-
2
-
-
0025068791
-
(R)-N-(4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl)nipecotic acid binds with high affinity to the brain GABA uptake carrier
-
Braestrup C, Nielsen EB, Sonnewald U, et al. (R)-N-(4,4-bis(3-methyl-2-thienyl)but-3-en-1-yl)nipecotic acid binds with high affinity to the brain GABA uptake carrier. J Neurochem 1990;54: 639-47.
-
(1990)
J Neurochem
, vol.54
, pp. 639-647
-
-
Braestrup, C.1
Nielsen, E.B.2
Sonnewald, U.3
-
3
-
-
0028105867
-
Anticonvulsant action of tiagabine, a new GABA-uptake inhibitor
-
Giardina WJ. Anticonvulsant action of tiagabine, a new GABA-uptake inhibitor. J Epilepsy 1994;7:161-6.
-
(1994)
J Epilepsy
, vol.7
, pp. 161-166
-
-
Giardina, W.J.1
-
4
-
-
0028999957
-
A review of the preclinical pharmacology of tiagabine: A potent and selective anticonvulsant GABA uptake inhibitor
-
Suzdak PD, Jansen JA. A review of the preclinical pharmacology of tiagabine: a potent and selective anticonvulsant GABA uptake inhibitor. Epilepsia 1995;36:612-26.
-
(1995)
Epilepsia
, vol.36
, pp. 612-626
-
-
Suzdak, P.D.1
Jansen, J.A.2
-
5
-
-
0028149954
-
Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1
-
Borden LA, Dhar TGM, Smith KE, Weinshank RL, Branchek TA, Gluchowski C. Tiagabine, SK&F 89976-A, CI-966, and NNC-711 are selective for the cloned GABA transporter GAT-1. Eur J Pharmacol 1994;269:219-24.
-
(1994)
Eur J Pharmacol
, vol.269
, pp. 219-224
-
-
Borden, L.A.1
Dhar, T.G.M.2
Smith, K.E.3
Weinshank, R.L.4
Branchek, T.A.5
Gluchowski, C.6
-
6
-
-
0029942452
-
Tiagabine pharmacology in profile
-
Brodie MJ. Tiagabine pharmacology in profile. Epilepsia 1995;36 (suppl 6):S7-9.
-
(1995)
Epilepsia
, vol.36
, Issue.6 SUPPL.
-
-
Brodie, M.J.1
-
7
-
-
0030771499
-
Antiepileptic effects of tiagabine, a selective GABA uptake inhibitor, in the rat kindling model of temporal lobe epilepsy
-
Morimoto K, Sato H, Yamamoto Y, Watanabe T, Suwaki H. Antiepileptic effects of tiagabine, a selective GABA uptake inhibitor, in the rat kindling model of temporal lobe epilepsy. Epilepsia 1997;38:966-74.
-
(1997)
Epilepsia
, vol.38
, pp. 966-974
-
-
Morimoto, K.1
Sato, H.2
Yamamoto, Y.3
Watanabe, T.4
Suwaki, H.5
-
8
-
-
0025805321
-
Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor
-
Nielsen EB, Suzdak PD, Andersen KE, Knutsen LJS, Sonnewald U, Braestrup C. Characterization of tiagabine (NO-328), a new potent and selective GABA uptake inhibitor. Eur J Pharmacol 1991;196:257-66.
-
(1991)
Eur J Pharmacol
, vol.196
, pp. 257-266
-
-
Nielsen, E.B.1
Suzdak, P.D.2
Andersen, K.E.3
Knutsen, L.J.S.4
Sonnewald, U.5
Braestrup, C.6
-
9
-
-
0028302236
-
Blockade of GABA uptake with tiagabine inhibits audiogenic seizures and reduces neuronal firing in the inferior colliculus of the genetically epilepsyprone rat
-
Faingold CL, Randall ME, Anderson CA. Blockade of GABA uptake with tiagabine inhibits audiogenic seizures and reduces neuronal firing in the inferior colliculus of the genetically epilepsyprone rat. Exp Neurol 1994;126:225-32.
-
(1994)
Exp Neurol
, vol.126
, pp. 225-232
-
-
Faingold, C.L.1
Randall, M.E.2
Anderson, C.A.3
-
10
-
-
0028597555
-
Lack of tolerance to the anticonvulsant effects of tiagabine following chronic (21 day) treatment
-
Suzdak PD. Lack of tolerance to the anticonvulsant effects of tiagabine following chronic (21 day) treatment. Epilepsy Res 1994; 19:205-13.
