Enhanced alloxan-induced β-cell damage and delayed recovery from hyperglycemia in mice lacking extracellular-superoxide dismutase

Free Radical Biology and Medicine

Volumn 27, Issue 7-8, 1999, Pages 790-796

  Sentman, Marie Louise ^a   Jonsson, Lena M ^a,b   Marklund, Stefan L ^a  

^a UMEÅ UNIVERSITY   (Sweden)

^b Eurona Medical AB   (Sweden)

Author keywords

Alloxan; Extracellular space; Free radicals; Hyperglycemia; Superoxide dismutase; Superoxide radicals

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; MANGANESE SUPEROXIDE DISMUTASE; OXYGEN RADICAL; SUPEROXIDE;

ALLOXAN DIABETES MELLITUS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; ENZYME LOCALIZATION; EXTRACELLULAR SPACE; FOLLOW UP; HYPERGLYCEMIA; MOUSE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; PROTECTION;

ALLOXAN; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, EXPERIMENTAL; FEMALE; FREE RADICALS; HYPERGLYCEMIA; ISLETS OF LANGERHANS; MICE; MICE, KNOCKOUT; SUPEROXIDE DISMUTASE; SUPEROXIDES;

EID: 0032849886     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-5849(99)00127-6     Document Type: Article

References (39)

