Dynamic hyperinflation and flow limitation during methacholine-induced bronchoconstriction in asthma

European Respiratory Journal

Volumn 14, Issue 2, 1999, Pages no-

  Tantucci, C ^a,d   Ellaffi, M ^b   Duguet, A ^b   Zelter, M ^b   Similowski, T ^b   Derenne, J P ^b   Milic Emili, J ^c  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b SORBONNE UNIVERSITÉ   (France)

^c MCGILL UNIVERSITY   (Canada)

^d Ospedale Regionale Torrette   (Italy)

Author keywords

Asthma; Dynamic hyperinflation; Dyspnoea; Flow limitation; Negative expiratory pressure

Indexed keywords

METHACHOLINE;

ADULT; ARTICLE; ASTHMA; BRONCHOSPASM; CLINICAL ARTICLE; CONTROLLED STUDY; DYSPNEA; FEMALE; FORCED EXPIRATORY VOLUME; HUMAN; LUNG FUNCTION TEST; MALE; PRIORITY JOURNAL; PROVOCATION TEST;

EID: 0032861367     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/9031936.99.14224599     Document Type: Article

References (24)

1. Woolcock AJ, Rebuck AS, Cade JF, Read J. Lung volume changes in asthma measured concurrently by two methods. Am Rev Respir Dis 1971; 104: 703-709.
2. Martin JG. Respiratory mechanics in asthma. Eur Respir Rev 1993; 3: 14, 444-447.
3. Martin JG, Powell E, Shore S, Emrich J, Engel LA. The role of respiratory muscles in the hyperinflation of bronchial asthma. Am Rev Respir Dis 1980; 121: 443-447.
4. Muller N, Bryan AC, Zamel N. Tonic inspiratory muscle activity as a cause of hyperinflation in histamine-induced asthma. J Appl Physiol 1980; 49: 869-874.
5. Collett PW, Brancatisano T, Engel LA. Changes in glottic aperture during bronchial asthma. Am Rev Respir Dis 1983; 128: 719-723.
6. Cormier Y, Lecours R, Legris C. Mechanisms of hyperinflation in asthma. Eur Respir J 1990; 3: 619-624.
7. Pellegrino R, Violante B, Nava S, Rampulla C, Brusasco V, Rodarte JR. Expiratory airflow limitation and hyperinflation during methacholine-induced bronchoconstriction. J Appl Physiol 1993; 75(4): 1720-1727.
8. Koulouris NG, Valta P, Lavoie A, et al. A simple method to detect expiratory flow limitation during spontaneous breathing. Eur Respir J 1995; 8: 306-313.
9. Sterk PJ, Fabbri LM, Quanjer PhH, et al. Airway responsiveness: standardized challenge testing with pharmacological, physical and sensitizing stimuli in adults. Eur Respir J 1993; 6 (Suppl. 16): 53-83.
10. Borg GAV, Psychophysical basis of perceived exertion. Med Sci Sports Exerc 1982; 14: 377-381.
11. Melissinos CG, Mead J. Maximum expiratory flow changes induced by longitudinal tension on the trachea in normal subjects. J Appl Physiol 1977; 43: 537-544.
12. Gardner RM, Hankinson JL, Clausen JL, Crapo RO, Johnson RO Jr, Epler GR. American Thoracic Society standardization of spirometry - 1987 update. Am Rev Respir Dis 1987; 13 6: 1285-1298.
13. Lougheed MD, Lam M, Forkert L, Webb KA, O'Donnell DE. Breathlessness during acute bronchoconstriction in asthma: pathophysiologic mechanism. Am Rev Respir Dis 1993; 148: 1452-1459.
14. Quanjer PhH, Tammeling GJ, Cotes JE et al. Lung volumes and forced ventilatory flows: report of the Working Party 'standardization of lung function tests', European Community for Coal and Steel. Eur Respir J 1993; 6 (Suppl 16): 5-40.
15. Tantucci C, Mehiri S, Duguet A, et al. Application of negative expiratory pressure during expiration and activity of genioglossus in humans. J Appl Physiol 1998; 84(3): 1076-1082.
16. Wheatley JR, West S, Cala SJ, Engel LA. The effect of hyperinflation on respiratory muscle work in acute induced asthma. Am Rev Respir Dis 1990; 3: 625-632.
17. Fish JE, Ankin MG, Kelly JF, Peterman VL. Regulation of bronchomotor tone by lung inflation in asthmatic and non-asthmatic subjects. J Appl Physiol 1981; 50: 1079-1086.
18. Parham WM, Shepard RH, Norman PS, Fish JE. Analysis of time course and magnitude of lung inflation effects on airway tone: relation to airway reactivity. Am Rev Respir Dis 1983; 128: 240-245.
19. D'Angelo E, Prandi E, Marazzini L, Milic-Emili J. Dependence of maximal flow-volume curves on time-course of preceding inspiration in patients with chronic obstructive lung disease. Am Rev Respir Dis 1994; 150: 1581-1586.
20. Boczkowski J, Murciano D, Pichot M-H, Ferretti A, Pariente R, Milic-Emili J. Expiratory flow limitation in stable asthmatic patients during resting breathing. Am J Respir Crit Care Med 1997; 156: 752-757.
21. Lougheed MD, Webb KA, O'Donnell DE. Breathlessness during induced lung hyperinflation in asthma: The role of the inspiratory threshold load. Am J Respir Crit Care Med 1995; 152: 911-920.
22. Tuxen DV. Detrimental effects of positive end-expiratory pressure during controlled mechanical ventilation in patients with severe airflow obstruction. Am Rev Respir Dis 1989; 140: 5-9.
23. Martin JG, Shore S, Engel LA. Effect of continuous positive airway pressure on respiratory mechanics and pattern of breathing in induced asthma. Am Rev Respir Dis 1982; 126: 812-817.
24. Bellofiore S, Ricciardolo FLM, Ciancio N, et al. Changes in respiratory drive account for the magnitude of dyspnoea during bronchoconstriction in asthmatics. Eur Respir J 1996; 9: 1155-1159.