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Volumn 34, Issue 5, 1999, Pages 605-612

The mitochondrial theory of aging: Do damaged mitochondria accumulate by delayed degradation?

Author keywords

Damaged mitochondria; Mitochondrial DNA; Mitochondrial theory of aging; Superoxide radicals; Survival of the slowest

Indexed keywords

MITOCHONDRIAL DNA;

EID: 0032849153     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(99)00011-X     Document Type: Article
Times cited : (43)

References (42)
  • 3
    • 0029908304 scopus 로고    scopus 로고
    • Lipid peroxidation in mitochondrial inner membranes. I. An integrative kinetic model
    • Antunes F., Salvador A., Marinho H.S., Alves R., Pinto R.E. Lipid peroxidation in mitochondrial inner membranes. I. An integrative kinetic model. Free Radical Biol Med. 21:1996;917-943.
    • (1996) Free Radical Biol Med , vol.21 , pp. 917-943
    • Antunes, F.1    Salvador, A.2    Marinho, H.S.3    Alves, R.4    Pinto, R.E.5
  • 4
    • 0026782895 scopus 로고
    • Deleterious mitochondrial DNA mutations accumulate in aging human tissues
    • Arnheim N., Cortopassi G. Deleterious mitochondrial DNA mutations accumulate in aging human tissues. Mutat Res. 275:1992;157-167.
    • (1992) Mutat Res , vol.275 , pp. 157-167
    • Arnheim, N.1    Cortopassi, G.2
  • 5
    • 0025309791 scopus 로고
    • Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and aging?
    • Bandy B., Davison A.J. Mitochondrial mutations may increase oxidative stress implications for carcinogenesis and aging? Free Radical Biol Med. 8:1990;523-539.
    • (1990) Free Radical Biol Med , vol.8 , pp. 523-539
    • Bandy, B.1    Davison, A.J.2
  • 8
    • 0031885843 scopus 로고    scopus 로고
    • Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle
    • Brierley E.J., Johnson M.A., Lightowlers R.N., James O.F.W., Turnbull D.M. Role of mitochondrial DNA mutations in human aging Implications for the central nervous system and muscle . Ann Neurol. 43:1998;217-223.
    • (1998) Ann Neurol , vol.43 , pp. 217-223
    • Brierley, E.J.1    Johnson, M.A.2    Lightowlers, R.N.3    James, O.F.W.4    Turnbull, D.M.5
  • 9
    • 0018776894 scopus 로고
    • Hydroperoxide metabolism in mammalian organs
    • Chance B., Sies H., Boveris A. Hydroperoxide metabolism in mammalian organs. Physiol Rev. 59:1979;527-605.
    • (1979) Physiol Rev , vol.59 , pp. 527-605
    • Chance, B.1    Sies, H.2    Boveris, A.3
  • 11
    • 0025674177 scopus 로고
    • Detection of a specific mitochondrial DNA deletion in tissues of older individuals
    • Cortopassi G.A., Arnheim N. Detection of a specific mitochondrial DNA deletion in tissues of older individuals. Nucleic Acids Res. 18:1990;6927-6933.
    • (1990) Nucleic Acids Res , vol.18 , pp. 6927-6933
    • Cortopassi, G.A.1    Arnheim, N.2
  • 12
    • 0026732706 scopus 로고
    • A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues
    • Cortopassi G.A., Shibata D., Soong N.W., Arnheim N. A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci (USA). 89:1992;7370-7374.
    • (1992) Proc Natl Acad Sci (USA) , vol.89 , pp. 7370-7374
    • Cortopassi, G.A.1    Shibata, D.2    Soong, N.W.3    Arnheim, N.4
  • 13
    • 0023655369 scopus 로고
    • Protein damage and degradation by oxygen radicals
    • Davies K.J.A. Protein damage and degradation by oxygen radicals. J Biol Chem. 262:1987;9895-9901.
    • (1987) J Biol Chem , vol.262 , pp. 9895-9901
    • Davies, K.J.A.1
  • 14
    • 0002386563 scopus 로고    scopus 로고
    • A mechanism proposed to explain the rise in oxidative stress during aging
    • de Grey A.D.N.J. A mechanism proposed to explain the rise in oxidative stress during aging. J Anti-Aging Med. 1:1998;53-66.
    • (1998) J Anti-Aging Med , vol.1 , pp. 53-66
    • De Grey, A.D.N.J.1
  • 15
    • 0031081410 scopus 로고    scopus 로고
