Protein phosphatases 1 and 2A maintain endothelial cells in a resting state, limiting the motility that is needed for the morphogenic process of angiogenesis

Otolaryngology - Head and Neck Surgery

Volumn 121, Issue 4, 1999, Pages 463-468

  Gabel, S ^a   Benefield, J ^a   Meisinger, J ^a   Petruzzelli, G J ^a   Young, M R I ^a  

^a HINES VA HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A;

ACTIN FILAMENT; ANGIOGENESIS; ARTICLE; CELL MIGRATION; CELL MOTILITY; CONTROLLED STUDY; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MICROTUBULE; SIGNAL TRANSDUCTION; TUMOR VASCULARIZATION;

EID: 0032857305     PISSN: 01945998     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0194-5998(99)70238-X     Document Type: Article

References (25)

1. IJ Fidler LM Ellis The implications of angiogenesis for the biology and therapy of cancer metastasis Cell 79 1994 185 188
2. LR Bernstein LA Liotta Molecular mediators of interactions with extracellular matrix components in metastasis and angiogenesis Curr Opin Oncol 6 1994 106 113
3. J Folkman The role of angiogenesis in tumor growth Semin Cancer Biol 3 1992 65 71
4. CJ Jackson CJ Knop I Giles VLA-2 mediates the interaction of collagen with endothelium during in vitro vascular tube formation Cell Biol Int 18 1994 859 867
5. J Benefield GJ Petruzzelli S Fowler Regulation of the steps of angiogenesis by human head and neck squamous cell carcinomas Invasion Metastasis 16 1996 291 301
6. JY Rao GPI Hemstreet RE Hurst Cellular F-actin levels as a marker for cellular transformation: correlation with bladder cancer risk Cancer Res 51 1991 2762 2767
7. PU Le TN Nguyen P Drolet-Savoie Increased β-actin expression in an invasive Moloney sarcoma virus–transformed MDCK cell variant concentrates to the tips of multiple pseudopodia Cancer Res 58 1998 1631 1635
8. E Pokorna PW Jordan CH O’Neill Actin cytoskeleton and motility in rat sarcoma cell populations with different metastatic potential Cell Motil Cytoskeleton 28 1994 25 33
9. TJ Huang TT Lee WC Lee Autophosphorylation-dependent protein kinase phosphorylates Ser25, Ser38, Ser65, Ser71, and Ser411 in vimentin and thereby inhibits cytoskeletal intermediate filament assembly J Protein Chem 13 1994 517 525
10. NJC Lamb A Fernandez JR Feramisco Modulation of vimentin containing intermediate filament distribution and phosphorylation in living fibroblasts by the cAMP-dependent protein kinase J Cell Biol 108 1989 2409 2422
11. DG Hardie AJ Haystead ATR Sim Use of okadaic acid to inhibit protein phosphatases in intact cells Methods Enzymol 201 1991 469 476
12. GD Maier MA Wright Y Lozano Regulation of cytoskeletal organization in tumor cells by protein phosphatases 1 and 2A Int J Cancer 61 1995 51 54
13. MR Young Protein phosphatases1 and 2A regulate tumor cell migration, invasion and cytoskeletal organization Adv Exp Med Biol 407 1997 311 318
14. MRI Young ME Young Y Lozano Activation of protein kinase A increases the in vitro invasion, migration, and adherence to reconstituted basement membrane by Lewis lung carcinoma tumor cells Invasion Metastasis 12 1992 253 263
15. EW Ades FJ Candal RA Swerlick HMEC-1: establishment of an immortalized human microvascular endothelial cell line J Invest Dermatol 99 1992 683 690
16. 2-stimulated migration of Lewis lung carcinoma clones Int J Cancer 49 1991 150 155
17. 2 with more aggressive tumor behavior Invasion Metastasis 11 1991 48 57
18. P Cohen Classification of protein-serine/threonine phosphatases: identification and quantitation in cell extracts Methods Enzymol 201 1991 389 427
19. MRI Young Y Lozano A Djordjevic Protein phosphatases limit tumor motility Int J Cancer 54 1993 1036 1041
20. J Meisinger S Patel K Vellody Protein phosphatase-2A association with microtubules and its role in restricting the invasiveness of human head and neck squamous cell carcinoma cells Cancer Lett 111 1997 87 95
21. 3 and ceramide reduce the invasion of tumor cells through extracellular matrix components by elevating protein phosphatase-2A Invasion Metastasis 16 1997 280 290
22. N Hosoya M Mitsui F Yazama Changes in the cytoskeletal structure of cultured smooth muscle cells induced by calyculin-A J Cell Sci 105 1993 883 890
23. P Kreienbuhl H Keller V Niggli Protein phosphatase inhibitors okadaic acid and calyculin A alter cell shape and F-actin distribution and inhibit stimulus-dependent increases in cytoskeletal actin of human neutrophils Blood 80 1992 2911 2919
24. W-C Lee J-S Yu S-D Yang Reversible hyperphosphorylation and reorganization of vimentin intermediate filaments by okadaic acid in 9L brain tumor cells J Cell Biochem 49 1992 378 393
25. N Shinoki M Sakon J Kambayashi Involvement of protein phosphatase-1 in cytoskeletal organization of cultured endothelial cells J Cell Biochem 59 1995 368 375