Skin organ culture for cutaneous irritancy screening

In Vitro and Molecular Toxicology: Journal of Basic and Applied Research

Volumn 12, Issue 2, 1999, Pages 77-82

  Jung, Sangwook ^a   Park, Mungok ^a   Kim, Jinjun ^a   Kang, Sehhun ^a  

^a LG Household and Healthcare Ltd   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANIONIC SURFACTANT; CATIONIC SURFACTANT; COSMETIC; DODECYL SULFATE SODIUM; EDETIC ACID; IRRITANT AGENT; MYRISTIC ACID ISOPROPYL ESTER; NONIONIC SURFACTANT; OIL; PALMITIC ACID ISOPROPYL ESTER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL VIABILITY; COMPARTMENT MODEL; CONTROLLED STUDY; DOSE RESPONSE; MOUSE; NONHUMAN; ORGAN CULTURE; SCREENING TEST; SKIN IRRITATION; SKIN MANIFESTATION; SKIN TEST;

EID: 0032863333     PISSN: 10979336     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. AUGUSTIN, C., COLLOMBEL, C., and DAMOUR, O. (1997). Use of dermal equivalent and skin equivalent models for identifying phototoxic compounds in vitro. Photoderm. Photoimmunol Photomed. 13:27-36.
2. AUGUSTIN, C., and DAMOUR, O. (1995). Development of kit for predicting cutaneous toxicity in vitro using three-dimensional dermal equivalent: phase reproducibility of dermal equivalent. Cell. Eng. Ing. Mol. Eng. I:58-62.
3. BARTNIK, F.G., PITTERMANN, W.F., MENDORF, N., TILLMAN, U., and KUNSTLER, K. (1990). Skin organ culture for the study of skin irritancy. Toxicol. In Vitro 4, 293-301.
4. BORENFREUND, E., BABICH, H., and MARTIN-ALGUACIL, N. (1988). Comparisons of two in vitro cytotoxicity assays-the neutral red (NR) and tetrazolium MTT tests. Toxicol. In Vitro 2(1), 1-6.
5. DRAIZE, J.H., WOODARD, G., and CALVERY, H.O. (1944). Methods for the study of irritation and toxicity of substances applied topically to the skin and mucous membranes. J. Pharmacol. Exp. Ther. 82, 377-390.
6. FRANCOIS, D., and RITA, L. (1986). Rapid colorimetric assay for cell growth and survival Modifications to the tetrazolium dye processing giving improved sensitivity and reliability. J. Immunol. Methods 89, 271-277.
7. HARVELL, J.D., TSAI, Y.-C., MAIBACH, H.I., et al. (1994) An in vivo correlation with three in vitro assays to assess skin irritation potential. J. Toxicol. Cut. Ocular Toxicol. 13(2), 171-183.
8. INVITTOX protocol 103 (1994). Cutaneous toxicity testing using skin organ culture.
9. KAO, J., HALL, J., and HOLLAND, J.M. (1983). Quantitation of cutaneous toxicity: An in vitro approach using skin organ culture. Toxicol. Appl. Pharmacol. 68, 206-217.
10. MOSSMAN, T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods 65, 55-63.
11. OECD (1993). OECD Guidelines for the testing of chemicals. Section 4, 404.
12. OHNO, Y., KANEKO, T., and KOBAYASHI, T., et al. (1994). First-phase validation of the in vitro eye irritation tests for cosmetic ingredients. In Vitro Toxicol. 7(2), 89-94.
13. RUTTEN, A.A.J.J.L., BEQUET-PASSELECQ, B.G.A.G.G., and KOETER, H.B.W.M. (1990). Two-compartment model for rabbit skin organ culture. In Vitro Cell. Dev. Biol. 25, 353-360.
14. THOMAS, H., KORTING, H.C., and MAIBACH, H.I. (1995). Assessment of cutaneous and ocular irritancy: A decade of research on alternatives to animal experimentation. Fund. Appl. Toxicol. 24, 29-41.
15. THORNBACK-LECOQ, S., BETTEMS, J.-M., and ZIJLSTRA, J.A. (1997). Correlation between skin irritation and cytotoxicity. In Vitro Toxicol. 10(1),49-53.
16. VAN DE SANDT, J.J.M., RUTTEN, A.A.J.J.L., and KOETER, H.B.W.M. (1993). Cutaneous toxicity testing in organ culture: Neutral red uptake and reduction of tetrazolium salt (MTT). Toxicol. In Vitro 7, 81-86.