Influence of cyclodextrins on the in vitro corneal permeability and in vivo ocular distribution of thalidomide

Journal of Ocular Pharmacology and Therapeutics

Volumn 15, Issue 5, 1999, Pages 429-438

  Siefert, Burkhard ^a   Pleyer, Uwe ^b   Müller, Martina ^b   Hartmann, Christian ^b   Keipert, Sigrid ^b  

^a ASTELLAS PHARMA INC   (Japan)

^b HUMBOLDT UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ALPHA CYCLODEXTRIN; BETA CYCLODEXTRIN; CYCLODEXTRIN DERIVATIVE; DRUG VEHICLE; HYDROXYETHYL BETA CYCLODEXTRIN; HYDROXYPROPYL GAMMA CYCLODEXTRIN; METHYL BETA CYCLODEXTRIN; THALIDOMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AQUEOUS HUMOR; ARTICLE; CATTLE; CILIARY BODY; CONJUNCTIVA; CONTROLLED STUDY; CORNEA; CORNEA PERMEABILITY; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG TISSUE LEVEL; EYE; IN VITRO STUDY; IN VIVO STUDY; IRIS; MALE; NONHUMAN; RABBIT; SCLERA; SUSPENSION; TOPICAL DRUG ADMINISTRATION; VITREOUS BODY;

EID: 0032852111     PISSN: 10807683     EISSN: None     Source Type: Journal    
DOI: 10.1089/jop.1999.15.429     Document Type: Article

References (32)

