Bicuculline sensitive depressor response to ethanol infusion into the lateral hypothalamus

Alcohol

Volumn 19, Issue 2, 1999, Pages 177-185

  Phelix, C F ^a   Chen, H ^b   Trevino, G ^a   Lara, J R ^a   Liu, G ^a   Wayner, M J ^a  

^a UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^b WRIGHT STATE UNIVERSITY   (United States)

Author keywords

Alcohol; Arterial pressure; Bradycardia; Gamma amino butyric acid; Hypotension; Lateral hypothalamus; Serotonin

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BICUCULLINE; SEROTONIN;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; BRADYCARDIA; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; DENTATE GYRUS; GABAERGIC SYSTEM; HEART RATE; HYPERTENSION; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; LATERAL HYPOTHALAMUS; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; RAT;

ANIMALS; BICUCULLINE; BLOOD PRESSURE; CENTRAL NERVOUS SYSTEM DEPRESSANTS; ETHANOL; GABA ANTAGONISTS; HEART RATE; HYPOTHALAMIC AREA, LATERAL; MALE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032860172     PISSN: 07418329     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0741-8329(99)00037-3     Document Type: Article

References (98)

1. Allen G.V., Cechetto D.F. Functional and anatomical organization of cardiovascular pressor and depressor sites in the lateral hypothalamic area. II. Ascending projections. J. Comp. Neurol. 330:1993;421-438.
2. Abdel-Rahman A.A., Wooles W.R. Ethanol-induced hypertension involves impairment of baroreceptors. Hyperten. 10:1987;67-73.
3. Alexi T., Azmitia E.C. Ethanol stimulates [3H]5-HT high-affinity uptake by rat forebrain synaptosomes. role of 5-HT receptors and voltage channel blockers Brain Res. 544:1991;243-247.
4. Anderson P. Alcohol, cardiovascular diseases and public health policy. Novartis Found. Symp. 216:1998;237-248.
5. Andronova L.M., Ushakova M.M., Kudriavtsev R.V., Barkov N.K. Ethanol pharmacokinetics in narcotic actions and endogenous ethanol in female rats. Biull. Eksp. Biol. Med. 94:1982;60-62.
6. Atrens D.M., Becker F.T. Cardiovascular responses and lateral hypothalamic self-stimulation. anatomical differentiation and functional significance Brain Res. 129:1977;29-36.
7. Barone F.C., Cheng J.T., Wayner M.J. GABA inhibition of lateral hypothalamic neurons. role of reticular thalamic afferents Brain Res. Bull. 33:1994;699-708.
8. Barone F.C., Cheng J.T., Wayner M.J. Reticular thalamic inhibitory input to lateral hypothalamic neurons. a functional and histochemical determination Brain Res. Bull. 33:1994;575-582.
9. Barone F.C., Wayner M.J., Tsai W.H., Barash F.E. Effects of microiontophoretically applied chemicals on hypothalamic neural activity. Brain Res. Bull. 5:1980;325-332.
10. Beilin L.J., Hoffman P., Nilsson H., Skarphedinsson J., Folkow B. Effect of chronic ethanol consumption upon cardiovascular reactivity, heart rate and blood pressure in spontaneously hypertensive and Wistar-Kyoto rats. J. Hyperten. 10:1992;645-650.
11. Beilin L.J., Puddy I.B., Burke V. Alcohol and hypertension - kill or cure? J. Human Hyperten. 10:1996;S1-S5. (Suppl. 2).
12. Camargo C.A., Rimm E.B. Epidemiological research on moderate alcohol consumption and blood pressure. Zahkari S., Wassef M. Alcohol and the cardiovascular system. Research Monographs No. 31. 1996;25-62 National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD.
13. Carre G.P., Harley C.W. Population spike facilitation in the dentate gyrus following glutamate to the lateral supramammillary nucleus. Brain Res. 568:1991;307-310.
14. Chen H., Liu G., Wayner M.J., Phelix C.F. Serotonin increases while ethanol decreases arterial pressure and heart rate when infused into rat lateral hypothalamus. Abs. Soc. Neurosci. 23:1997;424.
15. Chen H., Liu G.H., Wayner M.J., Phelix C.F. Cardiovascular effects of microinfusion of ethanol in the lateral hypothalamus. Abs. Internat. Behav. Neurosci. Soc. 6:1997;40.
