 , pp. 803-809
    • Yule, S.M.1    Boddy, A.V.2    Cole, M.3
  • 15
    • 0021747656 scopus 로고
    • Positive interactions between interferon and chemotherapy due to direct tumor action rather than effects on host drugmetabolizing enzymes
    • BALKWILL FR, MOWSHOWITZ S, SEILMAN SS, et al. Positive interactions between interferon and chemotherapy due to direct tumor action rather than effects on host drugmetabolizing enzymes. Cancer Res 1984;44:5249-5255.
    • (1984) Cancer Res , vol.44 , pp. 5249-5255
    • Balkwill, F.R.1    Mowshowitz, S.2    Seilman, S.S.3
  • 16
    • 0023096792 scopus 로고
    • Interferons in the treatment of multiple myeloma
    • COOPER MR, WELANDER CE. Interferons in the treatment of multiple myeloma. Cancer 1987;59(Suppl):594-600.
    • (1987) Cancer , vol.59 , Issue.SUPPL. , pp. 594-600
    • Cooper, M.R.1    Welander, C.E.2
  • 18
    • 0029005703 scopus 로고
    • Interferon-alpha for induction and maintenance in multiple myeloma: Results of two multicenter randomized trials and summary of other studies
    • LUDWIG H, COHEN AM, POLLIACK A, et al. Interferon-alpha for induction and maintenance in multiple myeloma: results of two multicenter randomized trials and summary of other studies. Ann Oncol 1995;6:467-476.
    • (1995) Ann Oncol , vol.6 , pp. 467-476
    • Ludwig, H.1    Cohen, A.M.2    Polliack, A.3
  • 19
    • 0022982158 scopus 로고
    • Interferon alfa-2b-cyclophosphamide combination studies: In vitro and phase I-II clinical results
    • DURIF BG, CLOUSE L, BRAICH T, GRIMM M, ROBERTONE AB. Interferon alfa-2b-cyclophosphamide combination studies: in vitro and phase I-II clinical results. Semin Oncol 1986;13(Suppl 2):84-88.
    • (1986) Semin Oncol , vol.13 , Issue.SUPPL. 2 , pp. 84-88
    • Durif, B.G.1    Clouse, L.2    Braich, T.3    Grimm, M.4    Robertone, A.B.5
  • 20
    • 0016804136 scopus 로고
    • A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival
    • DURIE BG, SALMON SE. A clinical staging system for multiple myeloma. Correlation of measured myeloma cell mass with presenting clinical features, response to treatment, and survival. Cancer 1975;36:842-854.
    • (1975) Cancer , vol.36 , pp. 842-854
    • Durie, B.G.1    Salmon, S.E.2
  • 21
    • 0021187214 scopus 로고
    • High-performance liquid chromatographic measurement of cyclophosphamide in serum
    • HARDY RW, ERLICHMAN C, SOLDIN SJ. High-performance liquid chromatographic measurement of cyclophosphamide in serum. Ther Drug Monit 1984;6:313-318.
    • (1984) Ther Drug Monit , vol.6 , pp. 313-318
    • Hardy, R.W.1    Erlichman, C.2    Soldin, S.J.3
  • 22
    • 0028170927 scopus 로고
    • Determination of 4-hydroxycyclophosphamide in plasma, us 2,4- dinitrophenylhydrazone derivative of aldophosphamide, by liquid chromatography
    • JOHANSSON M, BIELENSTEIN M. Determination of 4-hydroxycyclophosphamide in plasma, us 2,4- dinitrophenylhydrazone derivative of aldophosphamide, by liquid chromatography. J Chromatogr B Biomed Appl 1994;660:111-120.
