Comparison of 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine with gemcitabine in its antitumor activity

Cancer Letters

Volumn 144, Issue 2, 1999, Pages 177-182

  Miura, Shinji ^a   Yoshimura, Yuichi ^a   Endo, Mikari ^a   Satoh, Hiroshi ^a   Machida, Haruhiko ^a   Sasaki, Takuma ^b  

^a YAMASA CORPORATION   (Japan)

^b KANAZAWA UNIVERSITY   (Japan)

Author keywords

1 (2 Deoxy 2 fluoro 4 thio D arabinofuranosyl)cytosine; Colon carcinoma; Gastric carcinoma; Gemcitabine; Nucleos ide; Oral administration

Indexed keywords

1 (2 DEOXY 2 FLUORO 4 THIO BETA DEXTRO ARABINOFURANOSYL)CYTOSINE; CYTARABINE; GEMCITABINE; NUCLEOSIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG INTERMITTENT THERAPY; DRUG POTENCY; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN CELL; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; NUDE MOUSE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; TUMOR XENOGRAFT;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; COLONIC NEOPLASMS; CYTARABINE; DEOXYCYTIDINE; DRUG SCREENING ASSAYS, ANTITUMOR; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; NEOPLASM TRANSPLANTATION; STOMACH NEOPLASMS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0032853253     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(99)00221-9     Document Type: Article

References (16)

1. Hertel L.W., Boder G.B., Kroin J.S., Rinzel S.M., Poore G.A., Todd G.C., Grindey G.B. Evaluation of the antitumor activity of gemcitabine (2′,2′-difluoro-2′-deoxycytidine), Cancer Res. 50:1990;4417-4422.
2. Lund B., Kristjansen P.E.G., Hansen H.H. Clinical and preclinical activity of 2′,2′-difluorodeoxycytidine (gemcitabine), Cancer Treat. Rev. 19:1993;45-55.
3. Yamagami K., Fujii A., Arita M., Okumoto T., Sakata S., Matsuda A., Ueda T., Sasaki T. Antitumor activity of 2′-deoxy-2′-methylidenecytidine, a new 2′-deoxycytidine derivative. Cancer Res. 51:1991;2319-2323.
4. Tanaka M., Matsuda A., Terao T., Sasaki T. Antitumor activity of a novel nucleoside. 2′-C-cyano-2′-deoxy-1-β-D-arabinofuranosylcytosine (CNDAC) against murine and human tumors, Cancer Lett. 64:1992;67-74.
5. Tabata S., Tanaka M., Matsuda A., Fukushima M., Sasaki T. Antitumor effect of a novel multifunctional antitumor nucleoside. 3′-ethynylcytidine, on human cancers, Oncol. Rep. 3:1996;1029-1034.
6. Siu L.L., Attardo G., Izbicka E., Lawrence R., Cerna C., Gomez L., Davidson K., Finkle C., Marsolais C., Rowinsky E.K., Von Hoff D.D. Activity of (-)-2′-deoxy-3′-oxacytidine (BCH-4556) against human tumor colony-forming units. Ann. Oncol. 9:1998;885-891.
7. Kaye S.B. New antimetabolites in cancer chemotherapy and their clinical impact. Br. J. Cancer 78 (Suppl. 3:1998;1-7.
8. Yoshimura Y., Kitano K., Sakata S., Miura S., Ashida N. Machida. H., Matsuda, A. Synthesis of 2′-deoxy-2′-fluoro-4′-arabinonucleosides as potential antitumor and antiviral agents from D-glucose, Nucleic Acids Symp. Ser. 35:1996;15-16.
9. Yoshimura Y., Kitano K., Yamada K., Satoh H., Watanabe M., Miura S., Sakata S., Sasaki T., Matsuda A. A novel synthesis of 2′-modified 2′-deoxy-4′-thiocytidines from D-glucose. J. Org. Chem. 62:1997;3140-3152.
10. Miura S., Yoshimura Y., Endo M., Machida H., Matsuda A., Tanaka M., Sasaki T. Antitumor activity of a novel orally effective nucleoside. 1-(2-deoxy-2-fluoro-4-thio-β-D-arabinofuranosyl)cytosine, Cancer Lett. 129:1998;103-110.
11. Hertel L.W., Kroin J.S., Misner J.W., Tustin J.M. Synthesis of 2-deoxy-2,2-difluoro-D-ribose and 2-deoxy-2,2-difluoro-D-ribofuranosyl nucleosides, J. Org. Chem. 53:1988;2406-2409.
12. Mossman T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 65:1983;55-63.
13. Ovejera A.A., Houchens D.P., Barker A.D. Chemotherapy of human tumor xenografts in genetically athymic mice. Ann. Clin. Lab. Sci. 8:1978;50-56.
14. Heinemann V., Hertel L.W., Grindey G.B., Plunkett W. Comparison of the cellular pharmakokinetics and toxicity of 2′,2′-difluorodeoxycytidine and 1-β-D-arabinofuranosylcytosine, Cancer Res. 48:1988;4024-4031.
15. Baker C.H., Banzon J., Bollinger J.M., Sttube J., Samano V., Robins M.J., Lippert B., Jarvi E., Resvick R. 2′-Deoxy-2′-methylidenecytidine and 2′-deoxy-2′ 2′-difluorocytidine 5′-diphosphates: potent mechanism-based inhibitors of ribonucleotide reductase, J. Med. Chem. 34:1991;1879-1884.
16. Huang P., Chubb S., Hertel L.W., Grindey G.B., Plunkett W. Action of 2′,2′-difluorodeoxycytidine on DNA synthesis, Cancer Res. 51:1991;6110-6117.