-
(1994)
Epilepsy Res
, vol.19
, pp. 205-213
-
-
Suzdak, P.D.1
-
11
-
-
0026279337
-
Tiagabine
-
Pisani F, Perucca E, Avansini G, Richens A, eds. Amsterdam: Elsevier
-
Pierce MW, Suzdak PD, Gustavson LE, et al. Tiagabine. In: Pisani F, Perucca E, Avansini G, Richens A, eds. New antiepileptic drugs. Amsterdam: Elsevier, 1991:157-60.
-
(1991)
New Antiepileptic Drugs
, pp. 157-160
-
-
Pierce, M.W.1
Suzdak, P.D.2
Gustavson, L.E.3
-
12
-
-
0028059486
-
Tiagabine
-
Mengel H. Tiagabine. Epilepsia 1994;35(suppl 5):S81-4.
-
(1994)
Epilepsia
, vol.35
, Issue.5 SUPPL.
-
-
Mengel, H.1
-
14
-
-
0031849905
-
Population analysis of the pharmacokinetics of tiagabine in patients with epilepsy
-
Samara EE, Gustavson LE, El-Shourbagy T, Locke C, Granneman GR, Sommerville KW. Population analysis of the pharmacokinetics of tiagabine in patients with epilepsy. Epilepsia 1998;39:868-73.
-
(1998)
Epilepsia
, vol.39
, pp. 868-873
-
-
Samara, E.E.1
Gustavson, L.E.2
El-Shourbagy, T.3
Locke, C.4
Granneman, G.R.5
Sommerville, K.W.6
-
15
-
-
0030944488
-
Pharmacokinetics and safety of tiagabine in subjects with various degrees of hepatic function
-
Lau AH, Gustavson LE, Sperelakis R, et al. Pharmacokinetics and safety of tiagabine in subjects with various degrees of hepatic function. Epilepsia 1997;38:445-51.
-
(1997)
Epilepsia
, vol.38
, pp. 445-451
-
-
Lau, A.H.1
Gustavson, L.E.2
Sperelakis, R.3
-
16
-
-
0000353470
-
Potential antiepileptic drugs. Tiagabine
-
Levy RH, Mattson RH, Meldrum BS, eds. New York: Raven Press
-
Østergaard LH, Gram L, Dam M. Potential antiepileptic drugs. Tiagabine. In: Levy RH, Mattson RH, Meldrum BS, eds. Antiepileptic drugs. New York: Raven Press, 1995:1057-61.
-
(1995)
Antiepileptic Drugs
, pp. 1057-1061
-
-
Østergaard, L.H.1
Gram, L.2
Dam, M.3
-
17
-
-
0000844484
-
14C tiagabine] after oral administration to human subjects
-
14C tiagabine] after oral administration to human subjects [Abstract]. Epilepsia 1995;36(suppl 2):S158.
-
(1995)
Epilepsia
, vol.36
, Issue.2 SUPPL.
-
-
Bopp, B.1
Gustavson, L.2
Johnson, M.3
-
18
-
-
0031907087
-
Effect of renal impairment on the pharmacokinetics and tolerability of tiagabine
-
Cato A, Gustavson LE, Quian J, El-Shourbagy T, Kelly EA. Effect of renal impairment on the pharmacokinetics and tolerability of tiagabine. Epilepsia 1998;39:43-7.
-
(1998)
Epilepsia
, vol.39
, pp. 43-47
-
-
Cato, A.1
Gustavson, L.E.2
Quian, J.3
El-Shourbagy, T.4
Kelly, E.A.5
-
19
-
-
0030784619
-
The pharmacokinetics of tiagabine in healthy elderly volunteers and elderly patients with epilepsy
-
Snel S, Jansen JA, Mengel HB, Richens A, Larsen S. The pharmacokinetics of tiagabine in healthy elderly volunteers and elderly patients with epilepsy. J Clin Pharmacol 1997;37:1015-20.