1. Dunn J.S., Sheenan H.L., McLetchie N.G.B. Necrosis of islets of Langerhans-produced experimentally. Lancet. I:1943;484-487.
2. Deamer D.W., Heikkila R.E., Panganamala R.V., Cohen G., Cornwell D.G. The alloxan-dialuric acid cycle and the generation of hydrogen peroxide. Physiol. Chem. Phys. 3:1971;426-430.
3. Cohen G., Heikkila R.E. The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents. J. Biol. Chem. 249:1974;2447-2452.
4. · formation. Biochem. Pharmacol. 38:1989;271-277.
5. Grankvist K., Marklund S.L., Sehlin J., Täljedal I.B. Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro. Biochem. J. 182:1978;17-25.
6. Grankvist K., Marklund S., Täljedal I.B. Superoxide dismutase is a prophylactic against alloxan diabetes. Nature. 294:1981;158-160.
7. Kubisch H.M., Wang J., Luche R., Carlson E., Bray T.M., Epstein C.J., Phillips J.P. Transgenic copper/zinc superoxide dismutase modulates susceptibility to type I diabetes. Proc. Natl. Acad. Sci. USA. 91:1994;9956-9959.
8. Kubisch H.M., Wang J., Bray T.M., Phillips J.P. Targeted overexpression of Cu/Zn superoxide dismutase protects pancreatic β cells against oxidative stress. Diabetes. 46:1997;1563-1566.
9. McCord J.M., Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J. Biol. Chem. 244:1969;6049-6055.
10. Slot J.W., Geuze H.J., Freeman B.A., Crapo J.D. Intracellular localization of the copper-zinc and manganese superoxide dismutases in rat liver parenchymal cells. Lab. Invest. 55:1986;363-371.
11. Weisiger R.A., Fridovich I. Mitochondrial superoxide simutase. Site of synthesis and intramitochondrial localization. J. Biol. Chem. 248:1973;4793-4796.
12. Marklund S.L. Human copper-containing superoxide dismutase of high molecular weight. Proc. Natl. Acad. Sci. USA. 79:1982;7634-7638.
13. Karlsson K., Marklund S.L. Extracellular superoxide dismutase in the vascular system of mammals. Biochem. J. 255:1988;223-228.
14. Karlsson K., Marklund S.L. Binding of human extracellular-superoxide dismutase C to cultured cell lines and to blood cells. Lab. Invest. 60:1989;659-666.
15. Karlsson K., Sandström J., Edlund A., Marklund S.L. Turnover of extracellular-superoxide dismutase in tissues. Lab. Invest. 70:1994;705-710.
16. Winterbourn C.C., Stern A. Human red cells scavenge extracellular hydrogen peroxide and inhibit formation of hypochlorous acid and hydroxyl radical. J. Clin. Invest. 80:1987;1486-1491.
17. Carlsson L.M., Jonsson J., Edlund T., Marklund S.L. Mice lacking extracellular superoxide dismutase are more sensitive to hyperoxia. Proc. Natl. Acad. Sci. USA. 92:1995;6264-6268.
18. Patterson J.W., Lazarow A., Levey S. Alloxan and dialuric acid their stabilities and ultraviolet absorption spectra . J. Biol. Chem. 177:1948;187-196.
19. Marklund S.L. Spectrophotometric study of spontaneous dispropotionation of superoxide anion radical and sensitive direct assay for superoxide dismutase. J. Biol. Chem. 251:1976;7504-7507.
20. Marklund S.L. Direct assay of superoxide dismutase with potassium superoxide. Greenwald R.A. Handbook of methods for oxygen radical research. 1985;249-255 CRC Press Inc, Boca Raton, FL.
21. Marklund S.L. Analysis of extracellular superoxide dismutase in tissue homogenates and extracellular fluids. Methods Enzymol. 186:1990;260-265.
22. Boquist L. Pancreatic B-cell sensitivity to alloxan in vivo. A study of antagonizing compounds, serum inorganic phosphate and acid-base balance. Acta. Path. Microbiol. Scand. 86:1978;313-318.
23. Gandy S.E. III, Galbraith R.A., Crouch R.K., Buse M.G., Galbraith G.M. Superoxide dismutase in human islets of Langerhans [letter]. N. Engl. J. Med. 304:1981;1547-1548.
24. Thaete L.G., Crouch R.K., Schulte B.A., Spicer S.S. The immunolocalization of copper-zinc superoxide dismutase in canine tissues. J. Histochem. Cytochem. 31:1983;1399-1406.
25. Lynch R.E., Fridovich I. Permeation of the erythrocyte stroma by superoxide radical. J. Biol. Chem. 253:1978;4697-4699.
26. Sehlin, J. Univalent ions in islet cell function. Horm. Metab. Res. (Suppl. 10):73-80; 1980.
27. Corbett J.A., McDaniel M.L. Intraislet release of interleukin 1 inhibits beta cell function by inducing beta cell expression of inducible nitric oxide synthase. J. Exp. Med. 181:1995;559-568.
28. Rabinovitch A., Suarez Pinzon W.L., Sorensen O., Bleackley R.C. Inducible nitric oxide synthase (iNOS) in pancreatic islets of nonobese diabetic mice identification of iNOS- expressing cells and relationships to cytokines expressed in the islets . Endocrinology. 137:1996;2093-2099.
29. Huie R.E., Padmaja S. The reaction of NO with superoxide. Free Radic. Res. Commun. 18:1993;195-199.
30. Suarez Pinzon W.L., Szabo C., Rabinovitch A. Development of autoimmune diabetes in NOD mice is associated with the formation of peroxynitrite in pancreatic islet beta-cells. Diabetes. 46:1997;907-911.
31. Boquist L. The endocrine pancreas in early alloxan diabetes. Including study of the alloxan inhibitory effect of feeding and some hexoses. Acta. Pathol. Microbiol. Scand. 85A:1977;219-229.
32. Bunnag S.C., Warner N.E., Bunnag S. Effect of alloxan on the mouse pancreas during and after recovery from diabetes. Diabetes. 16:1967;83-89.
33. Waisbren B.A. Alloxan diabetes in mice. Proc. Soc. Exp. Biol. Med. 67:1948;154-156.
34. Wang R.N., Kloppel G., Bouwens L. Duct- to islet-cell differentiation and islet growth in the pancreas of duct-ligated adult rats. Diabetologia. 38:1995;1405-1411.
35. Wang R.N., Bouwens L., Kloppel G. Beta-cell proliferation in normal and streptozotocin-treated newborn rats site, dynamics and capacity . Diabetologia. 37:1994;1088-1096.
36. Wolff S.P., Dean R.T. Glucose autoxidation and protein modification. The potential role of 'autoxidative glycosylation' in diabetes. Biochem. J. 245:1987;243-250.
37. Sakurai T., Tsuchiya S. Superoxide production from nonenzymatically glycated protein. FEBS Lett. 236:1988;406-410.
38. Hattori Y., Kawasaki H., Abe K., Kanno M. Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta. Am. J. Physiol. 261:1991;H1086-H1094.
39. Yan S.D., Schmidt A.M., Anderson G.M., Zhang J., Brett J., Zou Y.S., Pinsky D., Stern D. Enhanced cellular oxidant stress by the interaction of advanced glycation end products with their receptors/binding proteins. J. Biol. Chem. 269:1994;9889-9897.