Reversed-phase liquid chromatographic separation of complex samples by optimizing temperature and gradient timeI. Peak capacity limitations

Journal of Chromatography A

Volumn 857, Issue 1-2, 1999, Pages 1-20

  Dolan, J W ^a   Snyder, L R ^a   Djordjevic, N M ^b   Hill, D W ^c   Waeghe, T J ^d  

^a LC RESOURCES   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

^c UNIVERSITY OF CONNECTICUT   (United States)

^d DUPONT COMPANY   (United States)

Author keywords

Computer simulation; Gradient elution; Mobile phase composition; Optimization; Peak capacity; Resolution; Selectivity; Temperature effects

Indexed keywords

4 AMINOPHENAZONE; ANALYTE; BENZATROPINE; BENZOYLECGONINE; BROMPHENIRAMINE; CINCHOCAINE; CINCHONIDINE; COCAINE; COLCHICINE; CYCLOBENZAPRINE; DANAZOL; DIAZEPAM; DIPHENHYDRAMINE; DOXAPRAM; EPHEDRINE; FENCAMFAMIN; FLUNITRAZEPAM; FLUNIXIN; HALAZEPAM; HERBICIDE; HYDROCODONE; IMIPRAMINE; LEVORPHANOL; MAZINDOL; MEPYRAMINE; MESORIDAZINE; METHADONE; METOPROLOL; NADOLOL; NALORPHINE; NAPHAZOLINE; NEFOPAM; NIFLUMIC ACID; NITRAZEPAM; NORCODEINE; OXAZEPAM; PHENACETIN; PHENAZONE; PRAZEPAM; PROPIONYLPROCAINAMIDE; RANITIDINE; RESCINNAMINE; SALBUTAMOL; SOLVENT; TAMOXIFEN; THEBAINE; TRIBENZYLAMINE; UNCLASSIFIED DRUG; ZOXAZOLAMINE;

ANALYTIC METHOD; ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; MOBILE PHASE; PHASE SEPARATION; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REVERSED PHASE LIQUID CHROMATOGRAPHY; SAMPLE; TEMPERATURE;

CHROMATOGRAPHY, LIQUID; TEMPERATURE; TIME FACTORS;

EID: 0032857711     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9673(99)00765-7     Document Type: Article

References (24)

1. Snyder L.R., Kirkland J.J., Glajch J.L. Practical HPLC Method Development. 2nd ed. 1997;Wiley-Interscience, New York.
2. Davis J.M., Giddings J.C. Anal. Chem. 53:1983;418.
3. Glajch J.L., Kirkland J.J., Squire K.M., Minor J.M. J. Chromatogr. 199:1980;57.
4. Weyland J.W., Bruins C.H.P., Doornbos D.A. J. Chromatogr. Sci. 22:1984;31.
5. Kong R.C., Sachok B., Deming S.N. J. Chromatogr. 199:1980;307.
6. DeStefano J.J., Lewis J.A., Snyder L.R. LC·GC Mag. 10:1992;130.
7. Bourguignon B., de Agular P.F., Khots M.S., Massart D.L. Anal. Chem. 66:1994;893.
8. Dolan J.W., Snyder L.R., Djordjevic N.M., Hill D.W., Saunders D.L., Van Heukelem L., Waeghe T.J. J. Chromatogr. A. 803:1998;1.
9. Dolan J.W., Snyder L.R., Djordjevic N.M., Hill D.W., Waeghe T.J. J. Chromatogr. A. 857:1999;21.
10. Herman D.P., Billiet H.A.H., DeGalan L. Anal. Chem. 58:1986;2999.
11. Snyder L.R., Dolan J.W. Adv. Chromatogr. 38:1998;115.
12. Kiel J.S., Morgan S.L., Abramson R.K. J. Chromatogr. 485:1989;585.
13. Glajch J.L., Gluckman J.C., Charikovsky J.G., Minor J.M., Kirkland J.J. J. Chromatogr. 318:1985;23.
14. Dolan J.W., Snyder L.R., Saunders D.L., Van Heukelem L. J. Chromatogr. A. 803:1998;33.
15. Snyder L.R. J. Chromatogr. B. 689:1997;105.
16. Zhu P.L., Snyder L.R., Dolan J.W., Djordjevic N.M., Hill D.W., Sander L.C., Waeghe T.J. J. Chromatogr. A. 756:1996;21.
17. Molnar I., Snyder L.R., Dolan J.W. LC·GC Int. 11:1998;374.
18. Hancock W., Chloupek R.C., Kirkland J.J., Snyder L.R. J. Chromatogr. A. 686:1994;31.
19. Chloupek R.C., Hancock W.S., Marchylo B.A., Kirkland J.J., Boyes B., Snyder L.R. J. Chromatogr. A. 686:1994;45.
20. Valkó K., Snyder L.R., Glajch J.L. J. Chromatogr. A. 656:1993;501.
21. Snyder L.R., Dolan J.W. J. Chromatogr. A. 721:1996;1.
22. Stadalius M.A., Quarry M.A., Mourey T.H., Snyder L.R. J. Chromatogr. 358:1986;17.
23. Snyder L.R., Antle P.E. LC Mag. 3:1985;98.
24. Dolan J.W., Snyder L.R., Woplcott R.G., Haber P., Baczek T., Kaliszan R. J. Chromatogr. A. 857:1999;41.