    • A proposed refinement of the mitochondrial free radical theory of aging
    • de Grey A.D.N.J. A proposed refinement of the mitochondrial free radical theory of aging. BioEssays. 19:1997;161-166.
    • (1997) BioEssays , vol.19 , pp. 161-166
    • De Grey, A.D.N.J.1
  • 16
    • 0029082812 scopus 로고
    • Mitochondrial respiration scavenges extramitochondrial superoxide anion via a nonenzymatic mechanism
    • Guidot D.M., Repine J.E., Kitlowski A.D., Flores S.C., Nelson S.K., Wright R.M. Mitochondrial respiration scavenges extramitochondrial superoxide anion via a nonenzymatic mechanism. J Clin Investi. 96:1995;1131-1136.
    • (1995) J Clin Investi , vol.96 , pp. 1131-1136
    • Guidot, D.M.1    Repine, J.E.2    Kitlowski, A.D.3    Flores, S.C.4    Nelson, S.K.5    Wright, R.M.6
  • 18
    • 0015319592 scopus 로고
    • The biologic clock: The mitochondria?
    • Harman D. The biologic clock the mitochondria? J Am Geriatr Soc. 20:1972;145-147.
    • (1972) J Am Geriatr Soc , vol.20 , pp. 145-147
    • Harman, D.1
  • 19
    • 0020516814 scopus 로고
    • Free radical theory of aging: Consequences of mitochondrial aging
    • Harman D. Free radical theory of aging consequences of mitochondrial aging . Age. 6:1983;86-94.
    • (1983) Age , vol.6 , pp. 86-94
    • Harman, D.1
  • 21
    • 0024437033 scopus 로고
    • Genetic toxicology of oxygen
    • Joenje H. Genetic toxicology of oxygen. Mutat Res. 219:1989;193-208.
    • (1989) Mutat Res , vol.219 , pp. 193-208
    • Joenje, H.1
  • 22
    • 0028349234 scopus 로고
    • Differential accumulations of 4977 bp deletion in mitochondrial DNA of various tissues in human aging
    • Lee H.C., Pang C.Y., Hsu H.S., Wei Y.H. Differential accumulations of 4977 bp deletion in mitochondrial DNA of various tissues in human aging. Biochim Biophys Acta. 1226:1994;37-43.
    • (1994) Biochim Biophys Acta , vol.1226 , pp. 37-43
    • Lee, H.C.1    Pang, C.Y.2    Hsu, H.S.3    Wei, Y.H.4
  • 24
    • 2942705669 scopus 로고
    • Mitochondrial DNA mutations as an important contributor to aging and degenerative diseases
    • Linnane A.W., Marzuki S., Ozawa T., Tanaka M. Mitochondrial DNA mutations as an important contributor to aging and degenerative diseases. Lancet March. 25:1989;642-645.
    • (1989) Lancet March , vol.25 , pp. 642-645
    • Linnane, A.W.1    Marzuki, S.2    Ozawa, T.3    Tanaka, M.4
  • 25
    • 0030931198 scopus 로고    scopus 로고
    • Quantitative allele-specific PCR: Demonstration of age-associated accumulation in human tissues of the A->G mutation at nucleotide 3243 in mitochondrial DNA
    • Liu V.W., Zhang C., Linnane A.W., Nagley P. Quantitative allele-specific PCR Demonstration of age-associated accumulation in human tissues of the A->G mutation at nucleotide 3243 in mitochondrial DNA . Hum Mutat. 9:1997;265-271.
    • (1997) Hum Mutat , vol.9 , pp. 265-271
    • Liu, V.W.1    Zhang, C.2    Linnane, A.W.3    Nagley, P.4
  • 26
    • 0023919282 scopus 로고
    • Genotoxicity of active oxygen species in mammalian cells
    • Meneghini R. Genotoxicity of active oxygen species in mammalian cells. Mutat Res. 195:1988;215-230.
    • (1988) Mutat Res , vol.195 , pp. 215-230
    • Meneghini, R.1
  • 29
    • 0027525966 scopus 로고
    • Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly
    • Müller-Höcker J., Seibel P., Schneiderbanger K., Kadenbach B. Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly. Virchows Arch (A). 422:1993;7-15.
    • (1993) Virchows Arch (A) , vol.422 , pp. 7-15
    • Müller-Höcker, J.1    Seibel, P.2    Schneiderbanger, K.3    Kadenbach, B.4
  • 30
    • 0027759243 scopus 로고
    • Human aging is associated with various point mutations in tRNA genes of mitochondrial DNA
    • Münscher C., Müller-Höcker J., Kadenbach B. Human aging is associated with various point mutations in tRNA genes of mitochondrial DNA. Biological Chemistry. 374:1993;1099-1104.
