Biochemical analysis of myelin lipids and proteins in a model of methyl donor pathway deficit: Effect of S-adenosylmethionine

Experimental Neurology

Volumn 159, Issue 1, 1999, Pages 258-266

  Bianchi, Roberto ^a   Calzi, Federico ^a   Savaresi, Sara ^a   Sciarretta Birolo, Roberto ^a   Bellasio, Raffaele ^a   Tsankova, Virginia ^b   Tacconi, Maria Teresa ^a  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF SOFIA   (Bulgaria)

Author keywords

Brain; Cycloleucine; Hypomyelination; Myelin lipid; Myelin protein; Rat; Sciatic nerve

Indexed keywords

CELL PROTEIN; CYCLOLEUCINE; METHIONINE; METHIONINE ADENOSYLTRANSFERASE; MYELIN; MYELIN BASIC PROTEIN; PHOSPHOLIPID; S ADENOSYLMETHIONINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN WEIGHT; CONTROLLED STUDY; ENZYME ACTIVITY; LIPID ANALYSIS; MYELINATION; NERVOUS SYSTEM DEVELOPMENT; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RAT; SCIATIC NERVE;

EID: 0032853672     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1999.7132     Document Type: Article

References (62)

1. Allen R. H., Stabler S. P., Savage D. G., Lindebaum J. Metabolic abnormalities in cobalamine (vitamin B12) and folate deficiency. FASEB J. 7:1993;1344-1353.
2. Alvarez L., Corrales F., Martin-Duce A., Mato J. M. Characterization of a full-length cDNA encoding human liver S-adenosylmethionine synthetase: Tissue-specific gene expression and mRNA levels in hepatopathies. Biochem. J. 293:1993;481-486.
3. Barbarese E., Carson J. H., Braun P. E. Accumulation of the four myelin basic proteins in mouse brain during development. J. Neurochem. 31:1978;779-782.
4. Blusztajn J. K., Zeisel S. H., Wurtman R. J. Synthesis of lecithin (phosphatidylcholine) from phosphatidylethanolamine in bovine brain. Brain Res. 179:1979;319-327.
5. Bottiglieri T., Hyland K., Reynolds E. H. The clinical potential of ademethionine (S-adenosylmethionine) in neurological disorders. Drugs. 48:1994;137-152.
6. Brostoff S., Eylar E. H. Localization of methylated arginine in the A1 protein from myelin. Proc. Natl. Acad. Sci. USA. 68:1971;765-769.
7. Coetzee T., Fujita N., Dupree J., Shi R., Blight A., Suzuki K., Suzuki K., Popko B. Myelination in the absence of galactocerebroside and sulfatide: Normal structure with abnormal function and regional instability. Cell. 86:1996;209-219.
8. Coetzee T., Suzuki K., Popko B. New perspectives on the function of myelin galactolipids. Trends Neurosci. 21:1998;126-130.
9. Castagna A., Le Grazie C., Accordini A., Giulidori P., Cavalli G., Bottiglieri T., Lazzarin A. Cerebrospinal fluid S-adenosylmethionine (SAMe) and glutathione concentrations in HIV infection: Effect of parenteral treatment with SAMe. Neurology. 45:1995;1678-1683.
10. Chamberlin M. E., Ubagai T., Mudd S. H., Wilson W. G., Leonard J. V., Chou J. Y. Demyelination of the brain is associated with methionine adenosyltransferase I/III deficiency. J. Clin. Invest. 98:1996;1021-1027.
11. Chanderkar L. P., Paik W. K., Kim S. Studies on myelin-basic-protein methylation during mouse brain development. Biochem. J. 240:1986;471-479.
12. Chiang P. K., Cantoni G. L. Activation of methionine for transmethylation: Purification of the S-adenosylmethionine synthetase of bakers' yeast and its separation into two forms. J. Biol. Chem. 252:1977;4506-4513.
13. Chiang P. K., Gordon R. K., Tal J., Zeng G. C., Doctor B. P., Pardhasaradhi K., Mc Cann P. P. S-Adenosylmethionine and methylation. FASEB J. 10:1996;471-480.
14. Campagnoni A. T. Molecular biology of myelin proteins from the central nervous system. J. Neurochem. 51:1988;1-14.
15. Campagnoni C. W., Carey G. D., Campagnoni A. T. Synthesis of myelin basic proteins in the developing mouse brain. Arch. Biochem. Biophys. 190:1978;118-125.
16. Crang A. J., Jacobson W. The relationship of myelin basic protein (arginine) methyltransferase to myelination in mouse spinal cord. J. Neurochem. 39:1982;244-247.
17. Crews F. T., Hirata F., Axelrod J. Identification and properties of methyltransferases that synthesize phosphatidylcholine in rat brain synaptosomes. J. Neurochem. 34:1980;1491-1498.
