Lovastatin inhibits the production of gibberellins but not sterol or carotenoid biosynthesis in Gibberella fujikuroi

Microbiology

Volumn 145, Issue 10, 1999, Pages 2997-3002

  Giordano, Walter ^a   Avalos, Javier ^b   Fernández Martín, Rafael ^b   Cerdá Olmedo, Enrique ^b   Domenech, Carlos E ^a  

^a DEPARTAMENTO DE QUÍMICA   (Argentina)

^b UNIVERSITY OF SEVILLE   (Spain)

Author keywords

Gibberella fujikuroi; Gibberellins; HMG CoA reductase; Lovastatin; Terpenoids

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A; CAROTENOID; GIBBERELLIN; MEVINOLIN; STEROL; TERPENOID;

ARTICLE; FUNGAL GENETICS; GIBBERELLA FUJIKUROI; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SOUTHERN BLOTTING;

GIBBERELLA FUJIKUROI;

EID: 0032863146     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-145-10-2997     Document Type: Article

References (32)

1. Avalos, J. & Cerdá-Olmedo, E. (1987). Carotenoid mutants of Gibberella fujikuroi. Curr Genet 11, 505-511.
2. Avalos, J., Casadesús, J. & Cerdá-Olmedo, E. (1985). Gibberella fujikuroi mutants obtained with UV radiation and N-methyl-N′-nitro-N-nitrosoguanidine. Appl Environ Microbiol 49, 187-191.
3. Basson, M. E., Thorsness, M., Finer-Moore, J., Stroud, R. M. & Rine, J. (1988). Structural and functional conservation between yeast and human 3-hydroxy-3-methylgluraryl coenzyme A reductases, the rate limiting enzyme of sterol biosynthesis. Mol Cell Biol 8, 3797-3808.
4. Bejarano, E. R. & Cerdá-Olmedo, E. (1992). Independence of the carotene and sterol pathways of Phycomyces. FEBS Lett 306, 209-212.
5. Biardi, L. & Krisans, S. K. (1996). Compartmentalization of cholesterol biosynthesis. Conversion of mevalonate to farnesyl diphosphate occurs in the peroxisomes. J Biol Chem 271, 1784-1788.
6. Bradford, M. M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72, 248-254.
7. Candau, R., Avalos, J. & Cerdá-Olmedo, E. (1991). Gibberellins and carotenoids in the wild type and mutants of Gibberella fujikuroi. Appl Environ Microbiol 57, 3378-3382.
8. Candau, R., Avalos, J. & Cerdá-Olmedo, E. (1992). Regulation of gibberellin biosynthesis in Gibberella fujikuroi. Plant Physiol 100, 1184-1188.
9. Chappell, J. (1995a). The biochemistry and molecular biology of isoprenoid metabolism. Plant Physiol 107, 1-6.
10. Chapped, J. (1995b). Biochemistry and molecular biology of the isoprenoid biosynthetic pathway in plants. Annu Rev Plant Physiol Mol Biol 46, 521-547.
11. Coolbaugh, R. C. (1983). Early stages of gibberellin biosynthesis. In The Biochemistry and Physiology of Gibberellins, pp. 53-98. Edited by A. Crozier. New York: Praeger.
12. Corrochano, L. M. & Avalos, J. (1992). Cloning a segment of the gene encoding 3-hydroxy-3-methylglutaryl Coenzyme A reductase in Phycomyces blakesleeanus and Gibberella fujikuroi by the polymerase chain reaction. Exp Mycol 16, 167-171.
13. Domenech, C. E., Giordano, W., Avalos, J. & Cerdá-Olmedo, E. (1996). Separate compartments for the production of sterols, carotenoids, and gibberellins in Gibberella fujikuroi. Eur J Biochem 239, 720-725.
14. Endo, A. & Hasumi, K. (1997). Mevinic acids. In Fungal Biotechnology, pp. 162-172. Edited by T. Anke. Weinheim: Chapman & Hall.