    • (1994) J Chromatogr B Biomed Appl , vol.660 , pp. 111-120
    • Johansson, M.1    Bielenstein, M.2
  • 23
    • 0027394227 scopus 로고
    • Natural interferon-alpha in combination with melphalan/prednisone vs. melphalan/prednisone in the treatment of multiple myeloma stages II and III: A randomized study from the Myeloma Group of Central Sweden
    • OSTERBORG A, BJORKHOLM M, BJOREMAN M, et al. Natural interferon-alpha in combination with melphalan/prednisone vs. melphalan/prednisone in the treatment of multiple myeloma stages II and III: a randomized study from the Myeloma Group of Central Sweden. Blood 1993;81:1428-1434.
    • (1993) Blood , vol.81 , pp. 1428-1434
    • Osterborg, A.1    Bjorkholm, M.2    Bjoreman, M.3
  • 24
    • 0027447339 scopus 로고
    • A randomized clinical trial comparing melphalan/prednisone with or without interferon alfa-2b in newly diagnosed patients with multiple myeloma: A cancer and leukemia group B study
    • COOPER MR, DEAR K, MCINTYRE OR, et al. A randomized clinical trial comparing melphalan/prednisone with or without interferon alfa-2b in newly diagnosed patients with multiple myeloma: a Cancer and Leukemia Group B study. J Clin Oncol 1993;11:155-160.
    • (1993) J Clin Oncol , vol.11 , pp. 155-160
    • Cooper, M.R.1    Dear, K.2    McIntyre, O.R.3
  • 25
    • 0021167354 scopus 로고
    • Plasma concentrations of 4-hydroxycyclophosphamide and phosphoramide mustard in patients repeatedly given high doses of cyclophosphamide in preparation for bone marrow transplantation
    • SLADEK NE, DOEDEN D, POWERS JF, KRIVET W. Plasma concentrations of 4-hydroxycyclophosphamide and phosphoramide mustard in patients repeatedly given high doses of cyclophosphamide in preparation for bone marrow transplantation. Cancer Treat Rep 1984;68:1247-1254.
    • (1984) Cancer Treat Rep , vol.68 , pp. 1247-1254
    • Sladek, N.E.1    Doeden, D.2    Powers, J.F.3    Krivet, W.4
  • 26
    • 0026026522 scopus 로고
    • Pharmacokinetics of 4-hydroxycyclophosphamide and metabolites in the rat
    • HONG PS, SRIGRITSANAPOL A, CHAN KK. Pharmacokinetics of 4-hydroxycyclophosphamide and metabolites in the rat. Drug Metab Dispos 1991;19:1-7.
    • (1991) Drug Metab Dispos , vol.19 , pp. 1-7
    • Hong, P.S.1    Srigritsanapol, A.2    Chan, K.K.3
  • 27
    • 0030916085 scopus 로고    scopus 로고
    • Nonlinear pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide/aldophosphamide in patients with metastatic breast cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation
    • CHEN TL, KENNEDY MJ, ANDERSON LW, et al. Nonlinear pharmacokinetics of cyclophosphamide and 4-hydroxycyclophosphamide/aldophosphamide in patients with metastatic breast cancer receiving high-dose chemotherapy followed by autologous bone marrow transplantation. Drug Metab Dispos 1997;25:544-551.
    • (1997) Drug Metab Dispos , vol.25 , pp. 544-551
    • Chen, T.L.1    Kennedy, M.J.2    Anderson, L.W.3
  • 28
    • 0030951908 scopus 로고    scopus 로고
    • Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: Response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines
    • CHANG TK, YU L, MAUREL P, WAXMAN DJ. Enhanced cyclophosphamide and ifosfamide activation in primary human hepatocyte cultures: response to cytochrome P-450 inducers and autoinduction by oxazaphosphorines. Cancer Res 1997;57:1946-1954.
    • (1997) Cancer Res , vol.57 , pp. 1946-1954
    • Chang, T.K.1    Yu, L.2    Maurel, P.3    Waxman, D.J.4
  • 29
    • 0027284901 scopus 로고
    • Modulation of rat hepatic CYP3A1 induction by the interferon inducer polyinosinic acid-polycytidylic acid (polyic)
    • DELAPORTE E, CRIBB AE, RENTON KE. Modulation of rat hepatic CYP3A1 induction by the interferon inducer polyinosinic acid-polycytidylic acid (polyic). Drug Metab Dispos 1993;21:520-523.