18. Dinn J. J., Weir D. G., McCann S., Reed B., Wilson P., Scott J. M. Methyl group deficiency in nerve tissue: A hypothesis to explain the lesion of subacute combined degeneration. Ir. J. Med. Sci. 149:1980;1-4.
19. Edmond J., Higa T. A., Korsak R. A., Bergner E. A., Lee W.-N. P. Fatty acid transport and utilisation for the developing brain. J. Neurochem. 70:1998;1227-1234.
20. Edwards R. P., Lee C.-C., Duchen L. W. The evolution of an experimental distal motor axonopathy: Physiological studies of changes in neuromuscular transmission caused by cycloleucine, an inhibitor of methionine adenosyltransferase. Brain. 117:1994;959-974.
21. Fairbanks G., Steck T. L., Wallach D. F. Electrophoretic analysis of the major polypeptides of the human erythrocyte membrane. Biochemistry. 10:1971;2606-2617.
22. Finkelstein J. D. Methionine metabolism in mammals. J. Nutr. Biochem. 1:1990;228-237.
23. Folch J., Lees M., Sloane-Stanley G. H. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226:1957;497-509.
24. Gandy G., Jacobson W., Sidman R. Inhibition of a transmethylation reaction in the central nervous system - An experimental model for subacute combined degeneration of the cord. J. Physiol. 233:1973;1P-3P.
25. Gaull G. E., Tallan H. H. Methionine adenosyltransferase deficiency: New enzymatic defect associated with hypermethioninemie. Science. 186:1974;59-60.
26. Gaull G. E., Tallan H. H., Lonsdale D., Przyrembel H., Schaffner F., von Bassewitz D. B. Hypermethioninemie associated with methionine adenosyltransferase deficiency: Clinical, morphological and biochemical observations on four patients. J. Pediatr. 98:1981;734-741.
27. Ghosh S. K., Rawal N., Syed S. K., Paik W. K., Kim S. Enzymic methylation of myelin basic protein in myelin. Biochem. J. 275:1991;381-387.
28. Gout J. P., Serre J. C., Dieterlen M., Antener I., Frappat P., Bost M., Beaudoing A. Une nouvelle cause d'hypermethioninemie de l'enfant: Le deficit en S-adenosyl-methionine-synthetase. Arch. Fr. Pediatr. 34:1977;416-423.
29. Griffiths I. R. Myelin mutants: Model systems for the study of normal and abnormal myelination. BioEssays. 18:1996;789-797.
30. Hyland K., Smith I., Bottiglieri T., Perry J., Wendel U., Clayton P. T., Leonard J. V. Demyelination and decreased S-adenosylmethionine in 5,10-methylenetetrahydrofolate reductase deficiency. Neurology. 38:1988;459-462.
31. Jacobson W., Gandy G., Sidman R. L. Experimental subacute combined degeneration of the cord in mice. J. Pathol. 109:1973;13-14.
32. Kim S., Tuck M., Kim M., Campagnoni A. T., Paik W. K. Studies on myelin basic protein-specific protein methylase I in various dysmyelinating mutant mice. Biochem. Biophys. Res. Commun. 123:1984;468-474.
33. Kotb M., Geller A. M. Methionine adenosyltransferase: Structure and function. Pharmacol. Ther. 59:1993;125-143.
34. Kirschner D. A., Ganser A. L. Compact myelin exists in the absence of basic protein in the shiverer mutant mouse. Nature. 283:1980;207-210.
35. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 277:1970;680-685.
36. Lee C.-C., Surtees R., Duchen L. W. Distal motor axonopathy and central nervous system myelin vacuolation caused by cycloleucine, an inhibitor of methionine adenosyltransferase. Brain. 115:1992;935-955.
37. LeKim D., Betzing H., Stoffel W. Studies in vivo and in vitro on the methylation of phosphatidyl-N,N-dimethylethanolamine to phosphatidylcholine in rat liver. Hoppe-Seylers Z. Physiol. Chem. 354:1973;437-444.
38. Lombardini J. B., Coulter A. W., Talalay P. Analogues of methionine as substrates and inhibitors of the methionine adenosyltransferase reaction: Deductions concerning the conformation of methionine. Mol. Pharmacol. 6:1970;481-499.
39. Lombardini J. B., Talalay P. Effects of inhibitors of adenosine triphosphate:l-methionine S-adenosyltransferase on levels of S-adenosyl-l-methionine and l-methionine in normal and malignant mammalian tissues. Mol. Pharmacol. 9:1973;542-560.
40. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:1951;265-275.
