Sensitization to ethanol's stimulant effect is associated with region-specific increases in brain D2 receptor binding

Psychopharmacology

Volumn 146, Issue 3, 1999, Pages 262-267

  Souza Formigoni, Maria Lucia O ^a   De Lucca, Eliane M ^a   Hipólide, Débora C ^a   Enns, Sylvia C ^a   Oliveira, Maria Gabriela M ^a   Nobrega, José N ^b  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

3H raclopride; Locomotor activity; Mouse

Indexed keywords

ALCOHOL; DOPAMINE 2 RECEPTOR; RACLOPRIDE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; DRUG EFFECT; DRUG SENSITIZATION; LOCOMOTION; MALE; MOUSE; NONHUMAN; NUCLEUS ACCUMBENS; OLFACTORY BULB; PRIORITY JOURNAL; PUTAMEN; RECEPTOR BINDING; SUBSTANTIA NIGRA;

ANIMALS; BRAIN; ETHANOL; MALE; MICE; MOTOR ACTIVITY; RACLOPRIDE; RECEPTORS, DOPAMINE D2;

EID: 0032862368     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130051115     Document Type: Article

References (41)

1. Bardo MT (1998) Neuropharmacological mechanisms of drag reward: beyond dopamine in the nucleus accumbens. Crit Rev Neurobiol 12:37-67
2. Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeeswaran P, Nogami H. Briggs AH, Cohn JB (1990) Allelic association of human dopamine D2 receptor gene in alcoholism. J Am Med Assoc 263:2055-2060
3. Broadbent J, Grahame NJ. Cunningham CL (1995) Haloperidol prevents ethanol-stimulated locomotor activity but fails to block sensitization. Psychopharmacology 120:475-482
4. Clark D, Overton PG (1998) Alterations in excitatory amino-acid-mediated regulation of midbrain dopaminergic neurones induced by chronic psychostimulant administration and stress: relevance to behavioral sensitization and drug addiction. Addict Biol 3:109-135
5. Cohen C, Perrault G, Sanger DJ (1997) Evidence for the involvement of dopamine receptors in ethanol-induced hyperactivity in mice. Neuropharmacology 36:1099-1108
6. Comings D, Muhleman D, Ahn C, Gysin R, Flanagan S (1994) The dopamine D2 receptor gene: a genetic risk factor in substance abuse. Drug Alcohol Depend 34:175-180
7. Cunningham CL, Noble D (1992) Conditioned activation induced by ethanol: role in sensitization and conditioned place preference. Pharmacol Biochem Behav 43:307-313
8. Di Chiara G (1993) Searching for the hidden order in chaos. Commentary on Kalivas et al. "The pharmacology of neural circuitry of sensitization to psychostimulants". Behav Pharmacol 4:335-337
9. Di Chiara G (1997) Alcohol and dopamine. Alcohol Health Res World 21:108-114
10. Di Chiara G, Imperato A (1988) Drugs abused by humans preferentially increase synaptic concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci USA 85:5274-5278
11. Drago J. Padungchaichot P, Accili D, Fuchs S (1998) Dopamine receptors and dopamine transporter in brain function and addictive behaviors: insights from targeted mouse mutants. Dev Neurosci 20:188-203
12. Franklin KBJ, Paxinos G (1997) The mouse brain in stereotaxic coordinates. Academic Press, New York
13. Hietala J, Salonen I, Lappalainen J, Syvalahti E (1990) Ethanol administration does not alter dopamine D1 and D2 receptor characteristics in rat brain. Neurosci Lett 108:289-294
14. Hoffman PL, Tabakoff B (1985) Ethanol's action on brain biochemistry. In: Tarter RE, Van Thiel DH (eds) Alcohol and the brain: chronic effects. Plenum Press, New York, pp 19-68
15. Hruska RE (1988) Effects of ethanol administration on striatal D1 and D2 dopamine receptors. J Neurochem 50:1929-1933
16. Hunt WA, Lands WEM (1992) A role for behavioral sensitization in uncontrolled ethanol intake. Alcohol 9:327-328
17. Kalivas PW, Sorg BA, Hooks MS (1993) The pharmacology and neural circuitry of sensitization to psychostimulants. Behav Pharmacol 4:315-334
18. Lessov CN, Phillips TJ (1998) Duration of sensitization to the locomotor stimulant effects of ethanol in mice. Psychopharmacology 135:374-382
