Unilateral focal lesions in the rostrolateral medulla influence chemosensitivity and breathing measured during wakefulness, sleep, and exercise

Journal of Neurology Neurosurgery and Psychiatry

Volumn 67, Issue 5, 1999, Pages 637-645

  Morrell, M J ^a,d   Heywood, P ^b   Moosavi, S H ^a   Guz, A ^a   Stevens, J ^c  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b FRENCHAY HOSPITAL   (United Kingdom)

^c ST MARY S HOSPITAL   (United Kingdom)

^d ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

Breathing; Lesion; Medulla; Sleep

Indexed keywords

CARBON DIOXIDE;

ADULT; AGED; ARTICLE; BRAIN INJURY; BRAIN REGION; BRAIN STEM; BREATHING; CHEMOSENSITIVITY; CLINICAL ARTICLE; CLINICAL EXAMINATION; CONTROLLED STUDY; EXERCISE; FEMALE; HUMAN; HYPOXEMIA; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PATIENT MONITORING; PRIORITY JOURNAL; ROSTROLATERAL MEDULLA; SLEEP; SLEEP APNEA SYNDROME; SLEEP DISORDER; WAKEFULNESS;

EID: 0032850802     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.67.5.637     Document Type: Article

References (30)

1. Plum F, Leigh RJ. Abnormalities of central mechanisms. In: Hornbein TF, ed. Regulation of breathing. New York: Marcel Dekker, Lung Biology in Health and Disease 1981;12:989-1067.
2. Chaudhary BA, Elguindi AS, King DW. Obstructive sleep apnea after lateral medullary syndrome. South Med J 1982; 75:65-7.
3. Bogousslavsky J, Khurana R, Deruaz JP, et al. Respiratory failure and unilateral caudal brainstem infarction. Ann Neurol 1990;28:668-73.
4. Vigerhoets F, Bogousslavsky J. Respiratory dysfunction in neuromuscular disease, respiratory dysfunction in stroke. Clin Chest Med 1994;15:729-37.
5. Martin PJ. Vertebrobasilar ischaemia. Q J Med 1998;91: 799-811.
6. Vuilleumier P, Bogousslavsky J, Regli F. Infarction of the lower brainstem: clinical, aetiological and MRI-topographical correlations. Brain 1995;118:1013-25.
7. Richter D, Ballantyne D, Remmers J. How is the respiratory rhythm generated? News in the Physiological Sciences 1986;109-12.
8. Bianchi AL, Grelot L, Iscoe S, et al. Electrophysiological properties of the rostral medullary areas in the cat. J Physiol Paris 1988;104:293-310.
9. Smith JC, Elllenberger HH, Ballanyi K, et al. Pre-Botzinger complex: a brainstem region that may generate respiratory rhythm in mammals. Science 1991;254:726-9.
10. Forster HV, Ohtake PJ, Lowry TF. Effects of breathing on surface ventrolateral medullary cooling in awake, anaesthetised and asleep goats. Respir Physiol 1997;110:187-97.
11. Forster HV, Pan LG, Lowry TF, et al. Breathing of awake goats during prolonged dysfunction of caudal M ventrolateral medullary neurones. J Appl Physiol 1998;84:129-40.
12. Akilesh MP, Kemper M, Li A, et al. Effects of unilateral lesions of retrotrapezoid nucleus on breathing in awake rats. J Appl Physiol 1997;82:469-79.
13. Heywood P, Morrell MJ, Moosavi S, et al. Ventilatory control awake, asleep and during exercise in man with unilateral rostral ventrolateral medullary lesions. International Congress of Physiological Societies. Glasgow: The Physiological Society of London, 1993:282.
14. Read D. A clinical method for assessing the ventilatory response to carbon dioxide. Australasian Annals of Medicine 1967;16:20-30.
15. Adams L, Chronos N, Lane R, et al. The measurement of breathlessness induced in normal subjects: validity of two scaling techniques. Clin Sci 1985;69:7-16.
16. Shea SA, Walter J, Murphy K, et al. Evidence for individuality of breathing patterns in resting healthy man. Respir Physiol 1987;68:331-44.
17. Rechtschaffen A, Kales A. A manual of standardized terminology, techniques and scoring systems for sleep stages of human subjects. Bethesda, Maryland: US Government Printing Office, 1968.
18. Innes AJ, DeCourt SC, Eans PJ, et al. Central command influences cardiopulmonary response to dynamic exercise in humans with unilateral weakness. J Physiol Lond 1992;448:551-63.
19. 2 in exercise. J Appl Physiol 1979;47:954-60.
20. Wasserman K, Hansen JE, Sue DY, et al. Principles of exercise testing and interpretation. Philadelphia: Lea and Febiger, 1987.
21. Haines DE. Neuroanatomy: an atlas of structures, sections and systems. 3rd ed. Baltimore: Williams and Wilkins, 1991.
22. 2 sensitive phrenic and sympathetic nerve activity. J Appl Physiol 1992;73:137-25.
23. Dampney R. The subretrofacial nucleus: it's pivotal role in cardiovascular regulation. News in Physiological Sciences 1990;5:63-7.
24. McAllen RM. Action and specificity of ventral medullary vesopressor neurones in the cat. Neuroscience 1996;18:51-9.
25. Bronstein A, Morris J, duBoulay G, et al. Abnormalities of horizontal gaze. Clinical, oculorgraphic and MRI findings. J Neurol Neurosurg Psychiatry 1990;53:194-9.
26. Forster HV, Lowery TF, Ohtake PJ, et al. Differential effect of ventrolateral medullary cooling on respiratory muscle of goats. J Appl Physiol 1995;78:1859-67.
27. Fink B. Influence of cerebral activity in wakefulness on regulation of breathing. J Appl Physiol 1961;16:15-20.
28. Shea SA, Andres LP, Shannon DC, et al. Ventilatory responses to exercise in humans lacking ventilatory chemosensitiviry. J Physiol Lond 1993;468:623-40.
29. 2 sensitivity in rats. Respir Physiol 1994;97:63-77.
30. Nattie EE, Li A. Rat retrotrapezoid nucleus iono- and metabotrophic glutamate receptors and the control of breathing. J Appl Physiol 1995;78:153-63.