Daily mirfentanil induces (cross-) tolerance to the rate-decreasing effects of morphine and not mirfentanil

Behavioural Pharmacology

Volumn 10, Issue 5, 1999, Pages 543-547

  Gauthier, C A ^a   Bagley, J R ^b   Brockunier, L L ^b   France, Charles P ^a,c  

^a LOUISIANA STATE UNIV MEDICAL CENTER   (United States)

^b Ohmeda Inc   (United States)

^c LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Dependence; Mirfentanil; Morphine; Non opioid; Opioid; Pigeon; Rate decreasing; Tolerance

Indexed keywords

KETAMINE; MIRFENTANIL; MORPHINE; NALTREXONE;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG CROSS TOLERANCE; DRUG DEPENDENCE; DRUG EFFECT; DRUG SENSITIVITY; MORPHINE TOLERANCE; NONHUMAN; PIGEON;

EID: 0032860396     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008877-199909000-00012     Document Type: Article

References (12)

1. Adams JU, Holtzman SG (1990). Pharmacologic characterization of the sensitization to the rate-decreasing effects of naltrexone induced by acute opioid pretreatment in rats. J Pharmacol Exp Ther 253:483-489.
2. Bagley JR, Wynn RL, Rudo FG, Doorley BM, Spencer HK, Spaulding T (1989). New 4-(heteroanilido)piperidines, structurally related to the pure opioid agonist fentanyl, with agonist and/or antagonist properties. J Med Chem 32:663-671.
3. Craft RM, Picker MJ, Dykstra LA (1989). Differential cross-tolerance to opioid agonists in morphine-tolerant pigeons responding under a schedule of food presentation. J Pharmacol Exp Ther 249:386-393.
4. France CP, Woods JH (1985). Effects of morphine, naltrexone, and dextrorphan in untreated and morphine-treated pigeons. Psychopharmacology 85:377-382.
5. France CP, Winger G, Medzihradsky F, Seggel MR, Rice KC, Woods JH (1991). Mirfentanil, pharmacological profile of a novel fentanyl derivative with opioid and non-opioid effects. J Pharmacol Exp Ther 258:502-510.
6. France CP, Gerak LR, Flynn D et al. (1995). Behavioral effects and receptor binding affinities of fentanyl derivatives in rhesus monkeys. J Pharmacol Exp Ther 274:17-28.
7. Gauthier CA, Gerak LR, Bagley JR, Brockunier LL, France CP (1998). The rate-decreasing effects of fentanyl derivatives in pigeons before, during and after chronic morphine treatment. Psychopharmacology 137:67-73.
8. Hughes CE, Picker MJ, Dykstra LA (1995). Tolerance and cross-tolerance to the response rate-decreasing effects of mu opioids in morphine-maintained squirrel monkeys. Behav Pharmacol 6:776-784.
9. Mattox AJ, Picker MJ, Dykstra LA (1994). Pharmacological analysis of the rate-decreasing effects of mu and kappa opioids in pigeons. Psychopharmacology 113:457-462.
10. Meyer DR, Sparher SB (1977). Evidence of possible opiate dependence during the behavioral depressant action of a single dose of morphine. Life Sci 73:1087-1094.
11. Picker MJ, Yarbrough J (1991). Cross-tolerance and enhanced sensitivity to the response rate-decreasing effects of opioids with varying degrees of efficacy at the mu receptor. Psychopharmacology 105:459-466.
12. Valentino RJ, Herling S, Woods JH (1983). Discriminative stimulus effects of naltrexone in narcotic-naive and morphine-treated pigeons. J Pharmacol Exp Ther 224:307-313.