-
1
-
-
0023899991
-
The Role of Aldose Reductase in the Development of Diabetic Complications
-
Kador, P. F. (1988). The Role of Aldose Reductase in the Development of Diabetic Complications. Med. Res. Rev , 8, 325-352.
-
(1988)
Med. Res. Rev
, vol.8
, pp. 325-352
-
-
Kador, P.F.1
-
2
-
-
0027934146
-
Aldose Reductase Inhibitors and their Potential for the Treatment of Diabetic Complications
-
Tomlinson, D. R., Stevens, E. J. and Diemel, L. T. (1994). Aldose Reductase Inhibitors and their Potential for the Treatment of Diabetic Complications, Trends Pharmacol. Sci , 15, 293-297
-
(1994)
Trends Pharmacol. Sci
, vol.15
, pp. 293-297
-
-
Tomlinson, D.R.1
Stevens, E.J.2
Diemel, L.T.3
-
3
-
-
0025967888
-
Novel, Potent Aldose Reductase Inhibitors: 3,4-Dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-1- phthalazineacetic Acid (Zopolrestat) and Congeners
-
Mylari, B. L , Larson, E R., Beyer, T. A., Zembrowski, W. J., Aldinger, C. E., Dee, M. F., Siegel, T. W. and Singleton, D. H. (1991). Novel, Potent Aldose Reductase Inhibitors: 3,4-Dihydro-4-oxo-3-[[5-(trifluoromethyl)-2-benzothiazolyl]methyl]-1- phthalazineacetic Acid (Zopolrestat) and Congeners, J. Med. Chem., 34, 108-122.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 108-122
-
-
Mylari, B.L.1
Larson, E.R.2
Beyer, T.A.3
Zembrowski, W.J.4
Aldinger, C.E.5
Dee, M.F.6
Siegel, T.W.7
Singleton, D.H.8
-
4
-
-
0026012419
-
Syntheses of Tolrestat Analogues Containing Additional Substituents in the Ring and Their Evaluation as Aldose Reductase Inhibitors. Identification of Potent, Orally Active 2-Fluoro Derivatives
-
Wrobel, J., Millen, J., Sredy, J., Dietrich, A., Gorham, B. J., Malamas, M., Kelly, J. M., Bauman, J. G., Harrison, M. C., Jones, L. R., Guinosso, C. and Sestanj, K. (1991). Syntheses of Tolrestat Analogues Containing Additional Substituents in the Ring and Their Evaluation as Aldose Reductase Inhibitors. Identification of Potent, Orally Active 2-Fluoro Derivatives, J. Med. Chem., 34, 2504-2520.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 2504-2520
-
-
Wrobel, J.1
Millen, J.2
Sredy, J.3
Dietrich, A.4
Gorham, B.J.5
Malamas, M.6
Kelly, J.M.7
Bauman, J.G.8
Harrison, M.C.9
Jones, L.R.10
Guinosso, C.11
Sestanj, K.12
-
5
-
-
0006206253
-
Development of Epalrestat (Kinedak), Aldose Reductase Inhibitor
-
Kawamura, M and Hamanaka, N. (1997). Development of Epalrestat (Kinedak), Aldose Reductase Inhibitor, J. Synth. Org, Chem., Japan, 55, 651-657.
-
(1997)
J. Synth. Org, Chem., Japan
, vol.55
, pp. 651-657
-
-
Kawamura, M.1
Hamanaka, N.2
-
6
-
-
0028219573
-
Molecular Modeling Studies of Aldose Reductase Inhibitors
-
Lee, Y. S., Pearlstein, R. and Kador, P. F. (1994). Molecular Modeling Studies of Aldose Reductase Inhibitors, J Med. Chem., 37, 787-792.
-
(1994)
J Med. Chem.