15. Fernández-Martín, R., Reyes, F., Domenech, C. E., Cabrera, E., Bramley, P. M., Barrero, A. F., Avalos, J. & Cerdá-Olmedo, E. (1995). Gibberellin biosynthesis in gib mutants of Gibberella fujikuroi. J Biol Chem 270, 14970-14974.
16. Florin-Christensen, M., Florin-Christensen, J., Garin, C., Isola, E., Brenner, R. R. & Rasmussen, L. (1990). Inhibition of Trypanosoma cruzi growth and sterol biosynthesis by lovastatin. Biochem Biophys Res Commun 166, 1441-1445.
17. Geissman, T. A., Verbiscar, A. J., Phinney, B. O. & Cragg, G. (1966). Studies on the biosynthesis of gibberellins from (-)-kaurenoic acid in cultures of Gibberella fujikuroi. Phytochemistry 5, 933-947.
18. +)-influx in retinoic acid differentiated U937 and HL-60 cells. Cell Signal 6, 735-742.
19. Hampton, R., Dimster-Denk, D. & Rine, J. (1996). The biology of HMG-CoA reductase: the pros of centra-regulation. Trends Biochem Sci 21, 140-145.
20. Lam, W. L. & Doolittle, W. F. (1992). Mevinolin-resistant mutations identify a promoter and the gene for a eukaryote-like 3-hydroxy-3-methylglutaryl-coenzyme A reductase in the archaebacterium Haloferax volcanii. J Biol Chem 267, 5829-5834.
21. Lewer, P. & MacMillan, J. (1983). Effect of compactin on the incorporation of mevalonolactone into gibberellic acid by Gibberella fujikuroi. Phytochemistry 22, 602-603.
22. Mende, K., Homann, V. & Tudzynski, B. (1997). The geranyl-geranyl diphosphate synthase gene of Gibberella fujikuroi: isolation and expression. Mol Gen Genet 255, 96-105.
23. Morehead, T. A., Biermann, B. J., Crowell, D. N. & Randall, S. K. (1995). Changes in protein isoprenylation during the growth of suspension-cultured tobacco cells. Plant Physiol 109, 277-284.
24. Peña-Díaz, J., Montalvetti, A., Camacho, A., Gallego, C., Ruiz-Perez, L. M. & Gonzalez-Pacanowska, D. (1997). A soluble 3-hydroxy-3-methylglutaryl-CoA reductase in the protozoan Trypanosoma cruzi. Biochem J 324, 619-626.
25. Rademacher, W. (1997). Gibberellins. In Fungal Biotechnology, pp. 193-205. Edited by T. Anke. Weinheim: Chapman & Hall.
26. Rohmer, M., Knani, M., Simonin, P., Sutter, B. & Sahm, H. (1993). Isoprenoid biosynthesis in bacteria : a novel pathway for the early steps leading to isopentenyl diphosphate. Biochem J 295, 517-524.
27. Sambrook, J., Fritsch, E. F. & Maniatis, T. (1989). Molecular Cloning: a Laboratory Manual, 2nd edn. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
28. Shapiro, D. J., Nordstrom, J. L., Mitschelen, J. J., Rodwell, V. W. & Schimke, R. T. (1974). Micro assay for 3-hydroxy-3-methylglutaryl-CoA reductase in rat liver and in L-cell fibroblasts. Biochim Biophys Acta 370, 369-377.
29. Sherman, F., Fink, G. R. & Hicks, J. B. (1986). Laboratory Course Manual for Methods in Yeast Genetics. Cold Spring Harbor, NY : Cold Spring Harbor Laboratory.
30. Shiao, M. S. (1983). Inhibition of gibberellin biosynthesis in Gibberella fujikuroi and germination of Oryza sativa by mevinolin. Bot Bull Acad Sin 24, 135-143.
31. Takahashi, N., Phinney, B. O. & MacMillan, J. (1991). Gibberellins. New York: Springer.
32. Woitek, S., Unkles, S. E., Kinghorn, J. R. & Tudzynski, B. (1997). 3-Hydroxy-3-methylglutaryl-CoA reductase gene of Gibberella fujikuroi: isolation and characterization. Curr Genet 31, 38-47.