Iodinated radiographic contrast media inhibit shear stress- and agonist-evoked release of NO by the endothelium

British Journal of Pharmacology

Volumn 128, Issue 2, 1999, Pages 451-457

  Hutcheson, I R ^a   Griffith, T M ^a   Pitman, M R ^a   Towart, R ^b   Gregersen, M ^c   Refsum, Helge ^c,d   Karlsson, J O G ^c,e  

^a UNIVERSITY HOSPITAL OF WALES   (United Kingdom)

^b Nycomed Innovation AB   (Sweden)

^c NYCOMED IMAGING AS   (Norway)

^d ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^e LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Endothelium; Iodixanol; Iohexol; Iopromide; Nitric oxide; Vascular smooth muscle

Indexed keywords

ACETYLCHOLINE; CONTRAST MEDIUM; DEXTRAN; INDOMETACIN; IODIXANOL; IOHEXOL; IOPROMIDE; MANNITOL; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITROPRUSSIDE SODIUM;

ANGIOGRAPHY; ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPRESSOR RESPONSE; DOG; DRUG MECHANISM; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; SHEAR STRESS; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE; VISCOSITY;

EID: 0032852101     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702781     Document Type: Article

References (24)

1. ARAKAWA, K., SUZUKI, H., NAITOH, M., MATSUMOTO, A., HAYASHI, K., MATSUDA, H., ICHIHARA, A., KUBATO, E. & SARUTA, T. (1996). Role of adenosine in the renal responses to contrast medium. Kidney Int., 49, 1199-1206.
2. ALMÉN, T. (1995). Visipaque - a step forward. A historical review. Acta Radiol., 36, 2-18.
3. BAILE, E.M., WANG, L., VERBURGT, L. & PARE, P.D. (1997). Bronchial vasodilatory response to ionic and nonionic contrast media. J. Appl. Physiol., 82, 841-845.
4. CHAYTOR, A.T., EVANS, W.H. & GRIFFITH, T.M. (1998). Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J. Physiol. (London), 508, 561-573.
5. DOWELL, E.J. & MARTIN, W. (1997). The effects of peroxynitrite on rat aorta: interaction with glucose and related substances. Eur. J. Pharmacol., 338, 43-53.
6. FURCHGOTT, R.F. & ZAWADZKI, J.V. (1980). The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature, 228, 373-376.
7. GARLAND, C.J., PLANE, F., KEMP, B.K. & COCKS, T.M. (1995). Endothelium-dependent hyperpolarization: a role in the control of vascular tone. TIPS, 16, 23-30.
8. 2. Circ. Res., 84, 53-63.
9. HUTCHESON, I.R. & GRIFFITH, T.M. (1991). Release of endothelium-derived relaxing factor is modulated by both frequency and amplitude of pulsatile flow. Am. J. Physiol., 261, H257-H262.
10. HUTCHESON, I.R. & GRIFFITH, T.M. (1994). Heterogeneous populations of K ′ channels mediate EDRF release to flow but not antagonists in rabbit aorta. Am. J. Physiol., 266, H590-H596.
11. IGNARRO, L.J., BUGA, G.M., WOOD, K.S., BYRNS, R.E. & CHAUDHURI, G. (1987). Endothelium-derived relaxing factor (EDRF) produced and released from artery and vein is nitric oxide. Proc. Natl. Acad. Sci. U.S.A., 84, 9265-9269.
12. ISHIZAKA, H. & KUO, L. (1997). Endothelial ATP-sensitive potassium channels mediate coronary microvascular dilation to hyperosmolarity. Am. J. Physiol., 273, H104-H112.
13. KRISHNAMURTY, V.S., ADAMS, H.R., TEMPLETON, G.H. & WILLERSON, J.T. (1978). Inhibitory effect of hypertonic mannitol on vasoconstrictor and vasodilator responses of isolated coronary arteries. Am. J. Physiol., 235, H728-H735.
14. LINDGREN, P. (1970). Hemodynamic responses of contrast media. Invest. Radiol., 5, 424-435.
15. MONCADA, S., PALMER, R.M.J. & HIGGS, E.A. (1991). Nitric oxide: Physiology, pathophysiology and pharmacology. Pharmacol. Rev., 43, 109-142.
16. MORCOS, S.K., OLDROYD, S. & HAYLOR, J. (1997). Effect of radiographic contrast media on endothelium derived nitric oxide-dependent renal vasodilatation. Br. J. Radiol., 70, 154-159.
17. PALMER, R.M.J., FERRIGE, A.G. & MONCADA, S. (1987). Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature, 327, 5254-5260.
18. PITMAN, M.R., KARLSSON, J.O.G. & GRIFFITH, T.M. (1996). Ionic mechanisms contributing to the vasorelaxant properties of iodinated contrast media: a comparison of iohexol and iodixanol in the rabbit isolated aorta. Br. J. Pharmacol., 119, 685-690.
19. POHL, U., BUSSE, R., KUON, E. & BASSENGE, E. (1986). Pulsatile perfusion stimulates the release endothelial autocoids. J. Appl. Cardiol., 1, 215-235.
20. PUGH, N.D., HUTCHESON, I.R., EDWARDS, D.H., NOSSEN, J.Ø., KARLSSON, J.O.G. & GRIFFITH, T.M. (1995). Angiographic contrast media relax isolated rabbit aorta through an endothelium-independent mechanism that may not depend on the presence of the iodine atom. Br. J. Radiol., 6, 23-26.
21. PUGH, N.D. & KARLSSON, J.O.G. (1997). Vasodilator and hemorheological effects of iodinated contrast media. Drugs Today, 33, 191-203.
22. ROCHA, G., BUCHER, B., TSCHOPL, M. & STOCLET, J.C. (1995). Hyperosmolarity enhances smooth muscle contractile responses to phenylephrine and partially impairs nitric oxide production in the rat tail artery. J. Vasc. Res., 32, 58-65.
23. SCHWARTZ, D., BLUM, M., PEER, G., WOLLMAN, Y., MAREE, A., SERBAN, I., GROSSKOPF, I., CABILI, S., LEVO, Y. & IAINA, A. (1994). Role of nitric oxide (EDRF) in radiocontrast acute renal failure in rats. Am. J. Physiol., 267, F374-F379.
24. TESFAMARIAM, B. & COHEN, R.A. (1988). Inhibition of adrenergic vasoconstriction by endothelial shear stress. Circ. Res., 63, 720-725.