The Drosophila pumilio gene encodes two functional protein isoforms that play multiple roles in germline development, gonadogenesis, oogenesis and embryogenesis

Genetics

Volumn 153, Issue 1, 1999, Pages 235-250

  Parisi, Michael ^a   Lin, Haifan ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA;

ARTICLE; CELL PROLIFERATION; DROSOPHILA; EGG LAYING; EMBRYO DEVELOPMENT; GENE ACTIVITY; GENE FUNCTION; GENE MUTATION; GERM LINE; NONHUMAN; OOCYTE DEVELOPMENT; OPEN READING FRAME; PHENOTYPE; PRIMORDIAL GERM CELL; PRIORITY JOURNAL; SEXUAL DEVELOPMENT; TRANSGENE;

ANIMALS; CELL DIVISION; DROSOPHILA; DROSOPHILA PROTEINS; EXTRACHROMOSOMAL INHERITANCE; FEMALE; GENE DOSAGE; GENES, INSECT; GENETIC COMPLEMENTATION TEST; GERM CELLS; INSECT PROTEINS; MOLECULAR WEIGHT; MUTATION; OOGENESIS; OPEN READING FRAMES; OVARY; OVIPOSITION; PROTEIN ISOFORMS; STEM CELLS; TRANSGENES;

EID: 0032857210     PISSN: 00166731     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (47)