16. Chiu W.T., Kao T.Y., Lin M.T. Interleukin-1 receptor antagonist increases survival in rat heatstroke by reducing hypothalamic serotonin release. Neurosci. Lett. 202:1995;33-36.
17. Chueh F.Y., Hsieh M.T., Chen C.F., Lin M.T. Hypotensive and bradycardic effects of dl-tetrahydropalmatine mediated by decrease in hypothalamic serotonin release in the rat. Jpn. J. Pharmacol. 69:1995;177-180.
18. Cohen S.M., Martin D., Morrisett R.A., Wilson W.A., Swartzwelder H.S. Preconvulsant and anticonvulsant properties of ethanol. studies of electrographic seizures in vitro Brain Res. 601:1993;80-87.
19. Criqui M.H. Alcohol and coronary heart disease. consistent relationship and public health implications Clin. Chim. Acta. 246:1996;51-57.
20. Criqui M.H., Langer R.D., Reed D.M. Dietary alcohol, calcium, and potassium. Independent and combined effects on blood pressure. Circulation. 80:1989;609-614.
21. Czyzewska-Szafran H., Wutkiewicz M., Remiszewska M., Jastrzebski Z., Czarnecki A., Danysz A. Down-regulation of the GABA-ergic system in selected brain areas of spontaneously hypertensive rats (SHR). Pol. J. Pharmacol. Pharm. 41:1989;619-627.
22. Davidson D., Camara P., Swift R. Behavioral effects and pharmacokinetics of low-dose intravenous alcohol in humans. Alcohol Clin. Exp. Res. 21:1997;1294-1299.
23. Dent J.A., Galvin N.J., Stanfield B.B., Cowan W.M. The mode of termination of the hypothalamic projection to the dentate gyrus. an EM autoradiographic study Brain Res. 258:1983;1-10.
24. Dryden S., McCarthy H.D., Malabu U.H., Ware M., Williams G. Increased neuropeptide-Y concentrations in specific hypothalamic nuclei of the rat following treatment with methysergide. evidence that NPY may mediate serotonin's effects on food intake Peptides. 14:1993;791-796.
25. Ferraro T.N., Carrozza D.P., Vogel W.H. In Vivo microdialysis study of brain ethanol concentrations in rat following oral self-administration. Alcohol. Clin. Exp. Res. 15:1991;504-507.
26. Ferraro T.N., Weyers P., Carrozza D.P., Vogel W.H. Continuous monitoring of brain ethanol levels by intracerebral microdialysis. Alcohol. 7:1990;129-132.
27. Gelsema A.J., Roe M.J., Calaresu F.R. Neurally mediated cardiovascular responses to stimulation of cell bodies in the hypothalamus of the rat. Brain Res. 482:1989;67-77.
28. Gillman M.W., Cook N.R., Evans D.A., Rosner B., Hennekens C.H. Relationship of alcohol intake with blood pressure in young adults. Hypertension. 25:1995;1106-1110.
29. Gradin K., Qadri F., Nomikos G.G., Hillegaart V., Svensson T.H. Substance P injection into the dorsal raphe increases blood pressure and serotonin release in hippocampus of conscious rats. Euro. J. Pharm. 218:1992;363-367.
30. Han Y., Shaikh M.B., Siegel A. Ethanol enhances medial amygdaloid induced inhibition of predatory attack behaviour in the cat. role of GABAA receptors in the lateral hypothalamus Alcohol Alcohol. 32:1997;657-670.
31. Harburg E., Gleiberman L., Difranceisco W., Peele S. Towards a concept of sensible drinking and an illustration of measure. Alcohol Alcohol. 29:1994;439-450.
32. Harris R.A., Proctor W.R., McQuilkin S.J., Klein R.L., Mascia M.P., Whatley V., Whiting P.J., Dunwiddie T.V. Ethanol increases GABAA responses in cells stably transfected with receptor subunits. Alcohol Clin. Exp. Res. 19:1995;226-232.
33. Herrmann H.J., Rohde H.G., Schulze W., Eichhorn C., Luft F.C. Effect of noise stress and ethanol intake on hearts of spontaneously hypertensive rats. Basic Res. Cardiol. 89:1994;510-523.
34. Hori H., Haruta K., Nanki M., Sakamoto N., Uemura K., Matsubara T., Itoh K., Iguchi A. Pressor response induced by the hippocampal administration of neostigmine is suppressed by M1 muscarinic antagonist. Life Sci. 57:1995;1853-1859.