1. Zwingenberger, K. and Wnendt, S. Immunomodulation by thalidomide: systematic review of the literature and of unpublished observations. J. Inflamm. 46:177-211, 1995.
2. Zhang, E.-P., Pleyer, U., Hoffmann, F. and Hartmann, C. Effect of thalidomide on experimental keratoplasty. Invest. Ophthalmol. Vis. Sci. 37:S867, 1996.
3. Neubert, R., Nogueira, A.C. and Neubert, D. Thalidomide derivatives and the immune system. I. Changes in the pattern of integral receptors and other surface markers on T lymphocyte subpopulations of marmoset blood. Arch. Tox. 67:1-17, 1993.
4. Baatz, H., Tönneßen, B., Pleyer, U. and Hartmann, C. Thalidomide inhibits leucocyte-endothelium-interaction in endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 38:S1159, 1997.
5. Guex-Crosier, Y., Pittet, N. and Herbort, C.P. The effect of thalidomide and supidimide on endotoxin-induced uveitis in rats. Graefes Arch. Clin. Exp. Ophthalmol. 233:90-93, 1995.
6. Schumacher, H., Smith, R.L. and Williams, R.T. The metabolism of thalidomide: The spontaneous hydrolysis of thalidomide in solution. Brit. J. Pharmacol. 25:324-337, 1965.
7. Koch, H.P. and Steinacker, C.H. Löslichkeits-und Stabilitätsverbesserung von Thalidomid durch Bildung von Einschlußkomplexen mit Cyclodextrinen. Arch. Pharm. 321:371-373, 1988.
8. Krenn, M., Gamcsik, M.P., Vogelsang, G.B., Colvin, O.M. and Leong, K.W. Improvements in solubility and stability of thalidomide upon complexation with hydroxypropyl-β-cyclodextrin. J. Pharm. Sci. 81:685-689, 1992.
9. Rajagopalan, N., Chen, S.C. and Chow, W.S. A study of the inclusion complex of amphotericin B in the presence of γ-cyclodextrin. Int. J. Pharm. 29:161-168, 1986.
10. Abdel Rahman, A.A., Khidr, S.H., Ahmed, S.M. and Aboutaleb, A.E. Evaluation of chloramphenicol-β-cyclodextrin inclusion complex. Eur. J. Pharm. Biopharm. 37:34-37, 1991.
11. Loftsson, T., Frioriksdóttir, H., Thórisdóttir, S., Stefánsson, E., Sigurdardóttir, A.M., Guomundsson, Ö. and Sigthórsson, T. 2-Hydroxypropyl-β-cyclodextrin in topical carbonic anhydrase inhibitor formulations. Eur. J. Pharm. Sci. 1:175-180, 1994.
12. Loftsson, T., Frioriksdóttir, H., Stefánsson, E., Thórisdóttir, S., Guomundsson, Ö. and Sigthórsson, T. Topically effective ocular hypotensive acetazolamide and ethoxyzolamide formulations in rabbits. J. Pharm. Pharmacol. 46:503-504, 1994.
13. Reer, O., Bock, T.K. and Müller, B.W. In vitro corneal permeability of Diclofenac sodium in formulations containing cyclodextrins compared to the commercial product Voltaren Ophtha. J. Pharm. Sci. 83:1345-1349, 1994.
14. Siefert, B. and Keipert, S. Influence of α-cyclodextrin and hydroxyalkylated β-cyclodextrin derivatives on the in vitro corneal uptake and permeation of aqueous pilocarpine-HCl solutions. J. Pharm. Sci. 86:716-720, 1997.
15. Hermes, W.A. Delivery of hormones: some new concepts. Pharm. Weekbl. Sci. 14:(4A):253-257, 1992.
16. Cheeks, L., Kaswan, R.L. and Green, K. Influence of vehicle and anterior chamber protein concentration on cyclosporine penetration through the isolated rabbit cornea. Curr. Eye Res. 11:641-649, 1992.
17. Kanai, A., Alba, R.M., Takano, T., Kobayashi, C., Nakajima, A., Kurihara, K., Yokoyama, T. and Fukami, M. The effect on the cornea of alpha-cyclodextrin vehicle for cyclosporin eye drops. Transplant Proc. 21:3150-3152, 1989.
18. Jansen, T., Xhonneux, B., Mesens, J. and Borgers, M. Beta-cyclodextrins as vehicles in eye drop formulations: An evaluation of their effects on rabbit corneal epithelium. Lens Eye Toxicity Res. 7:459-468, 1990.
19. Järvinen, K., Järvinen, T., Thompson, D.O. and Stella, V.J. The effect of a modified β-cyclodextrin, SBE4-β-CD, on the aqueous stability and ocular absorption of pilocarpine. Curr. Eye Res. 13:897-905, 1994.
20. Eriksson, T., Björkman, S., Fyge, A. and Ekberg, H. Determination of thalidomide in plasma and blood by high-performance liquid chromatography: avoiding hydrolytic degradation. J. Chrom. 582:211-216, 1992.
21. Kim, J.H., Green, K., Martinez, M. and Paton, D. Solute permeability of the corneal endothelium and Descemet's membrane. Exp. Eye Res. 12:231-238, 1971.
22. Usayapant, K., Karara, A.H. and Narurkar, M.M. Effect of 2-hydroxypropyl-β-cyclodextrin on the ocular absorption of dexamethasone and dexamethasone acetate. Pharm. Res. 8:1495-1499, 1991.
23. Freedman, K.A., Klein, J.W. and Crosson, C.E. Beta-cyclodextrins enhance bioavailability of pilocarpine. Curr. Eye Res. 12:641-647, 1993.
24. Keipert, S., Fedder, J., Böhm, A. and Hanke, B. Interactions between cyclodextrins and pilocarpine - as an example of a hydrophilic drug. Int. J. Pharm. 142:153-162, 1996.
25. Davies, N.M, Wang, G. and Tucker, I.G. Evaluation of a hydrocortisone/hydroxypropyl-β-cyclodextrin solution for ocular drug delivery. Int. J. Pharm. 156:201-209, 1997.
26. Masuda, K., Tohno, M., Konishi, Y., Kojima, H. and Matsumura, M. Ocular penetration of flurbiprofen, an anti-inflammatory drug, in rabbits after topical instillation. Atarashii Ganka 2:441-443, 1985.
27. Jarho, P., Järvinen, K., Urtti, A., Stella, V.J. and Järvinen, T. Modified β-cyclodextrin (SBE7-β-CYD) with viscous vehicle improves the ocular delivery and tolerability of pilocarpine prodrug in rabbits. J. Pharm. Pharmacol. 48:263-269, 1996.
28. Sieg, J.W. and Robinson, J.R. Vehicle effects on ocular drug bioavailability. I. Evaluation of fluoromethalone. J. Pharm. Sci. 64:931-936, 1975.
29. Chen, T.-L., Vogelsang, G.B., Petty, B.G., Brundrett, R.B., Noe, D.A., Santos, G.W. and Colvin, O.M. Plasma pharmacokinetics and urinary excretion of thalidomide after oral dosing in healthy male volunteers. Drug Metab. Dispos. 17:402-405, 1989.
30. Ahmed, I. and Patton, T.F. Importance of the noncorneal absorption route in topical ophthalmic drug delivery. Invest. Ophthalmol. Vis. Sci. 26:584-587, 1985.
31. Bloomfield, S.E., Miyata, T., Dunn, M.W., Bueser, N., Stenzel, K.H. and Rubin, A.L. Soluble gentamicin ophthalmic inserts as a drug delivery system. Arch. Ophthalmol. 96:885-887, 1978.
32. Bito, L.Z. and Baroody, R.A. The penetration of exogeneous prostaglandin and arachidonic acid into, and their distribution within, the mammalian eye. Curr. Eye Res. 1:659-668, 1982.