Role of CCAA nucleotide repeats in regulation of hemoglobin and hemoglobin-haptaglobin binding protein genes of Haemophilus influenzae

Journal of Bacteriology

Volumn 181, Issue 18, 1999, Pages 5865-5870

  Ren, Zhen ^a   Jin, Hongfan ^a,b   Whitby, Paul W ^a   Morton, Daniel J ^a   Stull, Terrence L ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; HAPTOGLOBIN; HEME; HEMOGLOBIN; NUCLEOTIDE;

ARTICLE; BACTERIAL GENE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE FUSION; HAEMOPHILUS INFLUENZAE TYPE A; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; BACTERIA (MICROORGANISMS); HAEMOPHILUS; HAEMOPHILUS INFLUENZAE; HAEMOPHILUS INFLUENZAE SEROTYPE A; NEGIBACTERIA; PROKARYOTA;

EID: 0032861941     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.181.18.5865-5870.1999     Document Type: Article

References (18)

1. Bachmann, B. J. 1990. Linkage map of Escherichia coli K-12, edition 8. Microbiol. Rev. 54:130-197.
2. Chen, C. J., C. Elkins, and P. F. Sparling. 1998. Phase variation of hemoglobin utilization in Neisseria gonorrhoeae. Infect. Immun. 66:987-993.
3. Fleischmann, R. D., M. D. Adams, O. White, R. A. Clayton, E. F. Kirkness, A. R. Kerlavage, C. J. Bult, J. Tomb, B. A. Dougherty, J. M. Merrick, K. McKenney, G. Sutton, W. FitzHugh, C. Fields, J. D. Gocayne, J. Scott, R. Shirley, L. Liu, A. Glodek, J. M. Kelley, J. F. Weidman, C. A. Phillips, T. Spriggs, E. Hedblom, M. D. Cotton, R. C. Utterback, M. C. Hanna, D. T. Nguyen, D. M. Saudek, R. C. Brandon, L. D. Fine, J. L. Fritchman, J. L. Fuhrmann, N. S. M. Geoghagen, C. L. Gnehm, L. A. McDonald, K. V. Small, C. M. Fraser, H. O. Smith, and J. C. Venter. 1995. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269:496-512.
4. Frangipane, M. E., D. J. Morton, J. A. Wooten, J. M. Pozsgay, and T. L. Stull. 1994. Binding of human hemoglobin by Haemophilus influenzae. FEMS Microbiol. Lett. 118:243-248.
5. High, N. J., M. P. Jennings, and E. R. Moxon. 1996. Tandem repeats of the tetramer 5′-CAAT-3′ present in lic 2A are required for phase variation but not lipopolysaccharide biosynthesis in Haemophilus influenzae. Mol. Microbiol. 20:165-174.
6. Jin, H. 1998. Characterization of an Haemophilus influenzae gene, hgpA, encoding a hemoglobin and hemoglobin-haptoglobin binding protein. Ph.D. thesis. University of Oklahoma, Oklahoma City.
7. Jin, H., Z. Ren, J. M. Pozsgay, C. Elkins, P. W. Whitby, D. J. Morton, and T. L. Stull. 1996. Cloning of a DNA fragment encoding a heme-repressible hemoglobin-binding outer membrane protein from Haemophilus influenzae. Infect. Immun. 64:3134-3141.
8. Jin, H., Z. Ren, P. W. Whitby, D. J. Morton, and T. L. Stull. 1999. Characterization of hgpA, a gene encoding a hemoglobin/hemoglobin-haptoglobin binding protein of Haemophilus influenzae. Microbiology 145:905-914.
9. Kimura, A., and E. J, Hansen. 1986. Antigenic and phenotypic variations of Haemophilus influenzae type b lipopolysaccharide and their relationship to virulence. Infect. Immun. 51:69-79.
10. Minton, N. P. 1984. Improved plasmid vectors for the isolation of translational lac gene fusions. Gene 31:269-273.
11. Morton, D. J., P. W. Whitby, H. Jin, Z. Ren, and T. L. Stull. 1999. Effect of multiple mutations in the hemoglobin-and hemoglobin-haptoglobin-binding proteins, HgpA, HgpB, and HgpC of Haemophilus influenzae type b. Infect. Immun. 67:2729-2739.
12. Moxon, E. R., P. B. Rainey, M. A. Nowak, and R. E. Lenski. 1994. Adaptive evolution of highly mutable loci in pathogenic bacteria. Curr. Biol. 4:24-33.
13. Ren, Z., H. Jin, D. J. Morton, and T. L. Stull. 1998. hgpB, a gene encoding a second Haemophilus influenzae hemoglobin-and hemoglobin-haptoglobin-binding protein. Infect. Immun. 66:4733-4741.
14. Spenser, H. T., and R. M. Herriott. 1965. Development of competence in Haemophilus influenzae. J. Bacteriol. 90:911-920.
15. Szabo, M., D. Maskell, P. Butler, J. Love, and R. Moxon. 1992. Use of chromosomal gene fusions to investigate the role of repetitive DNA in regulation of genes involved in lipopolysaccharide biosynthesis in Haemophilus influenzae. J. Bacteriol. 174:7245-7252.
16. R resistance. Nucleic Acids Res. 16:3587.
17. van Belkum, A., S. Scherer, L. van Alphen, and H. Verbrugh. 1998. Short-sequence DNA repeats in prokaryotic genomes. Microbiol. Mol. Biol. Rev. 62:275-293.
18. Weiser, J. N., J. M. Love, and E. R. Moxon. 1989. The molecular mechanism of phase variation of H. influenzae lipopolysaccharide. Cell 59:657-665.