, vol.37
, pp. 787-792
-
-
Lee, Y.S.1
Pearlstein, R.2
Kador, P.F.3
-
7
-
-
0031058373
-
Highly Selective Aldose Reductase Inhibitors. 3. Structural Diversity of 3-(Arylmethyl)-2,4,5-trioxoimidazolidine-1-acetic Acids
-
Kotani, T., Nagaki, Y., Ishii, A., Konishi, Y., Yago, H., Suehiro, S., Okukado, N. and Okamoto, K. (1997). Highly Selective Aldose Reductase Inhibitors. 3. Structural Diversity of 3-(Arylmethyl)-2,4,5-trioxoimidazolidine-1-acetic Acids, J. Med. Chem., 40, 684-694.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 684-694
-
-
Kotani, T.1
Nagaki, Y.2
Ishii, A.3
Konishi, Y.4
Yago, H.5
Suehiro, S.6
Okukado, N.7
Okamoto, K.8
-
8
-
-
0026645207
-
Biological Activities and Quantitative Structure-Activity Relationships of Spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones as Aldose Reductase Inhibitors
-
Yamagishi, M., Yamada, Y., Ozaki, K., Asao, M., Shimizu, R , Suzuki, M., Matsumoto, M., Matsuoka, Y. and Matsumoto, K (1992). Biological Activities and Quantitative Structure-Activity Relationships of Spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones as Aldose Reductase Inhibitors, J. Med. Chem., 35, 2085-2094.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 2085-2094
-
-
Yamagishi, M.1
Yamada, Y.2
Ozaki, K.3
Asao, M.4
Shimizu, R.5
Suzuki, M.6
Matsumoto, M.7
Matsuoka, Y.8
Matsumoto, K.9
-
9
-
-
0040914011
-
ρ - σ - π Analysis. A Method for the Correlation of Biological Activity and Chemical Structure
-
Hansch, C. and Fujita, T. (1964). ρ - σ - π Analysis. A Method for the Correlation of Biological Activity and Chemical Structure, J. Am. Chem Soc., 86, 1616-1626.
-
(1964)
J. Am. Chem Soc.
, vol.86
, pp. 1616-1626
-
-
Hansch, C.1
Fujita, T.2
-
10
-
-
33749000228
-
A New Substituent Constant, π, Derived from Partition Coefficients
-
Fujita. T., Iwasa, J. and Hansch, C. (1964). A New Substituent Constant, π, Derived from Partition Coefficients, J. Am. Chem. Soc., 86, 5175-5180
-
(1964)
J. Am. Chem. Soc.
, vol.86
, pp. 5175-5180
-
-
Fujita, T.1
Iwasa, J.2
Hansch, C.3
-
11
-
-
0003792915
-
-
Washington, DC: American Chemical Society
-
Hansch, C. and Leo, A. (1995). Exploring QSAR, Washington, DC: American Chemical Society
-
(1995)
Exploring QSAR
-
-
Hansch, C.1
Leo, A.2
-
12
-
-
0000910008
-
-
edited by E. J. Ariens, New York: Academic Press
-
Verloop, A., Hoogenstraaten, W. and Tipker, J. (1976). In Drug Design edited by E. J. Ariens, New York: Academic Press, VI, pp. 165-207.
-
(1976)
Drug Design
, vol.6
, pp. 165-207
-
-
Verloop, A.1
Hoogenstraaten, W.2
Tipker, J.3
-
14
-
-
84889230052
-
-
The crystal structure data of 10 has been deposited to the Cambridge Crystallographic Data Center
-
The crystal structure data of 10 has been deposited to the Cambridge Crystallographic Data Center (http://www.ccdc. cam.ac.uk).
-
-
-
-
15
-
-
0022381194
-
Synthesis, Absolute Configuration, and Conformation of the Aldose Reductase Inhibitor Sorbinil
-
Sarges, R., Bordner, J., Dominy, B. W., Peterson, M. J. and Whipple, E. B. (1985). Synthesis, Absolute Configuration, and Conformation of the Aldose Reductase Inhibitor Sorbinil, J. Med. Chem., 28, 1716-1720.
