Gas chromatography-mass spectrometry analysis of organic acids: Altered quantitative response for aqueous calibrators and dilute urine specimens

Clinical Chemistry

Volumn 45, Issue 8 I, 1999, Pages 1297-1300

  Kumps, Alain ^a   Duez, Pierre ^a   Genin, Janine ^a   Mardens, Yves ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOGLUTARIC ACID; 3 HYDROXYBUTYRIC ACID; ARYLBUTYRIC ACID DERIVATIVE; CARBOXYLIC ACID; GLUTARIC ACID DERIVATIVE; GLYCINE DERIVATIVE; GLYCOLIC ACID; GLYOXYLIC ACID; HEXANOIC ACID DERIVATIVE; ISOVALERIC ACID; LACTIC ACID; PHENYLPYRUVIC ACID; PYRUVIC ACID; UNDECANOIC ACID; VALERIC ACID DERIVATIVE;

AQUEOUS SOLUTION; ARTICLE; CALIBRATOR; CONTROLLED STUDY; CREATININE URINE LEVEL; DERIVATIZATION; DILUTION; EXTRACTION; GAS CHROMATOGRAPHY; HUMAN; MASS SPECTROMETRY; QUANTITATIVE ASSAY; STANDARD; URINALYSIS;

EID: 0032865022     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/45.8.1297     Document Type: Article

References (5)

1. Sweetman L. Organic acid analysis. In: Hommes FA, ed. Techniques in diagnostic human biochemical genetics. A laboratory manual. New York: Wiley-Liss, 1991:143-76.
2. Duez P, Kumps A, Mardens Y. GC-MS profiling of urinary organic acids evaluated as a quantitative method. Clin Chem 1996;42:1609-15.
3. Mardens Y, Kumps A, Duez P. Quantification of urinary organic acids analyzed by gas chromatography mass spectrometry (GCMS). Sixth International Congress on Inborn Errors of Metabolism, Milan, Italy, May 27-31, 1994.
4. Finar IL, ed. Organic chemistry 1: the fundamental principles. London: Longmans, 1967:966 pp.
5. Chalmers RA, Lawson AM, Watts RWE. Extraction of urinary organic acids by combined barium salt precipitation anion exchange [Reply to Letter]. Clin Chem 1977;23:903-8.