Nitrile hydratase from Rhodococcus erythropolis: Metabolization of steroidal compounds with a nitrile group

Steroids

Volumn 64, Issue 8, 1999, Pages 535-540

  Kaufmann, Günter ^a   Dautzenberg, Horst ^b   Henkel, Harry ^a   Müller, Gerd ^a   Schäfer, Thomas ^b   Undeutsch, Bernd ^a   Oettel, Michael ^a  

^a BAYER PHARMA AG   (Germany)

^b UNIVERSITY OF POTSDAM   (Germany)

Author keywords

Microbial transformation; Nitrile hydratase; Progesterone receptor; Progestin; Steroid aromatization

Indexed keywords

DIENOGEST; ESTRANE DERIVATIVE; ESTROGEN RECEPTOR; NITRILE HYDRATASE; PROGESTERONE RECEPTOR;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHEMICAL REACTION KINETICS; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ENZYME ACTIVITY; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE ACTION; HYDROLYSIS; IN VITRO STUDY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; RABBIT; REACTION ANALYSIS; RHODOCOCCUS; STEROID METABOLISM; THIN LAYER CHROMATOGRAPHY;

ANIMALS; BIOTRANSFORMATION; DRUG EVALUATION, PRECLINICAL; ESTRADIOL; FERMENTATION; HYDRO-LYASES; HYDROLYSIS; NANDROLONE; PROGESTERONE; PYRIDINES; RABBITS; RECEPTORS, ESTROGEN; RHODOCOCCUS; STRUCTURE-ACTIVITY RELATIONSHIP;

ERYTHROPOLIS; RHODOCOCCUS ERYTHROPOLIS;

EID: 0032859880     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0039-128X(99)00028-8     Document Type: Article

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