41. Magret V., Elkhalil L., Nazih-Sanderson F., Martin F., Bourre J. M., Fruchart J. C., Delbart C. Entry of polyunsaturated fatty acids into the brain: Evidence that high-density lipoprotein-induced methylation of phosphatidylethanolamine and phospholipase A2 are involved. Biochem. J. 316:1996;805-811.
42. Mato J. M., Alvarez L., Ortiz P., Pajares M. A. S-Adenosylmethionine synthesis: Molecular mechanisms and clinical implications. Pharmacol. Ther. 73:1997;265-280.
43. Metz J. Cobalamine deficiency and the pathogenesis of nervous system disease. Annu. Rev. Nutr. 12:1992;59-79.
44. Morell P., Toews A. D. Schwann cells as targets for neurotoxicants. Neurotoxicology. 17:1996;685-696.
45. Morell P., Quarles R. H., Norton W. T. Myelin formation, structure, and biochemistry. Siegel G. J., Agranoff B. W., Albers R. W., Molinoff P. B. Basic Neurochemistry: Molecular, Cellular and Medical Aspects. 1994;117-143 Raven Press, New York.
46. Nixon R. A. Neurotoxicity of a non-metabolizable amino acid, 1-aminocyclopentane-1-carboxylic acid: regional protein levels and lipid composition of nervous tissue. J. Neurochem. 27:1976;237-244.
47. Norton W. T., Poduslo S. E. Myelination in rat brain: Changes in myelin composition during brain maturation. J. Neurochem. 21:1973;759-773.
48. Palma A. E., Owh P., Fredric C., Readhead C., Moscarello M. A. Characterization of myelin basic proteins charge microheterogeneity in developing mouse brain and in the transgenic shiverer mutant. J. Neurochem. 69:1997;1753-1762.
49. Park I. K., Paik W. K. The occurrence and analysis of methylated amino acids. Paik W. K., Kim S. Protein Methylation. 1990;1-22 CRC Press, Boca Raton.
50. Ramsey R. B., Fischer V. W. Effect of 1-aminocyclopentane-1-carboxylic acid (cycloleucine) on developing rat central nervous system phospholipids. J. Neurochem. 30:1978;447-457.
51. Rawal N., Paik W. K., Kim S. An enzyme-linked immunosorbent assay for myelin basic protein-specific protein methylase I. J. Neurosci. Methods. 37:1991;133-140.
52. Salvati S., Attorri L., Confaloni A., Di Biase A. Lipid changes in central nervous system membranes in experimental allergic encephalomyelitis (EAE). Neurochem. Res. 15:1990;1051-1053.
53. Small D. H., Carnegie P. R., Anderson R. McD. Cycloleucine-induced vacuolation of myelin is associated with inhibition of protein methylation. Neurosci. Lett. 21:1981;287-292.
54. Surtees R., Leonard J., Austin S. Association of demyelination with deficiency of cerebrospinal-fluid S-adenosylmethionine in inborn errors of methyl-transfer pathway. Lancet. 338:1991;1550-1554.
55. Svanborg A., Svennerholm U. Plasma total lipids, cholesterol, triglycerides, phospholipids and free fatty acids in a healthy Scandinavian population. Acta Med. Scand. 169:1961;43-49.
56. Tacconi M. T., Wurtman R. J. Rat brain phosphatidyl-N,N-dimethylethanolamine is rich in polyunsaturated fatty acids. J. Neurochem. 45:1985;805-809.
57. Tacconi M. T., Wurtman R. J. Phosphatidylcholine produced in rat synaptosomes by N-methylation is enriched in polyunsaturated fatty acids. Proc. Natl. Acad. Sci. USA. 82:1985;4828-4831.
58. Tsvetnitsky V., Auchi L., Nicolau A., Gibbons W. A. Characterization of phospholipid methylation in rat brain myelin. Biochem. J. 307:1995;239-244.
59. Ubagai T., Lei K. J., Huang S., Mudd S. H., Levy H. L., Chou J. Y. Molecular mechanisms of an inborn error of methionine pathway: Methionine adenosyltransferase deficiency. J. Clin. Invest. 96:1995;1943-1947.
60. Wagner J., Claverie N., Danzin C. A rapid high-performance liquid chromatographic procedure for the simultaneous determination of methionine, ethionine, S-adenosylmethionine, S-adenosylethionine and the natural polyamines in rat tissues. Anal. Biochem. 140:1984;108-116.
61. Wolfgram F. A new proteolipid fraction of nervous system. I. Isolation and amino acid analyses. J. Neurochem. 13:1966;461-470.
62. Yamamoto A., Rouser G. Spectrophotometric determination of molar amounts of glycosphingolipids and ceramides by hydrolysis and reaction with trinitrobenzenesulfonic acid. Lipids. 5:1970;442-444.