Universal and unique features of kinesin motors: Insights from a comparison of fungal and animal conventional kinesins

Biological Chemistry

Volumn 380, Issue 7-8, 1999, Pages 915-921

  Kirchner, Jochen ^a   Woehlke, Günther ^a   Schliwa, Manfred ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cargo association; Kinesin; Molecular motors; Sequence organization

Indexed keywords

ADENOSINE TRIPHOSPHATE; KINESIN;

AMINO ACID SEQUENCE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENERGY; FUNGUS; HYDROLYSIS; MICROTUBULE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SEQUENCE HOMOLOGY; SPECIES DIFFERENCE;

ANIMALIA; FUNGI;

EID: 0032854874     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.1999.113     Document Type: Review

References (50)

1. Alonso, M.C., van Damme, J., Vandekerckhove, J., and Cross, R.A. (1998). Proteolytic mapping of kinesin/ncd-microtubule interface: nucleotide-dependent conformational changes in the loops L8 and L12. EMBO J. 17, 945-951.
2. Blocker, A., Severin, F.F., Burkhardt, J.K., Bingham, J.B., Yu, H., Olivo, J.C., Schroer, T.A., Hyman, A.A., and Griffiths, G. (1997). Molecular requirements for bi-directional movement of phagosomes along microtubules. J. Cell Biol. 137, 113-129.
3. Bloom, G.S., and Endow, S.A. (1995). Motor proteins 1: Kinesins. Protein profile 1, 1059-1116.
4. Brady, S.T. (1985). A novel brain ATPase with properties expected for the fast axonal transport motor. Nature 317, 73-75.
5. Burd, C.G., and Dreyfuss, G. (1994). Conserved structures and diversity of functions of RNA-binding proteins. Science 265, 615-621.
6. Burkhardt, J. (1996). In search of membrane receptors for microtubule-based motors - is kinectin a kinesin receptor? Trends Cell Biol. 6, 127-131.
7. Case, R.B., Pierce, D.W., Hom-Boher, N., Hart, C.L., and Vale, R.D. (1997). The directional preference of kinesin motors is specified by an element outside the catalytic motor domain. Cell 90, 1-20.
8. Desai, A., Verma, S., Mitchison, T.J., and Walczak, C.E. (1999). Kin I kinesins are microtubule-destabilizing enzymes. Cell 96, 69-78.
9. Diefenbach, R.J., Mackay, J.P., Armati, P.J., and Cunningham, A.L. (1998). The C-terminal region of the stalk domain of ubiquitous human kinesin heavy chain contains the binding site for kinesin light chain. Biochemistry 37, 16663-16670.
10. Endow, S.A., and Waligora, K.W. (1998). Determinants of kinesin motor polarity. Science 281, 1200-1202.
11. Gho, M., McDonald, K., Ganetzky, B., and Saxton, W.M. (1992). Effects of kinesin mutations on neuronal functions. Science 258, 313-316.
12. Grummt, M., Woehlke, G., Henningsen, U., Fuchs, S., Schleicher, M., and Schliwa, M. (1998). Importance of a flexible hinge near the motor domain in kinesin-driven motility. EMBO J. 17, 5536-5542.
13. Gulick, A.M., Song, H., Endow, S.A., and Rayment, I. (1998). X-ray crystal structure of the yeast Kar 3 motor domain complexed with MgATP to 2.3 Å resolution. Biochemistry 37, 1769-1776.
14. Hackney, D.D., Levitt, J.D., and Suhan, J. (1992). Kinesin undergoes a 9S to 6S conformational transition. J. Biol. Chem. 267, 8696-8701.
15. Henningsen, U., and Schliwa, M. (1997). Reversal in the direction of a movement in a molecular motor. Nature 389, 93-96.
