Diabetes insipidus and increased serum levels of leptin and lactate-dehydrogenase (LDH) in an adolescent boy with a primary intracranial germinoma. Case Report and an endocrinological revaluation of literature

Journal of Endocrinological Investigation

Volumn 22, Issue 7, 1999, Pages 558-561

  Carella, Carlo ^a,b   Rotondi, M ^a   Del Buono, A ^a   Sinisi, A M ^a   Del Basso De Caro, M L ^a   Mone, C M ^a   Vizioli, L ^a   Sorvillo, F ^a   Mazziotti, G ^a   Bellastella, A ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b University Federico II ^*  (Italy)

Author keywords

Cerebral tumor; Chorionic gonadotropin; Intracranial germinoma; Lactate dehydrogenase; Leptin

Indexed keywords

BROMOCRIPTINE; CHORIONIC GONADOTROPIN; LACTATE DEHYDROGENASE; LEPTIN; OCTREOTIDE; PROLACTIN;

ADOLESCENT; ARTICLE; BLOOD LEVEL; CASE REPORT; CLINICAL FEATURE; DIABETES INSIPIDUS; DIAGNOSTIC IMAGING; DIFFERENTIAL DIAGNOSIS; DIPLOPIA; GERM CELL TUMOR; GONADOTROPIN BLOOD LEVEL; HUMAN; IMMUNOHISTOCHEMISTRY; INTRACRANIAL TUMOR; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; OPTIC NERVE GLIOMA; POLYDIPSIA; POLYURIA; PROLACTIN BLOOD LEVEL; TUMOR BIOPSY;

EID: 0032861697     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03343609     Document Type: Article

References (24)

1. Moskwitz MA, Wurtman R.J. Pathological states involving the pineal. In: Martini L., Besser G.M. (Eds.), Clinical neuroendocrinology. Academic, New York, 1977, p. 503.
2. De Girolami U. Pathology of tumors of the pineal region. In: Schmidek H.H. (Ed.), Pineal tumors. Masson, New York, 1977, p. 1.
3. Horowitz M.B., Hall W.A. Central nervous system germinomas. A Review. Arch. Neurol. 1991, 48: 652-657.
4. Imura H., Kato Y., Nakai Y. Endocrine aspects of tumors arising from suprasellar, third ventricular regions. Prog. Exp. Tumor Res. 1987, 30: 313-324.
5. Sklar C.A., Grumbach M.M., Kaplan S.L., Conte F.A. Hormonal and metabolic abnormalities associated with central nervous system germinoma in children and adolescents and the effect of therapy: Report of 10 patients. J. Clin. Endocrinol. Metab. 1981, 52: 9-16.
6. Buchfelder M., Fahlbusch R., Walther M., Mann K. Endocrine disturbances in suprasellar germinomas. Acta Endocrinol. (Copenh.) 1989, 120: 337-342.
7. Cohen D.N., Steinberg M., Buchwald R. Suprasellar germinomas: diagnostic confusion with optic gliomas. Case Report. J. Neurosurg. 1974, 41: 490-493.
8. Mootha S.L., Barkovich A.J., Grumbach M.M., Edwards M.S., Gitelman S.E., Kaplan S.L., Conte F.A. Idiopathic hypothalamic diabetes insipidus, pituitary stalk thickening, and the occult intracranial germinoma in children and adolescents. J. Clin. Endocrinol. Metab. 1997, 82: 1362-1367.
9. Chico A., Puig-Domingo M., Martul P., De Juan M, Prats J.M., Mauricio D., Webb S.M. Reversible endocrine dysfunction and pituitary stalk enlargement. J. Endocrinol. Invest. 1998, 21: 122-127.
10. Ahmed S.R., Shalet S.M., Price D.A., Pearson D. Human chorionic gonadotrophin secreting pineal germinoma and precocious puberty. Arch. Dis. Child. 1984, 58: 743-745.
11. Hewlett T.A., El-Senoussi M., Fox J.L., Woodhouse N.J.Y. Puberty due to a mixed germ cell tumor of the hypothalamus secreting BhCG and Alpha-Fetoprotein. Horm. Res. 1987, 25: 13-17.
12. Rivarola M.A., Mendilaharzu H., Warman M., Belgorosky A., Iorcansky S., Castellano M., Caresana A., Chaler E., Maceiras M. Endocrine disorders in 66 suprasellar and pineal tumors of patients with prepubertal and pubertal ages. Horm. Res. 1992, 37: 1-6.
13. Kubo O., Yamasaki N., Kamijo Y., Amano K., Kitamura K., Demura R. Human chorionic gonadotropin produced by ectopic pinealoma in a girl with precocious puberty. Case Report. J. Neurosurg. 1977, 47: 101-105.
14. Romshe C.A., Sotos J.F. Intracranial human chorionic gonadotropin-secreting tumor with precocious puberty. J. Pediatr. 1975, 2: 250-252.
15. Pomarede R., Czemichow P., Finidori J., Pfister A., Roger M., Kalifa C., Zucker J.M., Pierre-Kahn A., Rappaport R. Endocrine aspects and tumoral markers in intracranial germinoma: An attempt to delineate the diagnostic procedure in 14 patients. J. Pediatr. 1982, 101: 374-378.
16. Wass J.A.H., Jones A.E., Rees L.H., Besser G.M. hCGβ producing pineal choriocarcinoma. Clin. Endocrinol. (Oxf.) 1982, 17: 423-431.
17. Cho D.Y., Wang Y.C., Ho W.L. Primary intrasellar mixed germ-cell tumor with precocious puberty and diabetes insipidus. Child's Nerv. Syst. 1997, 13: 42-46.
18. Costagliola S., Niccoli P., Florentino M., Carayon P. European collaborative study of luteinizing hormone assay: 1. Epitope specificity of luteinizing hormone monoclonal antibodies and surface mapping of pituitary and urinary luteinizing hormone. J. Endocrinol. Invest. 1994, 17: 397-406.
19. Costagliola S., Niccoli P., Florentino M., Carayon P. European collaborative study of luteinizing hormone assay: 2. Discrepancy among assay kits is related to variation both in standard curve calibration and epitope specificity of kit monoclonal antibodies. J. Endocrinol. Invest. 1994, 17: 407-416.
20. Niccoli P., Costagliola S., Patricot M.C., Mallet B., Benahmed M., Carayon P. European collaborative study of LH assay: 3. relationship of immunological reactivity, biological activity and charge of human luteinizing hormone. J. Endocrinol. Invest. 1994, 19: 260-267.
21. Pomarede R., Finidori J., Czernichow P., Pfister A., Hirsch J.F., Rappaport R. Germinoma in a boy with precocious puberty: Evidence of hCG secretion by the tumoral cells. Child's Brain 1984, 11: 298-303.
22. Sklar C.A., Conte F.A., Kaplan S.L., Grumbach M.M. Human chorionic gonadotropin-secreting pineal tumor: relation to pathogenesis and sex limitation of sexual precocity. J. Clin. Endocrinol. Metab. 1981, 53: 656-660.
23. Roth C., Wilken B., Hanefeld F., Schroter W., Leonhardt U. Hyperphagia in children with craniopharyngioma is associated with hyper leptinaemia and a failure in the downregulation of appetite. Eur. J. Endocrinol. 1998, 138: 89-91.
24. Chisholm J.C., Darmady J.M., Kohler J.A. Dysgerminoma in mother and daughter: use of lactate dehydrogenase as a tumor marker in the child. Pediatr. Hematol. Oncol. 1995, 12: 305-308.