    • (1993) Drug Metab Dispos , vol.21 , pp. 520-523
    • Delaporte, E.1    Cribb, A.E.2    Renton, K.E.3
  • 30
    • 0029022894 scopus 로고
    • The duration of induction and species influences the downregulation of cytochrome P450 by the interferon inducer polyinosinic acid- polycytidylic acid
    • ANARI MR, CRIBB AE, RENTON KW. The duration of induction and species influences the downregulation of cytochrome P450 by the interferon inducer polyinosinic acid- polycytidylic acid. Drug Metab Dispos 1995;23:536-541.
    • (1995) Drug Metab Dispos , vol.23 , pp. 536-541
    • Anari, M.R.1    Cribb, A.E.2    Renton, K.W.3
  • 31
    • 0023230059 scopus 로고
    • Inhibition of theophylline metabolism by interferon
    • WILLIAMS SJ, BAIRD-LAMBERT JA, FARRELL GC. Inhibition of theophylline metabolism by interferon. Lancet 1987;2:939-941.
    • (1987) Lancet , vol.2 , pp. 939-941
    • Williams, S.J.1    Baird-Lambert, J.A.2    Farrell, G.C.3
  • 33
    • 0028096113 scopus 로고
    • Detoxification of cyclophosphamide by human aldehyde dehydrogenase isozymes
    • VON EITZEN U, MEIER-TACKMANN D, AGARWAL DP, GOEDDE HW. Detoxification of cyclophosphamide by human aldehyde dehydrogenase isozymes. Cancer Lett 1994;76:45-49.
    • (1994) Cancer Lett , vol.76 , pp. 45-49
    • Von Eitzen, U.1    Meier-Tackmann, D.2    Agarwal, D.P.3    Goedde, H.W.4
  • 34
    • 0026448886 scopus 로고
    • Individual variation in the activation and inactivation of metabolic pathways of cyclophosphamide
    • [see comments]
    • BODDY AV, FURTUN Y, SARDAS S, SARDAS O, IDLE JR. Individual variation in the activation and inactivation of metabolic pathways of cyclophosphamide [see comments]. J Natl Cancer Inst 1992;84:1744-1748.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 1744-1748
    • Boddy, A.V.1    Furtun, Y.2    Sardas, S.3    Sardas, O.4    Idle, J.R.5
  • 35
    • 0023814716 scopus 로고
    • Phenotypically deficient urinary, elimination of carboxyphosphamide after cyclophosphamide administration to cancer patients
    • HADIDI AH, COULTER CE, IDLE JR. Phenotypically deficient urinary, elimination of carboxyphosphamide after cyclophosphamide administration to cancer patients. Cancer Res 1988;48:5167-5171.
    • (1988) Cancer Res , vol.48 , pp. 5167-5171
    • Hadidi, A.H.1    Coulter, C.E.2    Idle, J.R.3
  • 36
    • 0026907527 scopus 로고
    • Molecular genetics of human aldehyde dehydrogenase
    • YOSHIDA A. Molecular genetics of human aldehyde dehydrogenase. Pharmacogenetics 1992;2:139-147.
    • (1992) Pharmacogenetics , vol.2 , pp. 139-147
    • Yoshida, A.1
  • 37
    • 0028336681 scopus 로고
    • Hepatic and serologic toxicity of systemic interleukin-2 and/or interferon-alpha. Evidence of a risk-benefit advantage of subcutaneous therapy
    • SCHOMBURG A, KIRCHNER H, LOPEZ-HANNINEN E, et al. Hepatic and serologic toxicity of systemic interleukin-2 and/or interferon-alpha. Evidence of a risk-benefit advantage of subcutaneous therapy. Am J Clin Oncol 1994;17:199-209.
    • (1994) Am J Clin Oncol , vol.17 , pp. 199-209
    • Schomburg, A.1    Kirchner, H.2    Lopez-Hanninen, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.