-
(1997)
J Clin Pharmacol
, vol.37
, pp. 1015-1020
-
-
Snel, S.1
Jansen, J.A.2
Mengel, H.B.3
Richens, A.4
Larsen, S.5
-
20
-
-
0030960662
-
A single-dose study to define tiagabine pharmacokinetics in pediatric patients with complex partial seizures
-
Gustavson LE, Boellner SW, Granneman GR, et al. A single-dose study to define tiagabine pharmacokinetics in pediatric patients with complex partial seizures. Neurology 1997;48:1032-7.
-
(1997)
Neurology
, vol.48
, pp. 1032-1037
-
-
Gustavson, L.E.1
Boellner, S.W.2
Granneman, G.R.3
-
21
-
-
0029942451
-
Tiagabine monotherapy in the treatment of partial epilepsy
-
Schachter SC. Tiagabine monotherapy in the treatment of partial epilepsy. Epilepsia 1995;36(suppl 6):S2-6.
-
(1995)
Epilepsia
, vol.36
, Issue.6 SUPPL.
-
-
Schachter, S.C.1
-
22
-
-
0028989099
-
Pharmacokinetics of tiagabine, a gamma-aminobutyric acid-uptake inhibitor, in healthy subjects after single and multiple doses
-
Gustavson LE, Mengel HB. Pharmacokinetics of tiagabine, a gamma-aminobutyric acid-uptake inhibitor, in healthy subjects after single and multiple doses. Epilepsia 1995;36:605-11.
-
(1995)
Epilepsia
, vol.36
, pp. 605-611
-
-
Gustavson, L.E.1
Mengel, H.B.2
-
23
-
-
0000259041
-
Lack of clinically important drug interactions between tiagabine and carbamazepine, phenytoin, or valproate
-
Gustavson LE, Cato A, Guenther HJ, et al. Lack of clinically important drug interactions between tiagabine and carbamazepine, phenytoin, or valproate [Abstract]. Epilepsia 1995;36(suppl 3): S159.
-
(1995)
Epilepsia
, vol.36
, Issue.3 SUPPL.
-
-
Gustavson, L.E.1
Cato, A.2
Guenther, H.J.3
-
24
-
-
0031819205
-
Tiagabine, a novel antiepileptic agent: Lack of pharmacokinetic interaction with digoxin
-
Snel S, Jansen JA, Pedersen PC, Jonkman JH, van Heiningen PN. Tiagabine, a novel antiepileptic agent: lack of pharmacokinetic interaction with digoxin. Eur J Clin Pharmacol 1998;54:355-7.
-
(1998)
Eur J Clin Pharmacol
, vol.54
, pp. 355-357
-
-
Snel, S.1
Jansen, J.A.2
Pedersen, P.C.3
Jonkman, J.H.4
Van Heiningen, P.N.5
-
25
-
-
0028092826
-
An evaluation of the interaction between tiagabine and oral contraceptives in female volunteers
-
Mengel HB, Houston A, Back DJ. An evaluation of the interaction between tiagabine and oral contraceptives in female volunteers. J Pharm Med 1994;4:141-50.
-
(1994)
J Pharm Med
, vol.4
, pp. 141-150
-
-
Mengel, H.B.1
Houston, A.2
Back, D.J.3
-
26
-
-
0001646004
-
Tiagabine: Evaluation of the risk of interaction with theophylline, warfarin, digoxin, cimetidine, oral contraceptives, triazolam, or ethanol
-
Mengel H, Jansen JA, Sommerville K, et al. Tiagabine: evaluation of the risk of interaction with theophylline, warfarin, digoxin, cimetidine, oral contraceptives, triazolam, or ethanol [Abstract]. Epilepsia 1995;36(suppl 3):S160.
-
(1995)
Epilepsia
, vol.36
, Issue.3 SUPPL.
-
-
Mengel, H.1
Jansen, J.A.2
Sommerville, K.3
-
27
-
-
0029002710
-
Adjunctive treatment of partial seizures with tiagabine: A placebo-controlled trial
-
Richens A, Chadwick DW, Duncan JS, et al. Adjunctive treatment of partial seizures with tiagabine: a placebo-controlled trial. Epilepsy Res 1995;21:37-42.
-
(1995)
Epilepsy Res
, vol.21
, pp. 37-42
-
-
Richens, A.1
Chadwick, D.W.2
Duncan, J.S.3
-
28
-
-
0001358443
-
Summary of five controlled trials with tiagabine as adjunctive treatment of patients with partial seizures
-
Lassen LC, Sommerville K, Mengel HB, Edwards D, Nielsen B, Shu V. Summary of five controlled trials with tiagabine as adjunctive treatment of patients with partial seizures [Abstract]. Epilepsia 1995;36(suppl 3):S148.
