Allelic loss of the NF1 gene in NF1-associated plexiform neurofibromas

Cancer Genetics and Cytogenetics

Volumn 113, Issue 1, 1999, Pages 65-69

  Kluwe, Lan ^a   Friedrich, Reinhard E ^a   Mautner, Victor F ^b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b Klinik Ochsenzoll   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; CLINICAL ARTICLE; FEMALE; GEL ELECTROPHORESIS; GENE LOSS; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; MALE; NEUROFIBROMA; NEUROFIBROMATOSIS; PRIORITY JOURNAL;

ADULT; CHILD; CHILD, PRESCHOOL; DNA MUTATIONAL ANALYSIS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EXONS; FACIAL NEOPLASMS; FEMALE; GENES, NEUROFIBROMATOSIS 1; GENES, P53; HUMANS; LEG; LOSS OF HETEROZYGOSITY; MALE; MIDDLE AGED; NEUROFIBROMA, PLEXIFORM; NEUROFIBROMATOSIS 1; ORBITAL NEOPLASMS; PERIPHERAL NERVOUS SYSTEM DISEASES;

EID: 0032856294     PISSN: 01654608     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-4608(99)00006-0     Document Type: Article

References (23)

1. Huson S.M. Recent developments in the diagnosis and management of neurofibromatosis. Arch Dis Child. 64:1989;745-749.
2. Huson S.M., Hughes R.A.C. The neurofibromatoses. a pathogenetic and clinical overview:1994;Chapman and Hall, London.
3. Marchuk D.A., Collins F.S. Molecular genetics of neurofibromatosis 1. Huson S.M., Hughes R.A.C. The neurofibromatoses. A pathogenetic and clinical overview. 1994;23-49 Chapman and Hall, London.
4. Huson S.M., Harper P.S., Compston A.S. Von Recklinghausen neurofibromatosis. A clinical and population study in south-east Wales. Brain. 111:1988;1355-1381.
5. Tonsgard J.H., Kwak S.M., Short P., Dachmann A.H. CT imaging in adults with neurofibromatosis - 1. Frequent asymptomatic plexiform lesions. Neurology. 50:1998;1755-1760.
6. Cawthon R., Weiss R., Xu G., Viskochil D., Vulver M., Stevens J., Robertson M., Dunn D., Gesteland R., O'Connell P., White R. A major segment of neurofibromatosis type 1 gene. cDNA sequence, genomic structure and point mutations Cell. 62:1990;193-201.
7. Viskochil D., Buchberg A.M., Xu G., Stevens J., Wolff R.K., Culver M., Carey J.C., Copeland N.G., Jenkins N.A., White R., O'Connel P. Deletions and translocations interrupt a cloned gene at the neurofibromatosis type 1 locus. Cell. 62:1990;187-192.
8. Wallace M.R., Marchuk D.A., Andersen L.B., Letcher R., Oden H.M., Saulino A.M., Fountain J.W., Brereton A.M., Nicholson J., Mitchell A.L., Brownstein B.H., Collins F.S. Type 1 neurofibromatosis gene. identification of a large transcript disrupted in three NF1 patients Science. 249:1990;181-186.
9. Knudson A.G. Mutation and cancer. statistical study of retinoblastoma Proc Natl Acad Sci USA. 68:1971;820-823.
10. Skuse G.R., Koschiolek B.A., Rowley P.T. Molecular genetic analysis of tumors in von Recklinghausen neurofibromatosis. loss of heterozygosity for chromosome 17 Genes Chromosom Cancer. 1:1989;36-41.
11. Legius E., Marchuk D.A., Collins F.S., Glover T.W. Somatic deletion of the neurofibromatosis type 1 gene in a neurofibromsarcoma supports a tumor suppressor gene hypothesis. Nature Genet. 3:1993;122-126.
12. Colman S.D., Williams C.A., Wallace M.R. Benign neurofibromas in type 1 neurofibromatosis (NF1) show somatic deletions of NF1 gene. Nature Genet. 11:1995;90-92.
13. Serra E., Puig S., Otero D., Gaona A., Kruyer H., Ars E., Estivill X., Lazaro C. Confirmation of a double-hit model for the NF1 gene in benign neurofibromas. Am J Hum Genet. 61:1997;512-519.
14. Sawada S., Florell S., Purandare S.M., Ota M., Stephens K., Viskochil D. Identification of NF1 mutations in both alleles of a dermal neurofibroma. Nature Genet. 14:1996;110-112.
15. Däschner K., Assum G., Eisenbarth I., Krone W., Hoffmeyer S., Wortmann S., Heymer B., Kehrer-Sawatzki H. Clonal origin of tumor cells in a plexiform neurofibroma with LOH in NF1 intron 38 and in dermal neurofibromas without LOH of the NF1 gene. Biochem Biophys Res Commun. 234:1997;346-350.
16. Rasmussen SA, Colman SD, Abernathy CR, Muir D, Wallace MR (1997): Somatic loss of the NF1 gene in plexiform neurofibromas in neurofibromatosis type 1. Presented at The Neurofibromatosis Symposium in Conjunction with The 47th Annual Meeting of The American Society of Human Genetics, Baltimore, MD, October 28, 1997.
17. Andersen L.B., Tarle S.A., Marchuk D.A., Legius E., Collins F.S. A compound nucleotide repeat in the neurofibromatosis (NF1) gene. Hum Mol Genet. 2:1993;1083.
18. Kappes S., Milde-Langosch K., Kressin P., Passlack B., Dockhorn-Dworniczak B., Röhlke P., Lönning T. p53 mutations in ovarian tumors, detected by temperature-gradient gel electrophoresis, direct sequencing and immunohistochemistry. Int J Cancer. 64:1995;52-59.
19. Wiestler O.D., Radner H. Pathology of neurofibromatosis 1 and 2. The neurofibromatoses. A pathogenetic and clinical overview. 1994;135-159 Chapman and Hall, London.
20. Rubenstein A.E. Neurofibromatosis. a review of the clinical problem Ann NY Acad Sci. 486:1986;1-13.
21. Menon A.G., Anderson K.M., Riccardi V.M., Chung R.Y., Whaley J.M., Ledbetter D.H., Kleider A., Martuza R., Gusella J.F., Seizinger B.R. Chromosome 17p deletions and p53 mutations associated with the formation of malignant neurofibrosarcomas in von Recklinghausen neurofibromatosis. Proc Natl Acad Sci USA. 87:1990;5435-5439.
22. Legius E., Dierick H., Wu R., Hall B.K., Marynen P., Cassiman J.-J., Glover T.W. TP53 mutations are frequent in malignant NF1 tumors. Genes Chromosom Cancer. 10:1994;250-255.
23. Lothe R.A., Slettan A., Saeter G., Brogger A., Borresen A.L., Nesland J.M. Alterations at chromosome 17 loci in peripheral nerve sheath tumors. J Neuropathol Exp Neurol. 54:1995;65-73.