35. Howe P.R., Rogers P.F., Smith R.M. Antihypertensive effect of alcohol in spontaneously hypertensive rats. Hypertension. 12:1989;607-611.
36. Howe P.R., Rogers P.F., Smith R.M. Retarded development of hypertension in stroke-prone spontaneously hypertensive rats following chronic alcohol consumption. Clin. Exp. Pharmacol. Physiol. 12:1985;273-277.
37. Kantak K.M., Wayner M.J., Stein J.M. Effects of various periods of food deprivation on serotonin turnover in the lateral hypothalamus. Pharmacol. Biochem. Behav. 9:1978;529-534.
38. Kantak K.M., Wayner M.J., Stein J.M. Effects of various periods of food deprivation on serotonin synthesis in the lateral hypothalamus. Pharmacol. Biochem. Behav. 9:1978;535-541.
39. Kantak K.M., Wayner M.J., Stein J.M., Tilson H.A. Effects of imipramine on serotonin turnover in the lateral hypothalamus. Pharmacol. Biochem. Behav. 9:1978;693-696.
40. Kashani A., Rodriguez V., Phelix C.F., Wayner M.J. Angiotensin II in rat dorsal hippocampus increases blood pressure and heart rate. FASEB J. 10:1996;A408.
41. Kawano Y., Abe H., Kojima S., Ashida T., Imanishi M., Yoshimi H., Kimura G., Kuramochi M., Omae T. Acute depressor effect of alcohol in patients with essential hypertension. Hypertension. 20:1992;219-226.
42. Kohler C., Haglund L., Swanson L.W. A diffuse alpha MSH-immunoreactive projection to the hippocampus and spinal cord from individual neurons in the lateral hypothalamic area and zona incerta. J. Comp. Neurol. 223:1984;501-514.
43. Kunos G., Varga K. Alcohol effects on autonomic control of the cardiovascular system. Zahkari S., Wassef M. Alcohol and the cardiovascular system. Research Monographs No. 31. 1996;243-262 National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD.
44. Lara J., Chen H., Wayner M.J., Phelix C.F., Tracy H.A. Bicuculline in lateral hypothalamus blocks depressor/bradycardia from ethanol infusion in lateral hypothalamus. FASEB J. 12:1998;A67.
45. Le A.D., Israel Y. A simple technique for quantifying intoxication-induced by low doses of ethanol. Pharmacol. Biochem. Behav. 48:1994;229-234.
46. Lin L.S., Lin M.-T. Hypothalamic serotonin release and raised blood pressure after raphe stimulation in rats. Brain Res. Bull. 39:1996;305-309.
47. Mao L., Abdel-Rahman A.A. Blockade of L-glutamate receptors in the rostral ventrolateral medulla contributes to ethanol-evoked impairment of baroreflexes in conscious rats. Brain Res. Bull. 37:1995;513-521.
48. Monda M., Sullo A., De Luca V., Pellicano M.P., Viggiano A. L-threonine injection into PPC modifies food intake, lateral hypothalamic activity, and sympathetic discharge. Am. J. Physiol. 273:1997;R554-R559.
49. Moderate drinking. Alcohol Alert. 16:1992;1-4.
50. Nurmi M., Kiianmaa K., Sinclair J.D. Brain ethanol in AA, ANA, and Wistar rats monitored with one-minute microdialysis. Alcohol. 11:1994;315-321.
51. Office of Public Affairs: Treasury announces actions concerning labeling of alcoholic beverages. Treasury news from the Office of Public Affairs, RR-2937; February 5, 1999; www.atf.treas.gov/press/label_ab.htm .
52. Palmer A.J., Fletcher A.E., Bulpitt C.J., Beevers D.G., Coles E.C., Ledingham J.G., Petrie J.C., Webster J., Dollery C.T. Alcohol intake and cardiovascular mortality in hypertensive patients. report from the Department of Health Hypertension Care Computing Project J. Hypertension. 13:1995;957-964.
53. Paxinos G., Watson C. The rat brain in stereotaxic coordinates. 1986;Academic Press, Inc, San Diego.
54. Pergola P.E., Alper R.H. Effects of central serotonin on autonomic control of heart rate in intact and baroreceptor deficient rats. Brain Res. 582:1992;215-220.
55. Pergola P.E., Alper R.H. Vasopressin and autonomic mechanisms mediate cardiovascular actions of central serotonin. Am. J. Physiol. 260:1991;R1188-R1193.
56. Privette T.H., Wang J.Q., Ingenito A.J., Terrian D.M. Dentate granule cells as a central cardioregulatory site in the rat. Brain Res. 656:1994;295-301.
