A polymorphism in the CYP17 gene is associated with male breast cancer

British Journal of Cancer

Volumn 81, Issue 1, 1999, Pages 141-143

  Young, I E ^a   Kurian, K M ^a   Annink, C ^a,d   Kunkler, I H ^b   Anderson, V A ^c   Cohen, B B ^c   Hooper, M L ^a   Wyllie, A H ^a,e   Steel, C M ^c  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

^b WESTERN GENERAL HOSPITAL   (United Kingdom)

^c UNIVERSITY OF ST ANDREWS   (United Kingdom)

^d Dept of Biology and Med Lab E   (Netherlands)

^e UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

CYP17 polymorphism; Male breast cancer

Indexed keywords

CYTOCHROME P450;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER RISK; CONTROLLED STUDY; GENETIC POLYMORPHISM; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; ANDROGENS; BREAST NEOPLASMS; BREAST NEOPLASMS, MALE; CASE-CONTROL STUDIES; ESTROGENS; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; STEROID 17-ALPHA-HYDROXYLASE;

EID: 0032858923     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6690663     Document Type: Article

References (14)

1. Brentano ST, Picado-Leonard J, Mellon SH, Moore CCD and Miller WL (1990) Tissue-specific, cyclic adenosine 3′,5′ -monophosphate-induced, and phorbol ester-repressed transcription from the human P450c 17 promoter in mouse cells. Mol Endocrinol 4: 1972-1979
2. Carey AH, Waterworth D, Patel K, White D, Little J, Novelli P, Franks S and Williamson R (1994) Polycystic ovaries and premature male pattern baldness are associated with one allete of the steroid metabolism gene CYP17. Hum Mol Genet 3: 1873-1876
3. Dunning AM, Healey CS, Pharoah PDP, Foster NA, Lipscombe JM, Redman KL, Easton DF, Day NE and Ponder BAJP (1998) No association between a polymorphism in the steroid metabolism gene Cyp17 and risk of breast cancer. Br J Cancer 77: 2045-2047
4. Feigelson HS, Ross RK, Yu MC, Coetzee GA, Reichardt JKV and Henderson BF. (1996) Genetic susceptibility to cancer from exogenous and endogenous exposures. J Cell Biochem Suppl 25: 15-22
5. Fergelson HS, Coetzee GA, Kolonel LN, Ross RK and Henderson BE (1997) A polymorphism in the CYP17 gene increases the risk of breast cancer. Cancer Res 57: 1063-1065
6. Feigelson HS, Shames LS, Pike MC, Coetzee GA, Stanczyk FZ and Henderson BF. (1998) Cytochrome P450c17α gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations. Cancer Res 58: 585-587
7. Friedman LS, Gayther SA, Kurosaki T, Gordon D, Noble B, Casey G, Ponder BAJP and Anton-Culver H (1997) Mutation analysis of BRCA1 and BRCA2 in a male breast cancer population. Am J Hum Genet 60: 313-319
8. Jackson AW, Muldal S, Ockey CH and O'Connor PJ (1965) Carcinoma of the male breast in association with the Klinefelter syndrome. Br Med J 1: 223-225
9. Lobaccaro JM, Lumbroso S, Belon C, Galtier-Dereure F, Bringer J, Lesimple T, Heron JF, Pujol H and Sultan C (1993) Male breast cancer and the androgen receptor gene (Letter). Nat Genet 5(2): 109-110
10. Miki Y, Swensen J, Shattuck-Eidens D, Futreal PA, Harshman K, Tavtigian S, Liu Q, Cochran C, Bennett LM, Ding W, Bell R, Rosental J, Hussey C, Tran T, McClure M, Frye C, Hattier T, Phelps R, Haugen-Strano R, Katcher H, Gholami Z, Shaffer D, Stone S, Bayer S, Wray C, Bogden R, Dayananth P, Ward J, Tonin P, Narod S, Bristow PK, Norris FH, Helvering L, Morrison P, Rosteck P, Lai M, Barrett JC, Lewis C, Neuhausen S, Cannon-Albright L, Goldgar D, Wiseman R, Kamb A and Skolnick MHA (1994) A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266: 66-71
11. Picado-Leonard J and Miller WL (1987) Cloning and sequence of the human gene for P450c 17 (steroid 17α-hydroxylase/17.20-lyase): similarity with the gene for P450c21. DNA 6(5): 439-448
12. Thorlacius S, Olafsdottir G, Tryggvadotlir L, Neuhausen S, Jonasson JG, Tavtigian S, Tulinius H. Öginundsdottir HM and Eyfjörd JE (1996) A single BRCA2 mutation in male and female breast cancer families from Iceland with varied cancer phenotypes. Nat Genet 13: 117-119
13. Wooster R, Mangion J, Ecles R, Smith S, Mitchell D, Averill D, Barrett-Lee P, Easton DF, Ponder BAJP and Stratton MR (1992) A germline mutation in the androgen receptor gene in two brothers with breast cancer and Reifenstein syndrome. Nat Genet 2(2): 132-134
14. Wooster R, Bignell G, Lancaster J, Swift S, Seal S, Mangion J, Collins N, Gregory S, Gumbs C, Micklem G, Barfoot R, Hamoudi R, Patel S, Rice C, Biggs P, Hashim Y, Smith A, Connor F, Arason A, Gudmundson J, Ficence D, Kelsell D, Ford D, Tonin P, Bishop DT, Spurr NK, Ponder BAJP, Eeles R, Petu J, Devilee P, Cornelisse C, Lynch H, Narod S, Lenoir G, Egilsson V, Barkadottir RB, Easton DF, Bentley DR, Futreal PA, Ashworth A and Stratton MR (1995). Identification of the breast cancer susceptibility gene BRCA2. Nature 378: 789-792