Acute effects of venlafaxine and paroxetine on serotonergic transmission in human volunteers

Psychopharmacology

Volumn 146, Issue 2, 1999, Pages 194-198

  Porter, Richard J ^a   McAllister Williams, R Hamish ^a   Young, Allan H ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Growth hormone; Human volunteer; L Tryptophan; Paroxetine; Prolactin; Receptor; Serotonin; Venlafaxine

Indexed keywords

ANTIDEPRESSANT AGENT; GROWTH HORMONE; NORADRENALIN UPTAKE INHIBITOR; PAROXETINE; PINDOLOL; PLACEBO; PROLACTIN; SEROTONIN; SEROTONIN 1A ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; TRYPTOPHAN; VENLAFAXINE;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG INDUCED DISEASE; GROWTH HORMONE RELEASE; HUMAN; MALE; MENTAL DISEASE; NAUSEA; NEUROTRANSMISSION; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROLACTIN RELEASE; RANDOMIZED CONTROLLED TRIAL; SEROTONINERGIC SYSTEM; VOMITING;

ADOLESCENT; ADULT; AREA UNDER CURVE; CLOMIPRAMINE; CYCLOHEXANOLS; HUMAN GROWTH HORMONE; HUMANS; MALE; NAUSEA; PAROXETINE; PROLACTIN; SEROTONIN; SEROTONIN UPTAKE INHIBITORS; SYNAPTIC TRANSMISSION; TRYPTOPHAN; VOMITING;

EID: 0032861540     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130051106     Document Type: Article

References (36)