19. Levy AD, Murphy JM, McBride WJ, Lumeng L, Li TK (1991) Microinjection of sulpiride into the nucleus accumbens increases ethanol drinking in alcohol-preferring (P) rats. Alcohol Alcohol Suppl 1:417-420
20. Manley SJ, Little HJ (1997) Enhancement of amphetamine- and cocaine-induced locomotor activity after chronic ethanol administration. J Pharmacol Exp Ther 281:1330-1339
21. Masur J, Boerngen R (1980) The excitatory component of ethanol in mice: a chronic study. Pharmacol Biochem Behav 13:777-780
22. Masur J, Souza MLO, Zwicker AP (1986) The excitatory effect of ethanol: absence in rats, no tolerance and increased sensitivity in mice. Pharmacol Biochem Behav 24:1225-1228
23. Nestby P, Vanderschuren LJMJ, DE Vries TJ, Hogenboom F, Wardeh G, Mulder AH, Schoffelmeer ANM (1997) Ethanol, like psychostimulants and morphine, causes long-lasting hyperreactivity of dopamine and acetylcholine neurons of rat nucleus accumbens: possible role in behavioural sensitization. Psychopharmacology 133:69-76
24. Newlin DB, Thomson JB (1991) Chronic tolerance and sensitization to alcohol in sons of alcoholics. Alcohol Clin Exp Res 15:399-405
25. Noble EP (1996) Alcoholism and the dopaminergic system - a review. Addict Biol 1:333-348
26. Pato C, Macciardi F, Pato MT, Verga M, Kennedy JL (1993) Review of the putative association of dopamine D2 receptor and alcoholism: a meta-analysis. Am J Med Genet 48:78-82
27. Pecins-Thompson M, Peris J (1993) Behavioral and neurochemical changes caused by repeated ethanol and cocaine administration. Psychopharmacology 110:443-450
28. Phillips TJ (1997) Behavior genetics of drug sensitization. Crit Rev Neurobiol 11:21-33
29. Phillips TJ, Shen EH (1996) Neurochemical bases of locomotion and ethanol stimulant effects. Int Rev Neurobiol 39:243-282
30. Phillips TJ, Burkhart-Kasch S, Crabbe JC (1991) Locomotor activity response to chronic ethanol treatment in selectively bred FAST and SLOW mice. Alcohol Alcohol Suppl 1:109-113
31. Phillips TJ, Roberts AJ, Lessov CN (1997) Behavioral sensitization to ethanol: genetics and the effects of stress. Pharmacol Biochem Behav 57:487-493
32. Roberts AJ, Lessov C, Phillips TJ (1995) Critical role for glucocorticoid receptors in stress- and ethanol-induced locomotor sensitization. J Pharmacol Exp Ther 275:790-797
33. Sasaki T, Kennedy JL, Nobrega JN (1997) Localized changes in the GABA-gated chloride channel in rat brain after long-term haloperidol: relation to vacuous chewing movements. Synapse 25:73-79
34. Shen EH, Crabbe JC, Phillips TJ (1995) Dopamine antagonist effects on locomotor activity in naive and ethanol-treated FAST and SLOW selected lines of mice. Psychopharmacology 118:28-36
35. Stefanini E, Fray M, Garau MG, Garau B, Fadda F, Gessa GL (1992) Alcohol-preferring rats have fewer dopamine D2 receptors in the limbic system. Alcohol Alcohol 27:127-130
36. Stewart J, Badiani A (1993) Tolerance and sensitization to the behavioral effects of drugs. Behav Pharmacol 4:289-312
37. Syvalahti EKG, Pohjalainen T, Korpi ER, Palvimaki EP, Ovaska T, Kuoppamaki M, Hietala J (1994) Dopamine D2 receptor gene expression in rat lines selected for differences in voluntary alcohol consumption. Alcohol Clin Exp Res 18:1029-1031
38. Volkow ND, Wang GJ, Fowler JS, Logan J, Hitzemann R, Ding YS, Pappas N, Shea C, Piscani K (1996) Decreases in dopamine receptors but not in dopamine transporters in alcoholics. Alcohol Clin Exp Res 20:1594-1598
39. Weiss F, Lorang MT, Bloom FE, Koob GF (1993) Oral alcohol self-administration stimulates dopamine release in the rat nucleus accumbens: genetic and motivational determinants. J Pharmacol Exp Ther 267:250-258
40. Wise RA, Bozarth MA (1987) A psychomotor stimulant theory of addiction. Psychol Rev 94:469-492
41. Yoshimoto K, Mc Bride W J, Lumeng L, Li TK (1991) Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens. Alcohol 9:17-22