16. Hirokawa, N., Pfister, K.K., Yorifuji, H., Wagner, M.C., Brady, S.T., and Bloom, G.S. (1989). Submolecular domains of bovine brain kinesin identified by electron microscopy and monoclonal antibody decoration. Cell 56, 867-878.
17. Hirokawa, N. (1998). Kinesin and dynein superfamily proteins and the mechanism of organelle transport. Science 279, 519-526.
18. Hurd, D.D., and Saxton, W.M. (1996). Kinesin mutations cause motor neuron disease phenotypes by disrupting fast axonal transport in Drosophila. Genetics 144, 1075-1085.
19. Kozielski, F., Sack, S., Marx, A., Thormählen, M., Schönbrunn, E., Biou, V., Thompson, A., Mandelkow, E.M., and Mandelkow, E. (1997). The crystal structure of dimeric kinesin and implications for microtubule-dependent motility. Cell 91, 985-994.
20. Kull, F.J., Sablin, E.P., Lau, R., Fletterick, R.J., and Vale, R.D. (1996). Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature 380, 550-555.
21. Kumar, J., Yu, H., and Sheetz, M.P. (1995). Kinectin, an essential anchor for kinesin-driven vesicle motility. Science 267, 1834-1837.
22. Lane, J., and Allan, V. (1998). Microtubule-based membrane movement. Biochimica et Biophysica Acta 1376, 27-55.
23. Lehmler, C., Steinberg, G., Snetselaar, K.M., Schliwa, M., Kahmann, R., and Bölker, M. (1997). Identification of a motor protein required for filamentous growth in U. maydis. EMBO J. 16, 3464-3473.
24. Lupas, A., Van Dyke, M., and Stock, J. (1991). Predicting coiled-coils from protein sequences. Science 252, 1162-1164.
25. Morii, H., Takenawa, T., Arisaka, F., and Shimizu, T. (1997). Identification of kinesin neck region as a stable α-helical coiled-coil and its thermodynamic characterization. Biochemistry 36, 1933-1942.
26. Nagakawa, T., Tanaka, Y., Matsuoka, E., Kondo, S., Okada, Y., Noda, Y., Kanai, Y., and Hirokawa, N. (1997). Identification and classification of 16 new kinesin superfamily (KIF) proteins in mouse genome. Proc. Natl. Acad. Sci. USA 94, 9654-9659.
27. Patel, N., Thierry-Mieg, D., and Mancillas, J.R. (1993). Cloning by insertional mutagenesis of a cDNA encoding C. elegans kinesin heavy chain. Proc. Natl. Acad. Sci. USA 90, 9181-9185.
28. Romberg, L., Pierce, D.W., and Vale, R.D. (1998). Role of the kinesin neck region in processive microtubule-based motility. J. Cell Biol. 140, 1407-1416.
29. Sablin, E.P., Kull, F.J., Cooke, R., Vale, R.D., and Fletterick, R.J. (1996). Crystal structure of the motor domain of the kinesin-related motor ncd. Nature 380, 555-559.
30. Sack, S., Müller, J., Marx, A., Thormählen, M., Mandelkow, E.M., Brady, S.T., and Mandelkow, E. (1997). X-ray structure of motor and neck domains from rat brain kinesin. Biochemistry 36, 16155-16165.
31. Saxton, W.M., Hicks, J., Goldstein, L.S.B., and Raff, E.C. (1991). Kinesin heavy chain is essential for viability and neuromuscular functions in Drosophila, but mutants show no defect in mitosis. Cell 64, 1093-1102.
32. Schnapp, B.J., Reese, T.S., and Bechtold, R. (1992). Kinesin is bound with high affinity to squid axon organelles that move to the plus-end of microtubules. J. Cell Biol. 119, 389-399.
33. Scholey, J.M., Porter, M.E., Grissom, P.M., and McIntosh, J.R. (1985). Identification of kinesin in sea urchin eggs, and evidence for its localization in the mitotic spindle. Nature 318, 483-486.
