High prevalence of TT virus (TTV) infection in patients on maintenance hemodialysis: Frequent mixed infections with different genotypes and lack of evidence of associated liver disease

Journal of Medical Virology

Volumn 59, Issue 3, 1999, Pages 313-317

  Forns, Xavier ^a   Hegerich, Patricia ^a   Darnell, Alejandro ^b   Emerson, Suzanne U ^a   Purcell, Robert H ^a   Bukh, Jens ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Blood transfusion; Hepatitis; Nosocomial transmission

Indexed keywords

ADULT; ARTICLE; BLOOD TRANSFUSION; FEMALE; GENOTYPE; HEMODIALYSIS; HEPATITIS; HEPATITIS NON A NON B; HOSPITAL INFECTION; HUMAN; LIVER DISEASE; MAINTENANCE THERAPY; MAJOR CLINICAL STUDY; MALE; MIXED INFECTION; PREVALENCE; VIRUS INFECTION; VIRUS TRANSMISSION;

ADULT; AGED; BASE SEQUENCE; BLOOD TRANSFUSION; COHORT STUDIES; CROSS INFECTION; DISEASE TRANSMISSION, HORIZONTAL; DNA VIRUS INFECTIONS; DNA, VIRAL; HEPATITIS, VIRAL, HUMAN; HUMANS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PHYLOGENY; POLYMERASE CHAIN REACTION; PREVALENCE; RENAL DIALYSIS; RISK FACTORS; SPAIN;

DNA VIRUSES; HEPATITIS B VIRUS; HEPATITIS C VIRUS; NON-A, NON-B HEPATITIS VIRUS; TT VIRUS;

EID: 0032852557     PISSN: 01466615     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9071(199911)59:3<313::AID-JMV9>3.0.CO;2-B     Document Type: Article

References (18)

1. Charlton M, Adjei P, Poterucha J, Zein N, Moore B, Therneau T, Krom R, Wiesner R. 1998. TT-virus infection in North American blood donors, patients with fulminant hepatic failure, and cryptogenic cirrhosis. Hepatology 28:839-842.
2. Forns X, Fernández-Llama P, Costa J, Lopez-Labrador FX, Ampurdanes S, Olmedo E, Saiz JC, Guilera M, Lopez-Pedret J, Sanchez-Tapias JM, Darnell A, Jimenez de Anta MT, Ordinas A, Rodes J. 1997a. Hepatitis G virus infection in a hemodialysis unit: prevalence and clinical implications. Nephrol Dial Transplant 12:956-960.
3. Forns X, Fernández-Llama P, Pons M, Costa J, Ampurdanes S, Lopez-Labrador FX, Olmedo E, Lopez-Pedret J, Darnell A, Revert Ll, Sanchez-Tapias JM, Rodes J. 1997b. Incidence and risk factors of hepatitis C virus infection in a haemodialysis unit. Nephrol Dial Transplant 12:736-740.
4. Forns X, Tan D, Alter HJ, Purcell RH, Bukh J. 1997c. Evaluation of commercially available and in-house reverse transcription-PCR for detection of hepatitis G virus or GB virus C. J Clin Microbiol 35:2698-2702.
5. Giménez-Barcons M, Forns X, Ampurdanès S, Guilera M, Soler M, Soguero C, Sanchez A, Mas A, Bruix J, Sanchez-Tapias JM, Rodes J, Saiz JC. 1999. Infection with a novel human DNA virus (TTV) has no pathogenic significance in patients with liver diseases. J Hepatol 30:1028-1034.
6. Höhne M, Berg T, Müller AR, Schreier E. 1998. Detection of sequences of TT virus, a novel DNA virus, in German patients. J Gen Virol 79:2761-2764.
7. Mushahwar IK, Erker JC, Muerhoff AS, Leary TP, Simons JN, Birkenmeyer LG, Chalmers ML, Pilot-Matias TJ, Desai SM. 1999. Molecular and biophysical characterization of TT virus: evidence for a new virus family infecting humans. Proc Natl Acad Sci USA 96:3177-3182.
8. Naoumov NV, Petrova EP, Thomas MG, Williams R. 1998. Presence of a newly described human DNA virus (TTV) in patients with liver disease. Lancet 352:195-197.
9. Nishizawa T, Okamoto H, Konishi K, Yoshizawa H, Miyakawa Y, Mayumi M. 1997. A novel DNA virus (TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology. Biochem Biophys Res Commun 241:92-97.
10. Okamoto H, Nishizawa T, Kato N, Ukita M, Ikeda H, Iizuka H, Miyakawa Y, Mayumi M. 1998a. Molecular cloning and characterization of a novel DNA virus (TTV) associated with posttransfusion hepatitis of unknown etiology. Hepatol Res 10:1-16.
11. Okamoto H, Akahane Y, Ukita M, Fukuda M, Tsuda F, Miyakawa Y, Mayumi M. 1998b. Fecal excretion of a nonenveloped DNA virus (TTV) associated with posttransfusion non-A-G hepatitis. J Med Virol 56:128-132.
12. Page RDM. 1996. TREEVIEW: an application to display phylogenetic trees on personal computers. Comput Appl Biosci 12:357-358.
13. Prescott LE, Simmonds P. 1998. Global distribution of transfusion-transmitted virus. N Engl J Med 339:776-777.
14. Simmonds P, Davidson F, Lycett C, Prescott LE, MacDonald DM, Ellender J, Yap PL, Ludlam CA, Haydon GH, Gillion J, Jarvis LM. 1998. Detection of a novel DNA virus (TTV) in blood donors and blood products. Lancet 352:191-195.
15. Takahashi K, Ohta Y, Mishiro S. 1998a. Partial ∼ 2.4-kb sequences of TT virus (TTV) genome from eight Japanese isolates: diagnostic and phylogenetic implications. Hepatol Res 12:111-120.
16. Takahashi K, Hoshino H, Ohta Y, Yoshida N, Mishiro S. 1998b. Very high prevalence of TT virus (TTV) infection in general population of Japan revealed by a new set of PCR primers. Hepatol Res 12: 233-239.
17. Tanaka Y, Mizokami M, Orito E, Ohno T, Nakano T, Kato T, Kato H, Mukaide M, Park Y-M, Kim B-S, Ueda R. 1998. New genotypes of TT virus (TTV) and a genotyping assay based on restriction fragment length polymorphism. FEBS Lett 437:201-206.
18. Viazov S, Ross RS, Niel C, de Oliveira JM, Varenholz C, Da Villa G, Roggendorf M. 1998. Sequence variability in the putative coding region of TT virus: evidence for two rather than several major types. J Gen Virol 79:3085-3089.