Abnormal expression of tyrosine hydroxylase immunoreactivity in Purkinje cells precedes the onset of ataxia in dilute-lethal mice

Brain Research

Volumn 844, Issue 1-2, 1999, Pages 188-191

  Sawada, Kazuhiko ^a   Komatsu, Suguru ^a   Haga, Hiromi ^a   Oda, Sen Ichi ^b   Fukui, Yoshihiro ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b NAGOYA UNIVERSITY   (Japan)

Author keywords

Ataxia; Cerebellum; Dilute lethal mouse; Purkinje cell; Tyrosine hydroxylase

Indexed keywords

TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; CEREBELLUM; CONTROLLED STUDY; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PURKINJE CELL; SEIZURE;

ANIMALS; ANTIBODIES; BEHAVIOR, ANIMAL; CEREBELLAR ATAXIA; DENDRITES; EPILEPSY; GAIT; GENES, LETHAL; MALE; MICE; MICE, NEUROLOGIC MUTANTS; PURKINJE CELLS; TYROSINE 3-MONOOXYGENASE;

EID: 0032861945     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01899-5     Document Type: Article

References (12)

1. Abbott L.C., Isaacs K.R., Heckroth J.A. Co-localization of tyrosine hydroxylase and Zebrin II immunoreactivities in Purkinje cells of the mutant mice, tottering and tottering/leaner. Neuroscience. 71:1996;461-475.
2. J. Altman, S.A. Bayer, Lobular distribution of precerebellar mossy fibers in the cerebellar cortex, in: J. Altman, S.A. Bayer (Eds.), Development of the Cerebellar System, CRC Press, 1997, pp. 44-53.
3. Austin M.C., Schultzberg M., Abbott L.C., Montpied P., Evers J.R., Paul S.M., Crawley J.N. Expression of tyrosine hydroxylase in cerebellar Purkinje neurons of the mutant tottering and leaner mouse. Mol. Brain Res. 15:1992;227-240.
4. Boegman R.J., Parent A., Hawkes R. Zonation in the rat cerebellar cortex: patches of high acetylcholinesterase activity in the granular layer are congruent with Purkinje cell compartments. Brain Res. 448:1988;237-251.
5. Hess E.J., Wilson M.C. Tottering and leaner mutations perturb transient developmental expression of tyrosine hydroxylase in embryologically distinct Purkinje cells. Neuron. 6:1991;123-132.
6. Kilbourne E.J., Nankova B.B., Lewis E.J., McMahon A., Osaka H., Sabban D.B., Sabban E.L. Regulated expression of the tyrosine hydroxylase gene by membrane depolarization. J. Biol. Chem. 267:1992;7563-7569.
7. 2+ homeostasis. Prog. Neurobiol. 37:1991;255-285.
8. Nankova B., Hiremagalur B., Menezes A., Zeman R., Sabban E. Promoter elements and second messenger pathways involved in transcriptional activation of tyrosine hydroxylase by ionomycin. Mol. Brain Res. 35:1996;164-172.
9. Sawada K., Komatsu S., Haga H., Sun X.-Z., Hisano S., Fukui Y. Abnormal expression of tyrosine hydroxylase immunoreactivity in cerebellar cortex of ataxic mutant mice. Brain Res. 829:1999;107-112.
10. Searle A.G. A lethal allele of dilute in the house mouse. Heredity. 6:1952;395-401.
11. 2+ store in the dendritic spine of Purkinje cells in mice. Neurosci. Lett. 215:1996;169-172.
12. J. Voogd, Cerebellum, in: G. Paxinos (Ed.), The Rat Nervous System, 2nd edn., Academic Press, 1994, pp. 309-350.