A study of the metabolism of apolipoprotein B100 in relation to insulin resistance in African American males

Proceedings of the Society for Experimental Biology and Medicine

Volumn 221, Issue 4, 1999, Pages 352-360

  Sumner, Anne E ^a,c   Falkner, Bonita ^a   Diffenderfer, Margaret R ^a   Barrett, P Hugh R ^b   Marsh, Julian B ^a,d  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B100; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; INTERMEDIATE DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; VERY LOW DENSITY LIPOPROTEIN;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN RESISTANCE; LIPOPROTEIN METABOLISM; MALE; NEGRO; OBESITY;

EID: 0032856521     PISSN: 00379727     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1525-1373.1999.d01-92.x     Document Type: Article

References (28)

1. Reaven GM. Role of insulin resistance and hyperinsulinemia in coronary heart disease. Metabolism 41(Suppl 1):16-19, 1992.
2. DeFronzo RA, Ferrannini E. Insulin resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care 14:173-194, 1991.
3. Falkner B, Kushner H, Tulenko T, Summer AE, Marsh JB. Insulin sensitivity, lipids, and blood pressure in young American blacks. Arterioscler Thromb Vasc Biol 15:1798-1804, 1995.
4. National Center for Health Statistics. Monthly Vital Statistics Report: Advance Report of Final Mortality Statistics. Washington, DC: Department of Health and Human Services, 38 No. 5, Publication No. (PHS) 89-1120, 1989.
5. Steiner G. Hypertriglyceridemia and carbohydrate intolerance: Interrelations and therapeutic implications. Am J Cardiol 57:27G-30G, 1986.
6. Laws A. Free fatty acids, insulin resistance, and lipoprotein metabolism. Curr Opin Lipidol 7:172-177, 1996.
7. Packard CJ, Shepherd J. Lipoprotein heterogeneity and apolipoprotein B metabolism. Arterioscler Thromb Vasc Biol 17:3542-3556, 1997.
8. -. Clin Chem 30:839-842, 1984.
9. Contois JH, McNamara JR, Lammi-Keefe CJ, Wilson PWF, Massov T, Schaefer EJ. Reference intervals for plasma apolipoprotein B determined with a standardized commercial immunoturbidimetric assay: Results from the Framingham offspring study. Clin Chem 42:515-523, 1996.
10. 15N]glycine in the measurement of apolipoprotein B synthesis in perfused rat liver. J Lipid Res 32:2019-2024, 1991.
11. Evans AJ, Wolfe BM, Strong WL, Huff MW. Reduced lipolysis of large apo E-poor very-low-density lipoprotein subfractions from type IV hypertriglyceridemic subjects in vitro and in vivo. Metabolism 42:105-115, 1993.
12. Morton RE, Evans TA. Modification of the bicinchoninic acid protein assay to eliminate lipid interference in determining lipoprotein protein content. Anal Biochem 204:332-334, 1992.
13. Maguire GF, Lee M, Connelly PW. Sodium dodecyl sulfate-glycerol polyacrylamide slab gel electrophoresis for the resolution of apolipoproteins. J Lipid Res 30:757-760, 1989.
14. Cobelli C, Toffolo G, Foster DM. Tracer-to-tracee ratio for analysis of stable isotope tracer data: Link with radioactive kinetic formalism. Am J Physiol 262:E968-E975, 1992.
15. Welty FK, Lichtenstein AH, Barrett PH, Dolnikowski GG, Ordovas JM, Schaefer EJ. Decreased production and increased catabolism of apolipoprotein B-100 in apolipoprotein B-67/B-100 heterozygotes. Arterioscler Thromb Vasc Biol 17:881-888, 1997.
16. Foster DM, Barrett PHR, Bell BM, Beltz WF, Cobelli C, Golde H, Jacquez JA, Phair RD. SAAM II: Simulation, analysis, and modeling software. BMES Bulletin 18:19-21, 1994.
17. Abbott WG, Lillioja S, Young AA, Zawadzki JK, Yki-Jarvinen H, Christin L, Howard BV. Relationships between plasma lipoprotein concentrations and insulin action in an obese hyperinsulinemic population. Diabetes 36:897-904, 1987.
18. Byrne CD, Wareham NJ, Brown DC, Clark PM, Cox LJ, Day NE, Palmer DR, Wang TW, Williams DR, Hales CN. Hypertriglyceridemia in subjects with normal and abnormal glucose tolerance: Relative contributions of insulin secretion, insulin resistance and suppression of plasma nonesterified fatty acids. Diabetologia 37:889-896, 1994.
19. Steiner G, Haynes FJ, Yoshina G, Vranic M. Hyperinsulinemia and in vivo very low density lipoprotein-triglyceride kinetics. Am J Physiol 246:E187-E192, 1982.
20. Tobey TA, Greenfield M, Kraemer F, Reaven GM. Relationship between insulin resistance, insulin secretion, very low density lipoprotein kinetics, and plasma triglyceride levels in normotriglyceridemic man. Metabolism 30:165-171, 1981.
21. Howard BV, Abbott WG, Egusa G, Taskinen MR. Coordination of very low density lipoprotein triglyceride and apolipoprotein B metabolism in humans: Effects of obesity and noninsulin-dependent diabetes mellitus. Am Heart J 113:522-526, 1987.
22. Venkatesan S, Cullen P, Pacy P, Halliday D, Scott J. Stable isotopes show a direct relation between VLDL overproduction and serum triglyceride levels and indicate metabolically and biochemically coherent basis for familial combined hyperlipidemia. Arterioscler Thromb Vasc Biol 13:1110-1118, 1993.
23. Sparks JD, Sparks CE. Insulin modulation of hepatic synthesis and secretion of apolipoprotein B by rat hepatocytes. J Biol Chem 265: 8854-8862, 1990.
24. Lewis GF, Uffelman KD, Szeto LW, Steiner G. Effects of acute hyperinsulinemia on VLDL triglyceride and VLDL apoB production in normal weight and obese individuals. Diabetes 42:833-842, 1993.
25. Lin Y, Smit MJ, Verkade HJ, Vonk RJ, Kuipers F. Differential effects of eicosapentaenoic acid on glycerolipid and apolipoprotein B metabolism in primary human hepatocytes compared to HepG2 cells and primary rat hepatocytes. Biochim Biophys Acta 1256:88-96, 1995.
26. Knudsen P, Eriksson J, Lahdenpera S, Kahri J, Groop L, Taskinen MR. Changes of lipolytic enzymes cluster with insulin resistance syndrome. Botnia Study Group. Diabetologia 38:344-350, 1995.
27. Vega GL, Clark LT, Tang A, Marcovina S, Grundy SM, Cohen JC. Hepatic lipase activity is lower in African American men than in white American men: Effects of 5′ flanking polymorphism in the hepatic lipase gene (LIPC). J Lipid Res 39:228-232, 1998.
28. Cummings MH, Watts GF, Pal C, Umpleby M, Hennessy TR, Naoumova R, Sonksen PH. Increased hepatic secretion of very-low-density lipoprotein apolipoprotein B-100 in obesity: A stable isotope study. Clin Sci 88:225-233, 1995.