New potent sensitizers for photodynamic therapy: 21-oxaporphyrin, 21- thiaporphyrin and 21,23-dithiaporphyrin induce extensive tumor necrosis

Journal of Cancer Research and Clinical Oncology

Volumn 125, Issue 10, 1999, Pages 563-568

  Ziółkowski, Piotr ^a   Symonowicz, Krzysztof ^a   Chmielewski, Piotr ^b   Latos Grazyński, Lechosław ^b   Streckyte, Giedre ^c   Rotomskis, Ricardas ^c   Rabczyński, Jerzy ^a  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b UNIVERSITY OF WROC AW   (Poland)

^c VILNIUS UNIVERSITY   (Lithuania)

Author keywords

21,23 Dithiaporphyrin; 21 Oxaporphyrin; 21 Thiaporphyrin; Mouse fibrosarcoma BFS1; Photodynamic therapy

Indexed keywords

21 OXAPORPHYRIN; 21 THIAPORPHYRIN; 21,23 DITHIAPORPHYRIN; PHOTOSENSITIZING AGENT; PORPHYRIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER GRAFT; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; FIBROSARCOMA; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOSENSITIVITY; PRIORITY JOURNAL; TUMOR NECROSIS;

ANIMALS; FIBROSARCOMA; MICE; MICE, INBRED BALB C; NECROSIS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PORPHYRINS; SKIN; SURVIVAL ANALYSIS; TIME FACTORS;

EID: 0032864308     PISSN: 01715216     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004320050317     Document Type: Article

References (25)

1. Baumgartner R, Fuchs N, Jocham D, Stepp H, Unsoeld E (1992) Pharmacokinetics of fluorescent polyporphyrin Photofrin II in normal rat tissue and rat bladder tumor. Photochem Photobiol 55:569-574
2. Bellnier DA, Dougherty TJ (1989) Protection of murine foot tissue and transplantable tumor against Photofrin II-mediated photodynamic sensitization with WR-2721. J Photochem Photobiol [B] 4:219-225
3. Bellnier DA, Ho YK, Pandey RK, Missert JR, Dougherty TJ (1989) Distribution and elimination of Photofrin II in mice. Photochem Photobiol 50:221-228
4. Bonnett R (1995) Photosensitizers of the porphyrin and phthalocyanine series for photodynamic therapy. Chem Soc Rev 19-33
5. Bonnett R, Nizhnik AN, White SG, Berenbaum MC (1990) Porphyrin sensitizers in tumour phototherapy. Novel sensitizers of the chlorin and bacteriochlorin class with amphiphilic properties. J Photochem Photobiol [B] 6:29-37
6. Dougherty TJ (1987) Photosensitizers: therapy and detection of malignant tumors. Photochem Photobiol 45:879-889
7. Dougherty TJ, Kaufman JE, Goldfarb A, Weishaupt KR, Boyle DG, Mittelman A (1978) Photoradiation therapy for the treatment of malignant tumors. Cancer Res 38:2628-2635
8. Ginevra F, Biffanti S, Pagnan A, Biolo R, Reddi E, Jori G (1990) Delivery of the tumor photosensitizers zinc (II) Pc to serum proteins by different liposomes: Studies in vitro and in vivo. Cancer Lett 49:59-65
9. Jori G (1996) Tumour photosensitizers: Approaches to enhance the selectivity and efficiency of photodynamic therapy. J Photochem Photobiol [B] 36:87-93
10. Kostenich GA, Zhuravkin IN, Furmanchuk AV, Zhavrid EA (1991) Photodynamic therapy with chlorin e6. A morphologic study of tumor damage efficiency in experiment. J Photochem Photobiol [B] 11:307-318
11. Latos-Grażyński L, Lisowski J, Olmstead MM, Balch AL (1989) Five-coordinate complexes of 21-thiaporphyrin. The preparation, spectra and structures of iron (II), nickel (II) and copper (II) complexes. Inorg Chem 28:1183-1188
12. Latos-Grażyński L, Lisowski J, Szterenberg L, Olmstead MM, Balch AL (1991) Crystal and molecular structure of 21-thia-5,20-diphenyl-10,15-di-(p.-nitrophenyl)porphyrin and 21,23-dithiatetraphenyl porphyrin. J Org Chem 56:4043-4045
13. Latos-Grażyński L, Pacholska E, Chmielewski PJ, Olmstead MM, Balch AL (1994) Alteration of the reactivity of a tellurophene within a core-modified porphyrin environment: Synthesis and oxidation of 21-telluraporphyrin. Angew. Chem Int Ed Engl 33:779-781
14. Marcinkowska E, Ziółkowski P, Pacholska E, Latos-Grażyński L, Chmielewski P, Radzikowski Cz (1997) The new sensitizing agents for photodynamic therapy: 21-selenaporphyrin and 21-thiaporphyrin. Anticancer Res 17:3313-3320
15. Margolis-Nunno H, Ben-Hur E, Gottlieb P, Robinson R, Oetjen J, Horowitz B (1996) Inactivation by phthalocyanine photosensitization of multiple forms of human immunodeficiency virus in red cell concentrates. Transfusion 36:743-750
16. Pandian RP, Chandrashekar TK (1993) Water soluble 21-thiaporphyrins and metallo-21-thiaporphyrins; synthesis, characterization, ground- and excited state properties. J Chem Soc Dalton Trans 119-125
17. Peng Q, Moan J, Warloe T, Nesland JM, Rimington C (1992) Distribution and photosensitizing efficiency of porphyrins induced by application of exogenous 5-aminolevulinic acid in mice bearing mammary carcinoma. Int J Cancer 52:433-443
18. Ris HB, Altermatt HJ, Inderbitzi R, Hess R, Nachbur B, Stewart JCM, Wang Q, Lim CK, Bonnett R, Berenbaum MC, Althaus U (1991) Photodynamic therapy with chlorins for diffuse malignant mesothelioma: Initial clinical results. Br J Cancer 64:1116-1120
19. Ris HB, Altermatt HJ, Stewart CM, Schaffner T, Wang Q, Lim CK, Bonnett R, Althaus U (1993) Photodynamic therapy with tetra(hydroxyphenyl)chlorin in vivo: Optimization of the therapeutic index. Int J Cancer 55:245-249
20. Spikes JD (1990) Chlorins as photosensitizers in biology and medicine. J Photochem Photobiol [B] 6:259-274
21. Spikes JD, Bommer JC (1993) Photosensitizing properties of mono-L-aspartyl chlorin e6 (NPe6): A candidate sensitizer for the photodynamic therapy of tumors. J Photochem Photobiol [B] 17:135-143
22. Strizhak P, Kriska T, Gal D (1996) Mechanism of in vivo photodynamic effects. Proc SPIE (Int Soc Opt Eng) 2625:356-368
23. Tralau CJ, Barr H, Sandeman DR, Barton T, Lewin MR, Bown SG (1987) Aluminium sulphonated phthalocyanine distribution in rodent tumours of the colon, brain and pancreas. Photochem Photobiol 46:777-781
24. Weinstein GD, MacCullough JL, Nelson JS, Berns MW (1991) Low dose Photofrin II photodynamic therapy of psoriasis. J Invest Dermatol 96:573
25. Ziółkowski P, Milach J, Symonowicz K, Chmielewski P, Latos-Grażyński L, Marcinkowska E (1995) 5,20-Bis(4-sulphophe-nyl)-10,15-bis(2-methoxy-4-sulphophenyl)-21-thiaporphyrin as a new potent sensitizer in photodynamic therapy. Tumori 81:364-369