-
(1985)
J. Med. Chem.
, vol.28
, pp. 1716-1720
-
-
Sarges, R.1
Bordner, J.2
Dominy, B.W.3
Peterson, M.J.4
Whipple, E.B.5
-
16
-
-
0025390935
-
MOPAC: A Semiempirical Molecular Orbital Program
-
Stewart, J. J. P. (1990). MOPAC: A Semiempirical Molecular Orbital Program, J. Compui.-Aided Mol. Des., 4, 1-105.
-
(1990)
J. Compui.-Aided Mol. Des.
, vol.4
, pp. 1-105
-
-
Stewart, J.J.P.1
-
17
-
-
0842341771
-
AMI: A New General Purpose Quantum Mechanical Molecular Model
-
Dewar, M. J. S., Zoebisch, E. G., Healy, E. F. and Stewart, J. J. P. (1985). AMI: A New General Purpose Quantum Mechanical Molecular Model, J. Am. Chem. Soc., 107, 3902-3909.
-
(1985)
J. Am. Chem. Soc.
, vol.107
, pp. 3902-3909
-
-
Dewar, M.J.S.1
Zoebisch, E.G.2
Healy, E.F.3
Stewart, J.J.P.4
-
18
-
-
24444468650
-
Ground States of Molecules. 38. The MNDO Method Approximations and Parameters
-
Dewar, M. J. S. and Thiel, W. (1977). Ground States of Molecules. 38. The MNDO Method Approximations and Parameters, J Am. Chem. Soc., 99, 4899-4907.
-
(1977)
J Am. Chem. Soc.
, vol.99
, pp. 4899-4907
-
-
Dewar, M.J.S.1
Thiel, W.2
-
19
-
-
0004301669
-
-
Tripos, Inc. S. Hanley Road, St. Louis, MO 63144-2913, U.S.A.
-
SYBYL molecular modeling software. Tripos, Inc. 1699, S. Hanley Road, St. Louis, MO 63144-2913, U.S.A. (http://www.tripos com/).
-
(1699)
SYBYL Molecular Modeling Software
-
-
-
20
-
-
0021828899
-
Aldose Reductase Inhibitors: A Potential New Class of Agents for the Pharmacological Control of Certain Diabetic Complications
-
Kador, P. F., Kinoshita, J. H. and Sharpless, N. E. (1985). Aldose Reductase Inhibitors: A Potential New Class of Agents for the Pharmacological Control of Certain Diabetic Complications, J. Med. Chem., 28, 841-849.
-
(1985)
J. Med. Chem.
, vol.28
, pp. 841-849
-
-
Kador, P.F.1
Kinoshita, J.H.2
Sharpless, N.E.3
-
21
-
-
0023751431
-
Comparative Molecular Field Analysis (CoMFA). 1 Effect of Shape on Binding of Steroids to Carrier Proteins
-
Cramer, III, R. D., Patterson, D. E. and Bunce, J. D.(1988). Comparative Molecular Field Analysis (CoMFA). 1 Effect of Shape on Binding of Steroids to Carrier Proteins, J. Am. Chem Soc , 110, 5959-5967.
-
(1988)
J. Am. Chem Soc
, vol.110
, pp. 5959-5967
-
-
Cramer III, R.D.1
Patterson, D.E.2
Bunce, J.D.3
-
22
-
-
0026292147
-
HINT: A New Method of Eempirical Hydrophobic Field Calculation for CoMFA
-
Kellog, G. E-, Semus, S. and Abraham, D. J. (1991). HINT: A New Method of Eempirical Hydrophobic Field Calculation for CoMFA, J. Comput.-Aided Mol. Design, 5, 545-552.
-
(1991)
J. Comput.-Aided Mol. Design
, vol.5
, pp. 545-552
-
-
Kellog, G.E.1
Semus, S.2
Abraham, D.J.3
-
23
-
-
84889179589
-
-
eduSoft, LC. Ashland, VA 23005, U.S.A.