34. Schroer, T.A., Schnapp, B.J., Reese, T.S., and Sheetz, M.P. (1988). The role of kinesin and other soluble factors in organelle movement along microtubules. J. Cell Biol. 107, 1785-1792.
35. Seiler, S., Nargang, F., Steinberg, G., and Schliwa, M. (1997). Kinesin is essential for cell morphogenesis and polarized secretion in N. crassa. EMBO J. 16, 3025-3034.
36. Sharp, D.J., McDonald, K.L. Brown, H.M., Matthies, H.J., Walczak, C., Vale, R.D., Mitchison, T.J., and Scholey, J.M. (1999). The bipolar kinesin, KLP61F, cross-links microtubules within interpolar bundles of Drosophila embryonic mitotic spindles. J. Cell Biol. 144, 125-138.
37. Sheetz, M.P. (1996). Microtubule motor complexes moving membranous organelles. Cell Struc. Funct. 21, 369-373.
38. Sosa, H., Dias, D.P., Hoenger, A., Whittaker, M., Wilson-Kubalek, E., Sablin, E., Fletterick, R.J., Vale, R.D., and Milligan, R.A. (1997). A model for the microtubule-Ncd motor protein complex obtained by cryo-electron microscopy and image analysis. Cell 90, 217-224.
39. Steinberg, G. (1998). Organelle transport and molecular motors in fungi. Fungal Genet. Biol. 24, 161-177.
40. Tanaka, Y., Kanai, Y., Okada, Y., Nonaka, S., Takeda, S., Harada, A., and Hirokawa, N. (1998). Targeted disruption of mouse conventional kinesin heavy chain, kif5b, results in abnormal perinuclear clustering of mitochondria. Cell 93, 1147-1158.
41. Tripet, B., Vale, R.D., and Hodges, R.S. (1997). Demonstration of coiled-coil interactions within the kinesin neck region using synthetic peptides. J. Biol. Chem. 272, 8946-8956.
42. Vale, R.D. (1996). Switches, latches and amplifiers: common themes of G proteins and molecular motors. J. Cell Biol. 135, 291-302.
43. Vale, R.D., and Fletterick, R. (1997). The design plan of kinesin motors. Annu. Rev. Cell Dev. Biol. 13, 745-777.
44. Vale, R.D., Reese, T.S., and Sheetz, M.P. (1985). Identification of a novel force-generating protein, kinesin, involved in microtubule based motility. Cell 42, 39-50.
45. Verhey, K.J., Lizotte, D.L., Abramson, T., Barenboim, L., Schnapp, B.J., and Rapoport, T.A. (1998). Light chain-dependent regulation of kinesin's interaction with microtubules. J. Cell Biol. 143, 1053-1066.
46. Woehlke, G., Ruby, A.K., Hart, C.L., Ly, B., Hom-Booher, N., and Vale, R.D. (1997). Microtubule interaction site of the kinesin motor. Cell 90, 207-216.
47. Wu, Q., Sandrock, T.M., Turgeon, B.G., Yoder, O.C., Wirsel, S.G., and Aist, J.R. (1998). A fungal kinesin required for organelle motility, hyphal growth and morphogenesis. Mol. Biol. Cell 9, 89-101.
48. Xia, C., Rahman, A., Yang, Z., and Goldstein, L.S.B. (1998). Chromosomal localization reveals three kinesin heavy chain genes in mouse. Genomics 52, 209-213.
49. Yang, J.T., Saxton, W.M., Stewart, R.J., Raff, E.C., and Goldstein, L.S.B. (1990). Evidence that the head of kinesin is sufficient for force generation and motility in vitro. Science 249, 42-47.
50. Yu, H., Nicchitta, C.V., Kumar, J., Becker, M., Toyoshima, I., and Sheetz, M.P. (1995). Characterization of kinectin, a kinesin-binding protein: primary sequence and N-terminal topogenic signal analysis. Mol. Biol. Cell 6, 171-183.