-
(1995)
Epilepsia
, vol.36
, Issue.3 SUPPL.
-
-
Lassen, L.C.1
Sommerville, K.2
Mengel, H.B.3
Edwards, D.4
Nielsen, B.5
Shu, V.6
-
29
-
-
0031886001
-
Tiagabine for complex partial seizures: A randomized, add-on, dose-response trial
-
Uthman BM, Rowan AJ, Ahmann PA, et al. Tiagabine for complex partial seizures: a randomized, add-on, dose-response trial. Arch Neurol 1998;55:56-62.
-
(1998)
Arch Neurol
, vol.55
, pp. 56-62
-
-
Uthman, B.M.1
Rowan, A.J.2
Ahmann, P.A.3
-
30
-
-
0031000352
-
Tiagabine therapy for complex partial seizures
-
Sachdeo RC, Leroy RF, Krauss GL, et al. Tiagabine therapy for complex partial seizures. Arch Neurol 1997;54:595-601.
-
(1997)
Arch Neurol
, vol.54
, pp. 595-601
-
-
Sachdeo, R.C.1
Leroy, R.F.2
Krauss, G.L.3
-
31
-
-
0344878897
-
A double-blind, placebo-controlled trial of tiagabine given three times daily as add-on therapy for refractory partial seizures
-
Northern European Tiagabine Study Group
-
Kalviainen R, Brodie MJ, Duncan J, Chadwick D, Edwards D, Lyby K. A double-blind, placebo-controlled trial of tiagabine given three times daily as add-on therapy for refractory partial seizures. Northern European Tiagabine Study Group. Epilepsy Res 1998;30: 31-40.
-
(1998)
Epilepsy Res
, vol.30
, pp. 31-40
-
-
Kalviainen, R.1
Brodie, M.J.2
Duncan, J.3
Chadwick, D.4
Edwards, D.5
Lyby, K.6
-
32
-
-
0029440080
-
International experience with tiagabine add-on therapy
-
Ben-Menachem E. International experience with tiagabine add-on therapy. Epilepsia 1995;36(suppl 6):S14-21.
-
(1995)
Epilepsia
, vol.36
, Issue.6 SUPPL.
-
-
Ben-Menachem, E.1
-
34
-
-
0004975822
-
Lack of aggravation of epilepsy by tiagabine
-
Somerville E. Lack of aggravation of epilepsy by tiagabine. Epilepsia 1998;39(suppl 6):S142.
-
(1998)
Epilepsia
, vol.39
, Issue.6 SUPPL.
-
-
Somerville, E.1
-
35
-
-
0030946472
-
Cognitive and quality of life effects of differing dosages of tiagabine in epilepsy
-
Dodrill CB, Arnett JL, Sommerville KW, Shu V. Cognitive and quality of life effects of differing dosages of tiagabine in epilepsy. Neurology 1997;48:1025-31.
-
(1997)
Neurology
, vol.48
, pp. 1025-1031
-
-
Dodrill, C.B.1
Arnett, J.L.2
Sommerville, K.W.3
Shu, V.4
-
36
-
-
0000231206
-
Adjunctive tiagabine compared to phenytoin and carbamazepine in the multicenter, double-blind trial of complex partial seizures
-
Biton V. Adjunctive tiagabine compared to phenytoin and carbamazepine in the multicenter, double-blind trial of complex partial seizures. Epilepsia 1998;39(suppl 6):S125-6.
-
(1998)
Epilepsia
, vol.39
, Issue.6 SUPPL.
-
-
Biton, V.1
-
37
-
-
0001434183
-
Long-term use of tiagabine for partial seizures
-
Schachter SC, Deaton R, Sommerville K. Long-term use of tiagabine for partial seizures. Epilepsia 1997;38(suppl 8):S105-6.
-
(1997)
Epilepsia
, vol.38
, Issue.8 SUPPL.
-
-
Schachter, S.C.1
Deaton, R.2
Sommerville, K.3
-
38
-
-
0029980459
-
Tiagabine: The safety landscape
-
Leppik IE. Tiagabine: the safety landscape. Epilepsia 1995;36 (suppl 6):S10-3.
-
(1995)
Epilepsia
, vol.36
, Issue.6 SUPPL.
