Assessment of P glycoprotein expression by immunocytochemistry and flow cytometry coupled with functional efflux analysis: Application to acute myeloid leukemia;Evaluation de l'expression de la glycoproteine P en immunocytochimie et en cytometrie de flux associee au test fonctionnel : application aux leucemies aigues myeloides

Annales de Biologie Clinique

Volumn 57, Issue 5, 1999, Pages 595-600

  Poulain, S ^a   Lepelley, P ^a   Cambier, N ^a   Wattel, E ^a   Fenaux, P ^a   Cosson, A ^a  

^a LILLE UNIVERSITY HOSPITAL   (France)

Author keywords

Immunostaining; P glycoprotein; Rhodamine 123 functional test

Indexed keywords

GLYCOPROTEIN P; MONOCLONAL ANTIBODY; RHODAMINE 123; VERAPAMIL;

ACUTE GRANULOCYTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; FLOW CYTOMETRY; HUMAN; IMMUNOCYTOCHEMISTRY; INTERMETHOD COMPARISON;

EID: 0032852291     PISSN: 00033898     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Gottesman M, Pastan I. Biochemistry of multidrug resistance mediated by the multidrug transportet. Annu Rev Biochemistry 1993 ; 62 : 385-427.
2. Z. Wattel E, Solary E, Hecquet B, et al., et le Groupe français des myélodysplasies. Quinine improves the results of intensive chemotherapy in myelodysplastic syndromes expressing P-glycoprotein : results of a randomized study. Br J Haematol 1998 ; 102 : 1015-24.
3. Beck W, Grognan T, Willman C, et al. Methods to detect P-glycoprotein-associated multidrug resistance in patients tumors : consensus recommendations. Cancer Research 1996 ; 56 : 3010-20.
4. Marie JP, Huet AM, Faussat AM, et al. Multicentric evaluation of the MDR phenotype in leukemia. Leukemia 1997 ; 11 : 1086-94.
5. - cases. Blood 1995 ; 86 : 2339-42.
6. Cole SPC, Defley RG. Multidrug resistance associated with overexpression of MRP. Cancer Treatment Res 1996 ; 87 : 39-62.
7. List AF. The role of multidrug resistance and its pharmacological modulation in acute myeloid leukemia. Leukemia 1996 ; 10 : 937-42.
8. Poulain S, Wattel E, Cambier N, et al. MRP expression in acute myeloid leukemia and myelodysplastic syndromes and its correlation with Pgp expression. Blood 1998 ; 92 : 389a.
9. Klimecki WT, Futscher BW, Grogan TM, Dalton WS. P-glycoprotein expression and function in circulating blood cells from normal volunters. Blood 1994 ; 83 : 2451-8.
10. Te Boekhorst P, Löwenberg B, van Kappel J, Nooter K, Sonneveld P. Multidrug resistant cells with high proliferative capacity determine response to therapy in acute myeloid leukemia. Leukemia 1995 ; 9 : 1025-31.