Human aqueous and vitreous humour levels of ciprofloxacin following oral and topical administration

Eye

Volumn 13, Issue 4, 1999, Pages 555-558

  Çekiç, Osman ^a,c   Batman, Coşar ^a   Yaşar, Ümit ^b   Başci, Nursabah E ^b   Bozkurt, Atilla ^b   Kayaalp, S Oguz ^b  

^a SSK Eye Hosptial   (Turkey)

^b HACETTEPE UNIVERSITY   (Turkey)

^c NONE   (Turkey)

Author keywords

Aqueous; Ciprofloxacin; High performance liquid chromatography; Oral; Topical; Vitreous

Indexed keywords

CIPROFLOXACIN;

ADULT; AQUEOUS HUMOR; ARTICLE; CILIARY DISK; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; MALE; ORAL DRUG ADMINISTRATION; TOPICAL DRUG ADMINISTRATION; VITRECTOMY; VITREOUS BODY;

EID: 0032860490     PISSN: 0950222X     EISSN: None     Source Type: Journal    
DOI: 10.1038/eye.1999.137     Document Type: Article

References (21)

1. Neu HC. Microbiologic aspects of fluoroquinolones. Am J Ophthalmol 1991;112(Suppl):S15-24.
2. Leibowitz HM. Clinical evaluation of ciprofloxacin 0.3% ophthalmic solution for treatment of bacterial keratitis. Am J Ophthalmol 1991;112(Suppl):S34-47.
3. Cokington CD, Hyndiuk RA. Insights from experimental data on ciprofloxacin in the treatment of bacterial keratitis and ocular infections. Am J Ophthalmol 1991;112(Suppl):S25-8.
4. Lesk MR, Ammann H, Marcil G, Vinet B, Lamer L, Sebag M. The penetration of oral ciprofloxacin into the aqueous humor, vitreous, and subretinal fluid of humans. Am J Ophthalmol 1993;115:623-8.
5. Alfaro DV, Hudson SJ, Rafanan MM, Moss ST, Levy SD. The effect of trauma on the ocular penetration of intravenous ciprofloxacin. Am J Ophthalmol 1996;122:678-83.
6. Hooper DC, Wolfson JS, Ng EY, Swartz MN. Mechanisms of action of and resistance to ciprofloxacin. Am J Med 1987;82(Suppl 4A):12-9.
7. Crump B, Wise R, Dent J. Pharmacokinetics and tissue penetration of ciprofloxacin. Antimicrob Agents Chemother 1983;24:784-6.
8. Hoffken G, Lode H, Prinzing C, Borner K, Koeppe P. Pharmacokinetics of ciprofloxacin after oral and parenteral administration. Antimicrob Agents Chemother 1985;27:375-9.
9. Arcieri G, Griffith E, Gruenwaldt G, Heyd A, O'Brian B, Becker N, August R. Ciprofloxacin: an update on clinical experience. Am J Med 1987;82(Suppl 4A):381-6.
10. Basci NE, Bozkurt A, Kalayci D, Kayaalp SO. Rapid liquid chromatographic assay of ciprofloxacin in human aqueous humor. J Pharm Biomed Anal 1996;14:353-6.
11. Cutarelli PE, Lass JH, Lazarus HM, Putmanet SC, Jacobs MR. Topical fluoroquinolones: antimicrobial activity and in vitro corneal epithelial toxicity. Curr Eye Res 1991;10:557-63.
12. Guzek JP, Chacko D, Kettering JD, Wessels IF, Aprecio RM. Comparison of topical ciprofloxacin to conventional antibiotic therapy in the treatment of experimental Pseudomonas aeruginosa keratitis. Cornea 1994;13:500-4.
13. Donnenfeld ED, Schlier A, Perry HD, Aulicino T, Gombert ME, Syder R. Penetration of topically applied ciprofloxacin, norfloxacin and ofloxacin into aqueous humor. Ophthalmology 1994;101:902-5.
14. Akkan AG, Mutlu I, Ozyazgan S, Gok A, Yigit U, Ozuner Z, Senses V, Pekel H. Penetration of topically applied ciprofloxacin, norfloxacin and ofloxacin into the aqueous humor of the uninflamed eye. J Chemother 1997;9:257-62.
15. Durmaz B, Marol S, Durmaz R, Oram O, Hepsen IF, Bozkurt A. Aqueous humor penetration of topically applied ciprofloxacin, ofloxacin and tobramycin. Arzneimittelforschung 1997;47:413-5.
16. Çekiç O, Batman C, Totan Y, Yasar Ü, Basci NE, Bozkurt A, Kayaalp SO. Penetration of ofloxacin and ciprofloxacin in aquaeous humor after topical administration. Ophthalmic Surg Lasers 1999;30:465-8.
17. Sweeney G, Fern AI, Lindsay G, Doig MW. Penetration of ciprofloxacin into the aqueous humour of the uninflamed human eye after oral administration. J Antimicrob Chemother 1990;26:99-105.
18. El Baba FZ, Trousdale MD Gauderman WJ, Wagner DG, Liggett PE. Intravitreal penetration of oral ciprofloxacin in humans. Ophthalmology 1992;99:483-6.
19. Keren G, Alhalel A, Bartov E, Cohen RK, Rubinstein E, Segev S, et al. The intravitreal penetration of orally administered ciprofloxacin in humans. Invest Ophthalmol Vis Sci 1991;32:2388-92.
20. Madu AA, Mayers M, Perkins R, Liu W, Drusano GL, Aswani R, et al. Aqueous and vitreous penetration of ciprofloxacin following different modes of systemic administration. Exp Eye Res 1996;63:129-36.
21. Çekiç O, Batman C, Yasar Ü, Basci NE, Bozkurt A, Kayaalp SO. Comparison of aqueous humour and vitreous humour levels of two 0.3% ciprofloxacin eyedrops. Can J Ophthalmol 1998;33:373-6.