Antimalarial antisense activity of hexitol nucleic acids

Parasitology Research

Volumn 85, Issue 10, 1999, Pages 864-866

  Flores, Maria Vega C ^a   Atkins, David ^b   Stewart, Thomas Stanley ^a   Van Aerschot, Arthur ^c   Herdewijn, Piet ^c  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b JOHNSON AND JOHNSON   (United States)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ANTISENSE OLIGODEOXYNUCLEOTIDE; RIBOZYME;

ANTIMALARIAL ACTIVITY; ARTICLE; CELL PROLIFERATION; DRUG EFFECT; DRUG EFFICACY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE TARGETING; MALARIA; MEMBRANE TRANSPORT; NONHUMAN; PARASITE SURVIVAL; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0032863109     PISSN: 00443255     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004360050647     Document Type: Article

References (12)

1. Barker RH Jr, Metelev V, Rapaport E, Zamecnik P (1996) Inhibition of Plasmodium falciparum malaria using antisense oligodeoxynucleotides. Proc Natl Acad Sci USA 93: 514-518
2. Barker RH Jr, Metelev V, Coakley, A, Zamecnik P (1998) Plasmodium falciparum: effect of chemical structure on efficacy and specificity of antisense oligonucleotides against malaria in vitro. Exp Parasitol 88: 51-59
3. Butler D (1997) Time to put malaria control on the global agenda. Nature 386: 535-536
4. Bzik DJ, Li W-B, Horii T, Inselburg J (1987) Molecular cloning and sequence analysis of the Plasmodium falciparum dihydrofolate reductase-thymidylate synthase gene. Proc Natl Acad Sci USA 84: 8360-8364
5. Flores MVC, Stewart TS, O'Sullivan WJ (1991) A simple method for the purification of mitochondrial DNA from Plasmodium falciparum. Int J Parasitol 21: 605-608
6. Flores MVC, O'Sullivan WJ, Stewart TS (1994) Characterisation of the carbamoyl phosphate synthetase gene from Plasmodium falciparum. Mol Biochem Parasitol 68: 315-318
7. Flores MVC, Atkins D, Wade D, O'Sullivan WJ, Stewart TS (1997) Inhibition of Plasmodium falciparum proliferation in vitro by ribozymes. J Biol Chem 272: 16940-16945
8. Hendrix C, Rosemeyer H, De Bouvere B, Van Aerschot A, Seela F, Herdewijn P (1997) 1′,5′-Anhydrohexitol oligonucleotides: hybridisation and strand displacement with oligonucleotides, interaction with RNase H and HIV-reverse transcriptase. Chem Eur J 3: 1513-1520
9. Katrib M, Flores MVC, Stewart TS (1997) Targeting pfCPSII mRNA with phosphorothioated antisense deoxyoligonucleotides. Proc 10th Int Congr Protozol, Sydney, Australia, p 114
10. Lambros C, Vanderberg JP (1979) Synchronization of Plasmodium falciparum erythrocytic stages in culture. J Parasitol 65: 418-420
11. Trager W, Jensen JB (1976) Human malaria parasites in continuous culture. Science 193: 673-675
12. Van Aerschot A, Saison-Behmoaras T, Rozenski J, Hendrix C, Schepers G, Verhoeven G, Herdewijn P (1995) Significant antisense effects of anti-Ha ras oligonucleotides conjugated to 3′-polar moieties. Bull Soc Chim Belg 104: 717-720