Determination of partition coefficients for several propranolol analogues by reversed phase high performance liquid chromatography

Journal of Liquid Chromatography and Related Technologies

Volumn 22, Issue 14, 1999, Pages 2139-2149

  Britto, Marcelo M ^a   Cass, Quezia B ^b   Montanari, Carlos A I ^a   Aboul Enein, Hassan Y ^c  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO CARLOS   (Brazil)

^c KING FAISAL SPECIALIST HOSPITAL AND RESEARCH CENTER   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORINE; PROPRANOLOL DERIVATIVE;

ARTICLE; DRUG DETERMINATION; DRUG STRUCTURE; HYDROGEN BOND; PARTITION COEFFICIENT; POLARIZATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

EID: 0032849125     PISSN: 10826076     EISSN: None     Source Type: Journal    
DOI: 10.1081/JLC-100101790     Document Type: Article

References (24)

1. th edition, Prentice-Hall International Inc., Englewood Cliffs, New Jersey, 1992.
2. S. A. Stephen, Am.J.Cardiol., 18, 463 (1996).
3. M. C. Cheitlin, W. H. Frishman, C. W. Weart, Patient Care, August 15, 1993, p. 21.
4. H. Y. Aboul-Enein, Toxicol-Environm.Chem., 29, 235 (1991).
5. R. Filler, Y. Kobayashi, L. M. Yagupolskii, eds., Organo-Fluorine Compounds in Medicinal Chemistry and Biomedical Applications, Elsevier, Amsterdam, The Netherlands, 1993.
6. W. B. Weglicki, I. T. Mak, H. Y. Aboul-Enein, Fluorinated Propranolol and Related Methods, U. S. Patent 5, 776, 985, July 7, 1998.
7. Z. H. Farooqi, H. Y. Aboul-Enein, Struct.Chem., 6, 349 (1995).
8. H. Y. Aboul-Enein, L. Abou-Basha, S. Bakr, Chirality, 8, 153 (1996).
9. H. Y. Aboul-Enein, S. A. Bakr, J.Liq.Chrom.&Rel.Technol., 21, 1137 (1998).
10. R. Kaliszan, Quantitative Structure-Chromatographic Retention Relationships, Chemical Analysis, Vol. 93, John Wily & Sons, New York, 1987.
11. M. L. C. Montanari, D. Piló-Veloso, Q. B. Cass, C. A. Montanari, J. Liq. Chrom. & Rel. Technol., 20, 1703 (1997).
12. M. M. Britto, C. A. Montanari, C. L. Donnici, Q. B. Cass, J. Liq. Chromat. & Rel. Technol (in press).
13. M. L. C. Montanari, A. E. Beezer, C. A. Montanari, D. Piló-Veloso, P. L. O. Volpe, J. C. Mitchell, Quant.Struct.-Act.Relat.,17, 102 (1998).
14. A. Leo, C. Hansch, D. Elkins, Chem. Rev., 71, 525 (1971).
15. P. Boudeville, M. Bona, J. L. Burgot, J. Pharm. Sci., 85, 990 (1996).
16. D. Corradini, K. Kalghatgi, C. Horvath, J. Chromatogr. A, 728, 225 (1996).
17. H. van de Wateerbemd, M. Kansy, B. Wagner, H. Fischer, "Lipophilicity in Drug Action and Toxicology," in Methods and Principles in Medicinal Chemistry," R. Mannhold, H. Kubinyi, H. Timmerman, eds., Vol. 4, VCH, Weinheim, Germany, 1996, p. 73-87.
18. M. Kansy, H. Fischer, H. van de Waterbeemd, in QSAR and Molecular Modelling: Concepts, Computational Tools and Biological Applications," F. Sanz, J. Giraldo, F. Manaut, eds., J. R. Prous Publishers, Barcelona, Spain, 1995, pp 45-48.
19. D. J. Minick, D. A. Brent, J. H. Frenz, J Chromatogr., 461, 177 (1989).
20. N. El Tayar, H. van de Waterbeemd, B. Testa, Quant Struct. -Act. Relat., 4, 69 (1985).
21. D. J. Minick, J. H. Frenz, M. A. Patrick, D. A. Brent, J. .Med. Chem., 31, 1923 (1988).
22. A. Avdeef, Methods and Principles in Medicinal Chemistry, R. Mannhold, R., H. Kubinyi, H. and H. Timmerman, eds.; Lipophilicity in Drug Action and Toxicology, V. Pliška, B. Testa, B. and H. van de Waterbeemd, eds., Vol. 4, VCH Weinheim, Germany, 1995, p. 109.
23. A. Avdeef, Methods and Principles in Medicinal Chemistry, R. Mannhold, R., H. Kubinyi, H. and H. Timmerman, eds.; Lipophilicity in Drug Action and Toxicology, V. Pliška, B. Testa, B. and H. van de Waterbeemd, eds., Vol. 4, VCH Weinheim, Germany, 1995, p. 109.
24. C. Hansch, A. Leo, D. Hoekman, in Exploring QSAR: Hydrophobic, Electronic, and Steric Constants, ACS, Washington, DC, 1995, p. 143.