In vitro transport and uptake of protohypericin and hypericin in the Caco-2 model

International Journal of Pharmaceutics

Volumn 188, Issue 1, 1999, Pages 81-86

  Kamuhabwa, A R ^a   Augustijns, P ^a   De Witte, P A ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Caco 2; Hypericin; Hypericum; Protohypericin; Transport; Uptake

Indexed keywords

HYPERICIN; PROTOHYPERICIN; UNCLASSIFIED DRUG;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG TRANSPORT; DRUG UPTAKE; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE ABSORPTION; PRIORITY JOURNAL; ULTRAVIOLET SPECTROPHOTOMETRY;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPERICUM; LIGHT; PERYLENE; PLANT EXTRACTS; PLANTS, MEDICINAL; TIME FACTORS;

EID: 0032862028     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(99)00203-3     Document Type: Article

References (17)

1. Butterweck V., Wall A., Liefländer-Wulf U., Winterhoff H., Nahrstedt A. Effects of the total extract and fractions of Hypericum perforatum in animals assays for antidepressant activity. Pharmacopsychiatry. 30(Suppl. 2):1997;117-124.
2. Butterweck V., Petereit F., Winterhoff H., Nahrstedt A. Solubilized hypericin and pseudohypericin from Hypericum perforatum exert antidepressant activity in the forced swimming test. Planta Med. 64:1998;291-294.
3. Chatterjee S.S., Bhattacharya S.K., Wonnemann M., Singer A., Muller W.E. Hyperforin as a possible antidepressant component of Hypericum extracts. Life Sci. 63:1998;499-510.
4. Falk H., Schmitzberger W. On the nature of 'soluble' hypericin in Hypericum species. Monatsschr. Chem. 123:1992;731-739.
5. Falk H., Meyer J., Oberreiter M. A convenient semisynthetic route to hypericin. Monatsschr. Chem. 124:1993;339-341.
6. Kerb R., Brockmöller J., Staffeldt B., Ploch M., Roots I. Single-dose and steady state pharmacokinetics of hypericin and pseudohypericin. Antimicrob. Agents Chemother. 40:1996;2087-2093.
7. Krämer W., Wiartalla R. Bestimmung von Naphthodianthronen (Gesamthypericin) in Johanniskraut (Hypericum perforatum L.). Pharm. Ztg. Wiss. 137:1992;202-207.
8. Lavie G., Mazur Y., Lavie D., Meruelo D. The chemical and biological properties of hypericin. A compound with a broad spectrum of biological activities. Med. Res. Rev. 15:1995;111-119.
9. Linde K., Ramirez G., Mulrow C.D., Pauls A., Weidenhammer W., Melchart D. St John's wort for depression - an overview and meta-analysis of randomised clinical trials. Br. Med. J. 313:1996;253-258.
10. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
11. Nahrstedt A., Butterweck V. Biologically active and other chemical constituents of the herb of Hypericum perforatum L. Pharmacopsychiatry. 30(Suppl. 2):1997;129-134.
12. Raffa R.B. Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals sigma receptor binding. Life Sci. 62:1998;265-270.
13. Sattler S., Schaefer U., Schneider W., Hoelzl J., Lehr C. Binding, uptake, and transport of hypericin by Caco-2 cell monolayers. J. Pharm Sci. 86:1997;1120-1126.
14. Ugwu F., Vandenbogaerde A.L., Merlevede W.J., de Witte P.A. A comparative study on the photocytotoxicity of hypericin on A431 cells using three different assays. Anticancer Res. 18:1998;1181-1184.
15. Vandenbogaerde A.L., Cuveele J.F., Proot P., Himpens B.E., Merlevede W.J., de Witte P.A. Differential cytotoxic effects induced after photosensitization by hypericin. J. Photochem. Photobiol. B. 38:1997;136-142.
16. Vandenbogaerde A.L., Delaey E.M., Vantieghem A.M., Himpens B.E., Merlevede W.J., de Witte P.A. Cytotoxicity and antiproliferative effect of hypericin and derivatives after photosensitization. Photochem. Photobiol. 67:1998;119-125.
17. Wagner H., Bladt S. Pharmaceutical quality of Hypericum extracts. J. Geriatr. Psychiatry Neurol. 7(Suppl. 1):1994;S65-S68.