1. BARKER, D. D., C. WANG, J. MOORE, L. K. DICKINSON and R. LEHMANN, 1992 pumilio is essential for function but not for distribution of the Drosophila abdominal determinant nanos. Genes Dev. 6: 2312-2326.
2. BHAT, K. M., and P. SCHEDL, 1997 Establishment of stem cell identity in the Drosophila germline. Dev. Dyn. 210: 371-382.
3. CHOU, T. B., and N. PERRIMON, 1992 Use of a yeast site-specific recombinase to produce female: germline chimeras in Drosophila. Genetics 131: 643-653.
4. COX, D. N., A. CHAO, J. BAKER, L. CHANG and H. LIN, 1998 A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self renewal. Genes Dev. 12: 3715-3727.
5. DENG, W., and H. LIN, 1997 Spectrosomes and fusomes anchor mitotic spindles during asymmetric germ cell divisions and facilitate the formation of a polarized microtubule array for oocyte specification in Drosophila. Dev. Biol. 189: 79-94.
6. FORBES, A., and R. LEHMANN, 1998 nanos and pumilio have critical roles in the development and function of Drosophila germline stem cells. Development 125: 679-690.
7. GELBART, W. M., M. CROSBY, B. MATHEWS, W. P. RINDONE, J. CHILLEMI et al., 1997 FlyBase: a Drosophila database. The FlyBase consortium. Nucleic Acids Res. 25: 63-66.
8. GODT, D., and F. A. LASKI, 1995 Mechanisms of cell rearrangement and cell recruitment in Drosophila ovary morphogenesis and the requirement of bric a brac. Development 121: 173-187.
9. HAY, B., L. Y. JAN and Y. N. JAN, 1990 Localization of vasa, a component of Drosophila polar granules, in maternal-effect mutants that alter embryonic anteroposterior polarity. Development 109: 425-433.
10. HOROWITZ, H., and C. A. BERG, 1995 Aberrant splicing and transcription termination caused by P-element insertion into the intron of a Drosophila gene. Genetics 139: 327-335.
11. HULSKAMP, M., C. SCHRODER, C. PFEIFLE, H. JACKLE and D. TAUTZ, 1989 Posterior segmentation of the Drosophila embryo in the absence of a maternal posterior organizer gene. Nature 338: 629-632.
12. IRISH, V., R. LEHMANN and M. AKAM, 1989 The Drosophila posterior-group gene nanos functions by repressing hunchback activity. Nature 338: 646-648.
13. JAGLARZ, M. K., and K. R. HOWARD, 1994 Primordial germ cell migration in Drosophila melanogaster is controlled by somatic tissue. Development 120: 83-89.
14. KING, R. C., 1970 Ovarian Development in Drosophila melanogaster. Academic Press, New York.
15. KING, F. J., and H. LIN, 1999 Somatic signaling mediated by fs(1)Yb is essential for germline stem cell maintenance during Drosophila oogenesis. Development 126: 1833-1844.
16. LEHMANN, R., and C. NÜSSLEIN-VOLHARD, 1987 Involvement of the pumilio in the transport of an abdominal signal in the Drosophila embryo. Nature 329: 167-170.
17. LIN, H., 1998 The self-renewing mechanism of stem cells in the germline. Curr. Opin. Cell Biol. 10: 687-693.
18. LIN, H., and A. SPRADLING, 1993 Germline stem cell division and egg chamber development in transplanted Drosophila germaria. Dev. Biol. 159: 140-152.
19. LIN, H., and A. C. SPRADLING, 1997 A novel group of pumilio mutations affects the asymmetric division of germline stem cells in the Drosophila ovary. Development 124: 2463-2476.
20. LIN, H., L. YUE and A. S. SPRADLING, 1994 The Drosophila fusome, a germline-specific organelle, contains membrane skeletal proteins and functions in cyst formation. Development 120: 947-956.
21. LINDSLEY, D. L., and G. ZIMM, 1992 The Genome of Drosophila melanogaster. Academic Press, New York.
22. MACDONALD, P. M., 1992 The Drosophila pumilio gene: an unusually long transcription unit and an unusual protein. Development 114: 221-232.
23. MAHOWALD, A. P., and M. P. KAMBYSELLIS, 1980 Oogenesis, pp. 141-224 in Genetics and Biology of Drosophila, edited by M. ASHBURNER and T. R. F. WRIGHT. Academic Press, London.
24. MANSEAU, L., and T. SCHUPBACH, 1989 The egg came first, of course! Trends Genet. 5: 400-405.
25. MLODZIK, M., and Y. HIROMI 1992 The enhancer trap method in Drosophila: its application to neurobiology, pp. 397-414 in Gene Expression in Neural Tissues, Methods in Neuroscience, Vol. 9, edited by P. M. CONN. Academic Press, Orlando, FL.
26. MOORE, L. A., H. T. BROIHIER, M. VAN DOREN, L. B. LUNSFORD and R. LEHMANN, 1998 Identification of genes controlling germ cell migration and embryonic gonad formation in Drosophila. Development 125: 667-678.
27. MURATA, Y., and R. P. WHARTON, 1995 Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in Drosophila embryos. Cell 80: 747-756.
28. NAKAMURA A., R. AMIKURA, M. MUKAI, S. KOBAYASHI and P. LASKO, 1996 Requirement for a noncoding RNA in Drosophila polar granules for germ cell establishment. Science 274: 2075-2079.
29. NÜSSLEIN-VOLHARD, C., H. G. FROHNHOFER and R. LEHMANN, 1987 Determination of anterior polarity in Drosophila. Science 238: 1675-1681.
30. RORTH, P., 1996 A modular misexpression screen in Drosophila detecting tissue-specific phenotypes. Proc. Natl. Acad. Sci. USA 93: 12418-12422.
31. SAMBROOK, J., E. F. FRITSCH and T. MANIATIS, 1989 Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
32. SCHUPBACH, T., E. WIESCHAUS and R. NOTHIGER, 1978 A study of the female germ line in mosaics of Drosophila. Wilhelm Roux's Arch. Dev. Biol. 184: 41-56.
33. SCHUPBACH, T., and S. ROTH, 1994 Dorsoventral patterning in Drosophila oogenesis. Curr. Opin. Genet. Dev. 4: 502-507.
34. STELLER, H., and V. PIRROTTA, 1986 P transposons controlled by the heat shock promoter. Mol. Cell. Biol. 6: 1640-1649.
35. STRUHL, G., 1989 Differing strategies for organizing anterior and posterior body patterns in Drosophila embryos. Nature 338: 741-744.
36. WARRIOR, R., 1994 Primordial germ cell migration and the assembly of the Drosophila embryonic gonad. Dev. Biol. 166: 180-194.
37. WEI, G., and A. P. MAHOWALD, 1994 The germline: familiar and newly uncovered properties. Annu. Rev. Genet. 28: 309-324.
38. WHARTON, R. P., and G. STRUHL., 1991 RNA regulatory elements mediate control of Drosophila body pattern by the posterior morphogen nanos. Cell 67: 955-967.
39. WHARTON, R. P., J. SONODA, T. LEE, M. PATTERSON and Y. MURATA, 1998 The pumilio RNA-binding domain is also a translational regulator. Mol. Cell. 1: 863-872.
40. WIESCHAUS, E., and J. SZABAD, 1979 The development and function of the female germline in Drosophila melanogaster, a cell lineage study. Dev. Biol. 68: 29-46.
41. WILLIAMSON, A., and R. LEHMANN, 1996 Germ cell development in Drosophila. Annu. Rev. Cell Dev. Biol. 12: 365-391.
42. WILSON, J. E., and P. M. MACDONALD, 1993 Formation of germ cells in Drosophila. Curr. Opin. Genet. Dev. 3: 562-565.
43. WREDEN, C., A. C. VERROTTI, J. A. SCHISA, M. E. LIEBERFARB and S. STRICKLAND, 1997 nanos and pumilio establish embryonic polarity in Drosophila by promoting posterior deadenylation of hunchback mRNA. Development 124: 3015-3023.
44. ZACCAI, M., and H. D. LIPSHITZ, 1996 Differential distributions of two adducin-like protein isoforms in the Drosophila ovary and early embryo. Zygote 4: 159-166.
45. ZAMORE, P. D., J. R. WILLIAMSON and R. LEHMANN, 1997 The PUMILIO protein binds RNA through a conserved domain that defines a new class of RNA-binding proteins. RNA 3: 1421-1433.
46. ZAMORE, P. D., D. P. BARTEL, R. LEHMANN and J. R. WILLIAMSON, 1999 The PUMILIO-RNA interaction: A single RNA-binding domain monomer recognizes a bipartite target sequence. Biochemistry 38: 596-604.
47. ZHANG, N., J. ZHANG, Y. CHENG and K. HOWARD, 1996 Identification and genetic analysis of wunen, a gene guiding Drosophila melanogaster germ cell migration. Genetics 143: 1231-1241.