1. Aellig WH (1976) β-Adrenoceptor blocking activity and duration of action of pindolol and propranolol in healthy volunteers. Br J Clin Pharmacol 3:251-257
2. Anderson IM, Cowen PJ (1986) Clomipramine enhances prolactin and growth hormone responses to L-tryptophan. Psychopharmacology 89:131-133
3. Artigas F (1993) 5-HT and antidepressants: new views from microdialysis studies. Trends Pharmacol Sci 14:262
4. Beique JC, de Montigny C, Blier P, Debonnel G (1996) Blockade of 5-HT and NE reuptake by venlafaxine: in vivo electrophysiological studies in the rat. Soc Neurosci Abstr 22:180
5. Beique JC, Lavoie N, de Montigny C, Debonnel G (1998) Affinities of venlafaxine and various reuptake inhibitors for the serotonin and norepinephrine transporters. Eur J Pharmacol 349: 129-132
6. Blier P, de Montigny C (1994) Current advances and trends in the treatment of depression. Trends Pharmacol Sci 15:220-226
7. Bolden-Watson C, Richelson E (1993) Blockade by newly-developed antidepressants of biogenic amine uptake into rat brain synaptosomes. Life Sci 52:1023-1029
8. Carlsson A, Corrodi H, Fuxe K, Hökfelt T (1969a) Effects of some antidepressant drugs on depletion of intraneuronal brain catecholamine stores caused by 4-alpha-dimethyl-metatyramine. Eur J Pharmacol 15:367-373
9. Carlsson A, Corrodi H, Fuxe K, Hökfelt T (1969b) Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-alpha-dimethyl-metatyramine. Eur J Pharmacol 5:357-366
10. Chaput Y, Blier P, de Montigny C (1986) In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals. J Neurosci 6:2796-2801
11. Checkley SA (1980) Neuroendocrine tests of monoamine function in man: a review of basic theory and its application to the study of depressive illness. Psychol Med 10:35-53
12. Debonnel G, Blier P, Saint-Andre E, Hebert C, de Montigny C (1998) Comparison of the effects of low and high doses of venlafaxine on serotonin and norepinephrine reuptake processes in patients with major depression and healthy volunteers. 21st CINP Congress, Glasgow, SM1004
13. Fuller RW (1994) Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis. Life Sci 55:163-167
14. Gallager DW, Aghajanian GK (1976) Inhibition of firing of raphe neurones by tryptophan and 5-hydroxytryptophan: blockade by inhibiting serotonin synthesis with Ro-4-4602. Neuropharmacology 15:149-156
15. Gartside SE, Cowen PJ, Sharp T (1992) Effect of 5-hydroxy-L-tryptophan on the release of 5-HT in rat hypothalamus in vivo as measured by microdialysis. Neuropharmacology 31:9-14
16. 1A autoreceptors and noradrenergic mechanisms. Psychopharmacology 130:261-268
17. Hajós M, Gartside SE, Sharp T (1995) Inhibition of median and dorsal raphé neurones following administration of the selective serotonin reuptake inhibitor paroxetine. Naunyn-Schmiedeberg's Arch Pharmacol 351:624-629
18. Hall H, Ogren S (1981) Effects of antidepressant drugs on different receptors in the brain. Eur J Pharmacol 70:393-407
19. Holliday SM, Plosker GL (1993) Paroxetine: a review of its pharmacology, therapeutic use in depression and therapeutic potential in diabetic neuropathy. Drugs Aging 3:278-299
20. 1 recognition sites. J Recept Res 8:59-81
21. Jones RL, Luscombe DK (1976) Plasma levels of clomipramine and its N-desmethyl metabolite following oral clomipramine in man. Br J Pharmacol 57:430
22. Koenig JI, Gudelsky GA, Meltzer HY (1987) Stimulation of corticosterone and beta-endorphin secretion in the rat by selective 5-HT receptor subtype activation. Eur J Pharmacol 137:1-8
23. Marshall EF, Kennedy WN, Eccleston D (1987) Whole blood serotonin and plasma tryptophan using high-pressure liquid chromatography with electrochemical detection. Biochem Med Metab Biol 37:81-86
24. McCance SL, Cowen PJ, Waller H, Grahame-Smith DG (1987) The effects of metergoline on endocrine responses to L-tryptophan. J Psychopharmacol 2:90-94
25. Montgomery SA (1995) Rapid onset of action of venlafaxine. Int Clin Psychopharmacol 10:21-27
26. Morton W, Sonne S, Verga M (1995) Venlafaxine: a structurally unique and novel antidepressant. Ann Pharmacother 29:387-395
27. Moyer JA, Andree TH, Haskins JT, Husbands G, Muth EA (1992) The preclinical pharmacological profile of venlafaxine: a novel antidepressant agent. Clin Neuropharmacol 15:435B
28. Muth E, Moyer J, Haskins J, Andree T, Husbands G (1991) Biochemical, neurophysiological and behavioural effects of Wy-45233 and other identified metabolites of the antidepressant venlafaxine. Drug Dev Res 23:191-199
29. Nalepa I, Manier DH, Gillespie DD, Rossby SP, Schmidt DE, Sulser F (1998) Lack of beta adrenoceptor desensitisation in brain following the dual noradrenalin and serotonin reuptake inhibitor venlafaxine. Eur Neuropsychopharmacol 8:227-232
30. Power AC, Cowen PJ (1992) Neuroendocrine challenge tests: assessment of 5-HT function in anxiety and depression. Mol Aspects Med 13:205-220
31. Price LH, Charney DS, Delgado PL, Goodman WK, Krystal JH, Woods SW, Heninger GR (1990) Clinical studies of 5-HT function using IV L-tryptophan. Prog Neuro-Psychopharmacol Biol Psychiatry 14:459-472
32. Smith CE, Ware CJ, Cowen PJ (1991) Pindolol decreases prolactin and growth hormone responses to intravenous L-tryptophan. Psychopharmacology 103:140-142
33. Upadhyaya AK, Deakin JF, Pennell I (1990) Hormonal response to L-tryptophan infusion: effect of propranolol. Psychoneuroendocrinology 15:309-312
34. Upadhyaya AK, Pennell I, Cowen PJ, Deakin JF (1991) Blunted growth hormone and prolactin responses to L-tryptophan in depression; a state-dependent abnormality. J Affect Disord 21:213-218
35. van Praag HM, Lemus C, Kahn R (1987) Hormonal probes of central serotonergic activity: do they really exist? Biol Psychiatry 22:86-98
36. Wurtman RJ (1982) Nutrients that modify brain function. Sci Am 246:50-59