57. Remiszewska M., Jastrzebski Z., Czyzewska-Szafran H., Wutkiewicz M. Enhancement of GABAergic system activity by metoprolol in spontaneously hypertensive rats. Eur. J. Pharmacol. 250:1993;355-360.
58. Remiszewska M., Jastrzebski Z., Czyzewska-Szafran H., Wutkiewicz M., Czarnecki A. Increased activity of the GABAergic system in selected brain areas after chronic propanolol treatment in spontaneously hypertensive rats. Biochem. Pharmacol. 44:1992;465-470.
59. Roberts K.A., Wright J.W., Harding J.W. GABA and bicuculline-induced blood pressure changes in spontaneously hypertensive rats. J. Cardio. Pharmacol. 21:1993;156-162.
60. Ruit K.G., Neafsey E.J. Cardiovascular and respiratory responses to electrical and chemical stimulation of the hippocampus in anesthetized and awake rats. Brain Res. 457:1988;310-321.
61. Russ R., Abdel-Rahman A.R., Wooles W.R. Role of the sympathetic nervous system in ethanol-induced hypertension in rats. Alcohol. 8:1991;301-307.
62. Sacco R.L., Elkind M., Boden-Albala B., Lin I.F., Kargman D.E., Hauser W.A., Shea S., Paik M.C. The protective effect of moderate alcohol consumption on ischemic stroke. JAMA. 281:1999;53-60.
63. Sanderson J.E., Jones J.V., Graham D.I. Effect of chronic alcohol ingestion on the heart and blood pressure of spontaneously hypertensive rats. Clin. Exp. Hypertension. 5:1983;673-689.
64. Sasaki S., Nakata T., Kawasaki S., Hayashi J., Oguro M., Takeda K., Nakagawa M. Chronic central GABAergic stimulation attenuates hypothalamic hyperactivity and development of spontaneous hypertension in rats. J. Cardio. Pharmacol. 15:1990;706-713.
65. Saydoff J.A., Rittenhouse P.A., Carnes M., Armstrong J., Van De Kar L.D., Brownfield M.S. Neuroendocrine and cardiovascular effects of serotonin. selective role of brain angiotensin on vasopressin Am. J. Physiol. 270:1996;E513-E521.
66. Schlicht I., Falk S., Krossin A., Mohnhaupt A. Lifetime prolongation in voluntary alcohol-consuming rats (SHR) treated with clofibrate. Alcohol. 9:1992;139-148.
67. Segal M. A potent inhibitory monosynaptic hypothalamo-hippocampal connection. Brain Res. 162:1979;137-141.
68. Shekhar A., Keim S.R., Simon J.R., McBride W.J. Dorsomedial hypothalamic GABA dysfunction produces physiological arousal following sodium lactate infusions. Pharmacol. Biochem. Behav. 55:1996;249-256.
69. Simon H. Patient-directed, nonprescription approach to cardiovascular disease. Arch. Int. Med. 154:1994;2283-2296.
70. Singer G., Armstrong S., Wayner M.J. Effects of norepinephrine applied to the lateral hypothalamus on schedule induced polydipsia. Pharmacol. Biochem. Behav. 3:1975;869-872.
71. Singewald N., Guo L.J., Schneider C., Kaehler S., Philippu A. Serotonin outflow in the hypothalamus of conscious rats. origin and possible involvement in cardiovascular control Euro. J. Pharmacol. 294:1995;787-793.
72. Spanagel R., Montkowski A., Allingham K., Stohr T., Shoaib M, Holsboer F., Landgraf R. Anxiety. a potential predictor of vulnerability to the initiation of ethanol self-administration in rats Psychopharmacol. 122:1995;369-373.
73. Strickland J.A., Wooles W.R. Blood ethanol level and physiological measurements during ethanol-induced hypertension. Alcohol. 6:1989;109-114.
74. Takada R., Saito K., Matsuura H., Inoki R. Effect of ethanol on hippocampal GABA receptors in the rat brain. Alcohol. 6:1989;115-119.
75. Tatsuta H., Arita H. Nonadrenergic relaxation of the cat cervical trachea evoked by stimulation of the lateral hypothalamic area. Neurosci. Res. 26:1996;315-322.
76. Thun M.J., Pet R., Lopez A.D., Monaco J.H., Henley S.J., Heath C.W. Jr., Doll R. Alcohol consumption and mortality among middle-aged and elderly U.S. adults. N. Eng. J. Med. 337:1997;1705-1714.
77. Ticku M.K., Lowrimore P., Lehoullier P. Ethanol enhances GABA-induced 36Cl-influx in primary spinal cord cultured neurons. Brain Res. Bull. 17:1986;123-126.