    • (1993) Biological Chemistry , vol.374 , pp. 1099-1104
    • Münscher, C.1    Müller-Höcker, J.2    Kadenbach, B.3
  • 32
    • 0017810263 scopus 로고
    • Do mitochondria produce oxygen radicals in vivo?
    • Nohl H., Hegner D. Do mitochondria produce oxygen radicals in vivo? Eur J Biochem. 82:1978;563-567.
    • (1978) Eur J Biochem , vol.82 , pp. 563-567
    • Nohl, H.1    Hegner, D.2
  • 34
    • 0015910803 scopus 로고
    • Free radical reactions and their importance in biochemical systems
    • Pryor W.A. Free radical reactions and their importance in biochemical systems. Fed Proc. 32:1973;1862-1869.
    • (1973) Fed Proc , vol.32 , pp. 1862-1869
    • Pryor, W.A.1
  • 35
    • 0004717610 scopus 로고    scopus 로고
    • Genomic and mitochondrial DNA alterations in aging
    • L.E. Schneider, & J.W. Rowe. New York: Academic Press
    • Randerath K., Randerath E., Filburn C. Genomic and mitochondrial DNA alterations in aging. Schneider L.E., Rowe J.W. Handbook of the biology of aging. 1996;198-214 Academic Press, New York.
    • (1996) Handbook of the Biology of Aging , pp. 198-214
    • Randerath, K.1    Randerath, E.2    Filburn, C.3
  • 36
    • 0024266283 scopus 로고
    • Do mitochondrial DNA fragments promote cancer and aging?
    • Richter C. Do mitochondrial DNA fragments promote cancer and aging? FEBS Lett. 241:1988;1-5.
    • (1988) FEBS Lett , vol.241 , pp. 1-5
    • Richter, C.1
  • 37
    • 0025276996 scopus 로고
    • Deletion mutants are functionally dominant over wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial disease
    • Shoubridge E.A., Karpati G., Hastings K.E.M. Deletion mutants are functionally dominant over wild-type mitochondrial genomes in skeletal muscle fiber segments in mitochondrial disease. Cell. 62:1990;43-49.
    • (1990) Cell , vol.62 , pp. 43-49
    • Shoubridge, E.A.1    Karpati, G.2    Hastings, K.E.M.3
  • 38
    • 0027182560 scopus 로고
    • Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages
    • Sugiyama S., Takasawa M., Hayakawa M., Ozawa T. Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages. Biochem Mol Biol Int. 30:1993;937-944.
    • (1993) Biochem Mol Biol Int , vol.30 , pp. 937-944
    • Sugiyama, S.1    Takasawa, M.2    Hayakawa, M.3    Ozawa, T.4
  • 39
    • 0024541068 scopus 로고
    • Mitochondrial DNA mutations and neuromuscular disease
    • Wallace D.C. Mitochondrial DNA mutations and neuromuscular disease. Trends Genet. 5:1989;9-13.
    • (1989) Trends Genet , vol.5 , pp. 9-13
    • Wallace, D.C.1
  • 40
    • 0022644072 scopus 로고
    • Free radicals, lipids and protein degradation
    • Wolff S.P., Garner A., Dean R.T. Free radicals, lipids and protein degradation. Trends Biochem Sci. 11:1986;27-31.
    • (1986) Trends Biochem Sci , vol.11 , pp. 27-31
    • Wolff, S.P.1    Garner, A.2    Dean, R.T.3
  • 41
    • 0025741445 scopus 로고
    • Aging-associated 5 kb deletion in human liver mitochondrial DNA
    • Yen T.-C., Su J.-H., King K.-L., Wei Y.-H. Aging-associated 5 kb deletion in human liver mitochondrial DNA. Biochem Biophys Commun. 178:1991;124-131.
    • (1991) Biochem Biophys Commun , vol.178 , pp. 124-131
    • Yen, T.-C.1    Su, J.-H.2    King, K.-L.3    Wei, Y.-H.4
  • 42
    • 0030583123 scopus 로고    scopus 로고
    • Comparison of different quantitative PCR procedures in the analysis of the 4977-bp deletion in human mitochondrial DNA
    • Zhang C., Peters L.E., Linnane A.W., Nagley P. Comparison of different quantitative PCR procedures in the analysis of the 4977-bp deletion in human mitochondrial DNA. Biochem Biophys Res Commun. 223:1996;450-455.
    • (1996) Biochem Biophys Res Commun , vol.223 , pp. 450-455
    • Zhang, C.1    Peters, L.E.2    Linnane, A.W.3    Nagley, P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.