-
eduSoft, LC. Ashland, VA 23005, U.S.A. (http://www eslc. vabiotech.com/)
-
-
-
-
24
-
-
0027978699
-
3D-QSAR of Human Immunodeficiency Virus (I) Protease Inhibitors. III. Interpretation of CoMFA Results
-
Opera, T. I., Waller, C. L. and Marshall, G. R. (1994). 3D-QSAR of Human Immunodeficiency Virus (I) Protease Inhibitors. III. Interpretation of CoMFA Results, Drug Des. Discovery, 12, 29-51.
-
(1994)
Drug Des. Discovery
, vol.12
, pp. 29-51
-
-
Opera, T.I.1
Waller, C.L.2
Marshall, G.R.3
-
25
-
-
0042292781
-
Partial Least-Squares Method for Spectrofluorimetric Analysis of Mixtures of Humic Acid and Ligninsulfonate
-
Lindberg, W. and Persson, J.-A. (1983). Partial Least-Squares Method for Spectrofluorimetric Analysis of Mixtures of Humic Acid and Ligninsulfonate, Anal. Chem., 55, 643-648.
-
(1983)
Anal. Chem.
, vol.55
, pp. 643-648
-
-
Lindberg, W.1
Persson, J.-A.2
-
26
-
-
0031570301
-
A 'Specificity' Pocket Inferred from the Crystal Structures of the Complexes of Aldose Reductase with the Pharmaceutically Important Inhibitors Tolrestat and Sorbinil
-
Urzhumtsev, A., Tete-Favier, F., Mitschler, A., Barbanton, J, Barth, P., Urzhumtseva, L., Biellmann, J.-F., Podjarny, A. D. and Moras, D. (1997). A 'Specificity' Pocket Inferred from the Crystal Structures of the Complexes of Aldose Reductase with the Pharmaceutically Important Inhibitors Tolrestat and Sorbinil, Structure, 5, 601-612.
-
(1997)
Structure
, vol.5
, pp. 601-612
-
-
Urzhumtsev, A.1
Tete-Favier, F.2
Mitschler, A.3
Barbanton, J.4
Barth, P.5
Urzhumtseva, L.6
Biellmann, J.-F.7
Podjarny, A.D.8
Moras, D.9
-
27
-
-
84889178705
-
-
Protein Data Bank (PDB), Biology Department, Building 463, Brookhaven National Laboratory, Upton, NY 11973-5000, U.S.A.
-
Protein Data Bank (PDB), Biology Department, Building 463, Brookhaven National Laboratory, Upton, NY 11973-5000, U.S.A. (http://pdb.pdb.bnl.gov/).
-
-
-
-
28
-
-
84889222299
-
-
Molecular Simulations, Inc., 9685, Scranton Road, San Diego, CA 92191-3752, U.S.A.
-
Insight II molecular modeling and simulation software. Molecular Simulations, Inc., 9685, Scranton Road, San Diego, CA 92191-3752, U.S.A. (http://www.msi.com/).
-
Insight II Molecular Modeling and Simulation Software
-
-
-
29
-
-
0028598623
-
Determinants of Protein Side-chain Packing
-
Tanimura, R., Kidera, A. and Nakamura, H. (1994). Determinants of Protein Side-chain Packing, Protein Sci., 3, 2358-2365.
-
(1994)
Protein Sci.
, vol.3
, pp. 2358-2365
-
-
Tanimura, R.1
Kidera, A.2
Nakamura, H.3
-
30
-
-
84988053694
-
An All Atom Force Field for Simulations of Proteins and Nucleic Acids
-
Weiner, S. J., Kollman, P. A., Ngoyen, D. T. and Case, D. A. (1986). An All Atom Force Field for Simulations of Proteins and Nucleic Acids, J. Comput. Chem., 7, 230-252.
-
(1986)
J. Comput. Chem.
, vol.7
, pp. 230-252
-
-
Weiner, S.J.1
Kollman, P.A.2
Ngoyen, D.T.3
Case, D.A.4
|