-
-
Leppik, I.E.1
-
40
-
-
0000532631
-
Absence of visual field defects in patients taking tiagabine
-
Collins SD. Absence of visual field defects in patients taking tiagabine. Epilepsia 1998;39(suppl 6):S146-7.
-
(1998)
Epilepsia
, vol.39
, Issue.6 SUPPL.
-
-
Collins, S.D.1
-
41
-
-
0031747791
-
Nonconvulsive status epilepticus in two patients receiving tiagabine treatment
-
Eckardt KM, Steinhoff BJ. Nonconvulsive status epilepticus in two patients receiving tiagabine treatment. Epilepsia 1998;39:671-4.
-
(1998)
Epilepsia
, vol.39
, pp. 671-674
-
-
Eckardt, K.M.1
Steinhoff, B.J.2
-
42
-
-
0032170041
-
Open-label dosage and tolerability study of tiagabine monotherapy in patients with refractory complex partial seizures
-
Schachter SC, Cahill WT, Wannamaker BB, Shu VS, Sommerville KW. Open-label dosage and tolerability study of tiagabine monotherapy in patients with refractory complex partial seizures. J Epilepsy 1998;11:248-55.
-
(1998)
J Epilepsy
, vol.11
, pp. 248-255
-
-
Schachter, S.C.1
Cahill, W.T.2
Wannamaker, B.B.3
Shu, V.S.4
Sommerville, K.W.5
-
43
-
-
0344720602
-
A monotherapy approach with tiagabine
-
June 30, Dublin
-
Brodie MJ. A monotherapy approach with tiagabine. Presented at 22nd Int Epilepsy Cong Satell Symp, June 30, Dublin, 1997.
-
(1997)
22nd Int Epilepsy Cong Satell Symp
-
-
Brodie, M.J.1
-
44
-
-
0031931720
-
Effects of tiagabine monotherapy on abilities, adjustment, and mood
-
Dodrill CB, Arnett JL, Shu V, Pixton GC, Lenz GT, Sommerville KW. Effects of tiagabine monotherapy on abilities, adjustment, and mood. Epilepsia 1998;39:33-42.
-
(1998)
Epilepsia
, vol.39
, pp. 33-42
-
-
Dodrill, C.B.1
Arnett, J.L.2
Shu, V.3
Pixton, G.C.4
Lenz, G.T.5
Sommerville, K.W.6
-
46
-
-
0000025821
-
Single-blind study of safety, tolerability, and preliminary efficacy of tiagabine as adjunctive treatment of children with epilepsy
-
Uldall P, Bulteau C, Pedersen SA, Dulac O, Meinild H, Lassen LC. Single-blind study of safety, tolerability, and preliminary efficacy of tiagabine as adjunctive treatment of children with epilepsy. Epilepsia 1995;36(suppl 3):S147-8.
-
(1995)
Epilepsia
, vol.36
, Issue.3 SUPPL.
-
-
Uldall, P.1
Bulteau, C.2
Pedersen, S.A.3
Dulac, O.4
Meinild, H.5
Lassen, L.C.6
-
47
-
-
0002301831
-
Pilot study of tiagabine in children with partial seizures
-
Boellner S, McCarty J, Mercante D, Sommerville K. Pilot study of tiagabine in children with partial seizures [Abstract]. Epilepsia 1996;37(suppl 4):S92.
-
(1996)
Epilepsia
, vol.37
, Issue.4 SUPPL.
-
-
Boellner, S.1
McCarty, J.2
Mercante, D.3
Sommerville, K.4
-
48
-
-
0001443391
-
Long-term treatment of partial seizures with tiagabine in children
-
Boellner SW, Deaton R, Sommerville KW. Long-term treatment of partial seizures with tiagabine in children [Abstract]. Epilepsia 1997;38(suppl 8):S208.
-
(1997)
Epilepsia
, vol.38
, Issue.8 SUPPL.
-
-
Boellner, S.W.1
Deaton, R.2
Sommerville, K.W.3
-
49
-
-
0029849590
-
Tiagabine: Current status and potential clinical applications
-
Schachter SC. Tiagabine: current status and potential clinical applications. Exp Opin Invest Drugs 1996;5:1377-87.
-
(1996)
Exp Opin Invest Drugs
, vol.5
, pp. 1377-1387
-
-
Schachter, S.C.1
|