78. Trevino J., Chen H., Phelix C.F., Wayner M.J. Depressor- bradycardia response to ethanol infusion into rat lateral hypothalamus is dose dependent. FASEB J. 12:1998;A741.
79. Varga K., Kunos G. Inhibition of baroreflex bradycardia by ethanol involves both GABAA and GABAB receptors in the brainstem of the rat. Eur. J. Pharmacol. 214:1992;223-232.
80. Wallace R.B., Barrett-Connor E., Criqui M., Wahl P., Hoover J., Hunninghake D., Heiss G. Alterations in blood pressure associated with combined alcohol and oral contraceptive use. the lipid research clinics prevalence study J. Chronic Dis. 35:1982;251-257.
81. Wallace R.B., Lynch C.F., Pomrehn P.R., Criqui M.H., Heiss G. Alcohol and hypertension. epidemiologic and experimental consideration The Lipid Research Clinics Program. Circulation. 64:1981;41-47.
82. Wang J.Q., Ingenito A.J. Cardiovascular effects of microinjection of dynorphin A(1-8) into the hippocampus in conscious, spontaneously hypertensive Wistar Kyoto rats. Clin. Exp. Hypertension. 16:1994;229-243.
83. Wang J.Q., Ingenito A.J. Centrally mediated cardiovascular actions of dynorphin A(1-8) on rat hippocampal formation. JPET. 261:1992;678-685.
84. Wang J.Q., Ingenito A.J. Comparative effects of intrahippocampal injections of dynorphin A(1-8), dynorphin A(1-13), dynorphin A(1-17), U-50,488H, and dynorphin B on blood pressure and heart rate in spontaneously hypertensive and normotensive Wistar Kyoto rats. Peptides. 15:1994;125-132.
85. Wayner M.J. The lateral hypothalamus and adjunctive drinking. Prog. Brain Res. 42:1974;371-394.
86. Wayner M.J., Kantak K.M., Barone F.C., DeHaven D.L., Wayner M.J. III, Cook R.C. Effects of LH kainic acid infusion on ingestion and autonomic activity. Physiol. Behav. 27:1979;369-376.
87. Wayner M.J., Chitwood R., Armstrong D.L., Phelix C. Ethanol affects hypothalamic neurons projecting to the hippocampus and inhibits dentate granule cell LTP. Alcohol. 14:1997;1-7.
88. Wayner M.J., Ono T., Nolley D. Effects of ethyl alcohol on central neurons. Pharmacol. Biochem. Behav. 3:1975;499-506.
89. Wayner, M. J.; Ono, T.; Nolley, D.; de Young, A.: Effects of ethyl alcohol, angiotensin and several essential amino acids on the lateral hypothalamus. In: Lederis, K.; Cooper, K. E., eds. Recent studies of hypothalamic function. S. Karger: Basel; 1974:232-250.
90. Wayner M.J., Phelix C.F., Armstrong D.L. Lateral hypothalamic stimulation inhibits dentate gyrus granule cell LTP. Direct connections Brain Res. Bull. 43:1997;5-15.
91. Wible J.H., Luft F.C., DiMicco J.A. Hypothalamic GABA suppresses sympathetic outflow to the cardiovascular system. Am. J. Physiol. 254:1988;R680-R687.
92. Wong S.M., Fong E., Tauck D.L., Kendig J.J. Ethanol as a general anesthetic. actions in spinal cord Eur. J. Pharmacol. 329:1997;121-127.
93. Wong S.M., Tauck D.L., Fong E.G., Kendig J.J. Glutamate receptor-mediated hyperexcitability after ethanol exposure in isolated neonatal rat spinal cord. J. Pharmacol. Exp. Ther. 285:1998;201-207.
94. Wright J.W., Morseth S.L., Abhold R.H., Harding J.W. Elevations in plasma angiotensin II with prolonged ethanol treatment in rats. Pharmacol. Biochem. Behav. 24:1986;813-818.
95. Yamori Y., Okamoto K. Hypothalamic tonic regulation of blood pressure in spontaneously hypertensive rats. Jap. Circ. J. 33:1969;509-519.
96. Yap M., Mascord D.J., Starmer G.A., Whitfield J.B. Studies on the chronopharmacology of ethanol. Alcohol Alcohol. 28:1993;17-24.
97. Yoshimoto K., Komura S. Monitoring of ethanol levels in the rat nucleus accumbens by brain microdialysis. Alcohol Alcohol. 28:1993;171-174.
98. Zhang X., Abdel-Rahman A.A., Wooles W.R. Impairment of baroreceptor reflex control of heart rate but not sympathetic efferent discharge by central neuroadministration of ethanol. Hypertension. 14:1989;282-292.