Construction of an optimal destructive sampling design for noncompartmental AUC estimation

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 27, Issue 2, 1999, Pages 191-212

  Vandenhende, Francois ^a   Comblain, Muriel ^b   Delsemme, Marie Helene ^a   Dewe, Walthere ^a   Hoffman, Wherly P ^c   Boulanger, Bruno ^a  

^a Eli Lilly Benelux   (Belgium)

^b HASSELT UNIVERSITY   (Belgium)

^c ELI LILLY AND COMPANY   (United States)

Author keywords

Mean squared error; Nonlinear mixed model; Nonparametric estimation; Optimal design; Toxicokinetics

Indexed keywords

ALGORITHM; ANALYTICAL ERROR; AREA UNDER THE CURVE; ARTICLE; CALCULATION; MATHEMATICAL ANALYSIS; MODEL; NONLINEAR SYSTEM; PRIORITY JOURNAL; SIMULATION; TOXICOKINETICS;

ALGORITHMS; ANIMALS; AREA UNDER CURVE; HUMANS; LINEAR MODELS; NONLINEAR DYNAMICS; PHARMACOKINETICS; SAMPLING STUDIES; SOFTWARE;

EID: 0032862009     PISSN: 0090466X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1020606006936     Document Type: Article

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