Platelet aggregation and high-intensity transient signals (HITS) in a sheep model of mitral valve replacement

Journal of Heart Valve Disease

Volumn 8, Issue 5, 1999, Pages 476-481

  Raco, Lucia ^a   Belcher, Philip R ^a   Sim, Iain ^a   McGarrity, Anne ^a   Bernacca, Gillian M ^a   Wheatley, David J ^a,b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b GLASGOW ROYAL INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 [(2 DIMETHYLAMINO 2 METHYLPROPYL)THIO] 3 PHENYLQUINOLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOPROSTHESIS; CONTROLLED STUDY; DOPPLER ECHOGRAPHY; MITRAL VALVE PROSTHESIS; MITRAL VALVE REPLACEMENT; NONHUMAN; PRIORITY JOURNAL; SHEEP; THROMBOCYTE AGGREGATION; TRANSTHORACIC ECHOCARDIOGRAPHY;

ANIMALS; BIOPROSTHESIS; ECHOCARDIOGRAPHY; EMBOLISM; HEART VALVE PROSTHESIS IMPLANTATION; MITRAL VALVE; PLATELET AGGREGATION; QUINOLINES; SEROTONIN ANTAGONISTS; SHEEP; ULTRASONOGRAPHY, DOPPLER;

EID: 0032862268     PISSN: 09668519     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Rams JJ, Davis DA, Lolley DM, Berger MP, Spencer MP. Detection of microemboli in patients with artificial heart valves using transcranial Doppler: Preliminary observations. J Heart Valve Dis 1993;2:37-41
2. Grosset DGC, Cowburn P, Georgiadis D, Dargie HJ, Faichney A, Lees KR. Ultrasound detection of cerebral emboli in patients with prosthetic heart valves. J Heart Valve Dis 1994;3:128-132
3. Rundek T, Demarin V, Niederkorn K, Vukovic V. Prevalence of intracranial emboli signals in patients with carotid and cardiac disease. Acta Clin Croat 1995;34:137-143
4. Gaunt ME, Brown L, Hartshorne T, Bell PRF, Naylor AR. Unstable carotid plaques: Preoperative identification and association with intraoperative embolisation detected by transcranial Doppler. Eur J Vasc Endovasc Surg 1996;11:78-82
5. Georgiadis D, Mallinson A, Grosset DG, Lees KR. Coagulation activity and emboli counts in patients with prosthetic cardiac valves. Stroke 1994;25:1211-1214
6. Deklunder G, Lecroart JL, Savoye C, Coquet B, Houdas Y. Transcranial high-intensity Doppler signals in patients with mechanical heart valve prostheses: Their relationship with abnormal intracavitary echoes. J Heart Valve Dis 1996;5:662-667
7. Kaps M, Hansen J, Weiher M, Tiffert K, Kayser I, Droste DW. Clinically silent microemboli in patients with artificial prosthetic aortic valves are predominantly gaseous and not solid. Stroke 1997;28:322-325
8. Chow TW, Hellums JD, Moake JL, Kroll MH. Shear stress-induced von Willebrand factor binding to platelet glycoprotein Ib initiates calcium influx associated with aggregation. Blood 1992;80:113-120
9. Mackay TG, Georgiadis D, Grosset DG, Lees KR, Wheatley DJ. On the origin of cerebrovascular microemboli associated with prosthetic heart valves. Neurol Res 1995;17:349-352
10. Graf TF, Fischer H, Reul H, Rau G. Cavitation potential of mechanical heart valve prostheses. Int J Artif Organs 1991;14:169-174
11. Folts JD, Gallagher K, Rowe GG. Blood flow reductions in stenosed canine coronary arteries: Vasospasm or platelet aggregation? Circulation 1982;65:248-255
12. Ringelstein EB, Droste DW, Babikian VL, et al. Consensus on microembolus detection by TCD. International Consensus Group on Microembolus Detection. Stroke 1998;29:725-729
13. Irwin E, Lang G, Clack R, St. Cyr J, Runge W, Foker J. Long-term evaluation of prosthetic mitral valves in sheep. J Invest Surg 1993;6:133-141
14. Georgiadis D, Mackay TG, Kelman AW, Grosset DG, Wheatley DJ, Lees KR. Differentiation between gaseous and formed embolic materials in vivo. Application in prosthetic heart valve patients. Stroke 1994;25:1559-1563
15. Brown WM, Jay JL, Gott JP, Pan-Chih, Dorsey LM, Churchwell A, Guyton RA. Placement of aortic valve bioprostheses in sheep via a left thoracotomy. Implantation of stentless porcine heterografts. Trans Am Soc Artif Intern Organs 1991;37:M445-M446
16. Schoen FJ, Levy RJ, Hilbert SL, Bianco RW. Antimineralization treatments for bioprosthetic heart valves. Assessment of efficacy and safety. J Thorac Cardiovasc Surg 1992;104:1285-1288
17. Spyt TJ, Fisher J, Reid J, Anderson JD, Wheatley DJ. Animal evaluation of a new pericardial bioprosthetic heart valve. Artif Organs 1988;12:328-336
18. Barnhart GR, Jones M, Ishihara T, Chavez AM, Rose DM, Ferrans VJ. Bioprosthetic valvular failure: Clinical and pathological observations in an experimental animal model. J Thorac Cardiovasc Surg 1982;83:618-631
19. Sands MP, Rittenhouse EA, Mohri H, Merendino KA. An anatomical comparison of human, pig, calf, and sheep aortic valves. Ann Thorac Surg 1969;8:407-414
20. Markus H, Loh A, Brown MM. Detection of circulating cerebral emboli using Doppler ultrasound in a sheep model. J Neurol Sci 1994;122:117-124
21. Droste DW, Hagedorn G, Notzold A, Siemens HJ, Sievers HH, Kaps M. Bi-gated transcranial Doppler for the detection of clinically silent circulating emboli in normal persons and patients with prosthetic cardiac valves. Stroke 1997;28:588-592
22. Georgiadis D, Lindner A, Manz M, Sonntag M, Zunker P, Zerkowski HR, Borggrefe M. Intracranial microembolic signals in 500 patients with potential cardiac or carotid embolic source and in normal controls. Stroke 1997;28:1203-1207
23. Mueller HL, Burckhardt D, Casty M, Pfisterer ME, Buser MW. High intensity transcranial Doppler signals (HITS) after prosthetic valve implantation. J Heart Valve Dis 1994;3:602-606
24. Braun M, Kramann J, Strobach H, Schror K. Incomplete inhibition of platelet secretion by low-dose aspirin. Platelets 1994:325-331
25. Barstad RM, Orvim U, Hamers MJAG, Tjonnford GE, Brosstad FR, Sakariassen KS. Reduced effect of aspirin in thrombus formation at high shear and disturbed laminar flow. Thromb Haemost 1996;75:827-832
26. Gallo I, Frater RWM. Experimental atrioventricular bioprosthetic valve insertion: A simple and successful technique. J Thorac Cardiovasc Surg 1983;31:288-290
27. Belcher PR, Drakeholland AJ, Hynd J, Noble MIM. Dispersion of coronary artery thrombi by antagonism of platelet serotonin receptor in the dog. Cardiovasc Res 1992;26:292-296
28. Belcher PR, Drakeholland AJ, Noble MIM. Antagonism of the platelet 5HT2 receptor in the presence of thrombolysis. Int J Cardiol 1994;43:11-20