Histopathologic evaluation of hepatocellular carcinoma with special reference to small early stage tumors

Seminars in Liver Disease

Volumn 19, Issue 3, 1999, Pages 287-296

  Kojiro, Masamichi ^a   Nakashima, Osamu ^a  

^a KURUME UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Hepatocellular carcinoma; Multicentric occurrence; Premalignant lesion

Indexed keywords

ARTICLE; CANCER RISK; CELL PROLIFERATION; EARLY CANCER; HISTOPATHOLOGY; HUMAN; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; PRECANCER; PRIORITY JOURNAL; TUMOR DIFFERENTIATION; TUMOR VOLUME;

EID: 0032848301     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-1007118     Document Type: Article

References (47)

1. Bruix J. Treatment of hepatocellular carcinoma. Hepatology 1997;25:259-262
2. Colombo M, de Franchis R, Del Ninno B, et al. Hepatocellular carcinoma in Italian patients with cirrhosis. N Engl J Med 1991;325:675-680
3. Ohto M, Karasawa E, Tsuchiya Y, et al. Ultrasonically guided percutaneous contrast medium injection and aspiration biopsy using a real time transducer. Radiology 1980;136:171-176
4. Okuda K. Hepatocellular carcinoma: recent progress. Hepatology 1992;15:948-963
5. Kanai T, Hirohashi S, Upton M, et al. Pathology of small hepatocellular carcinoma. A proposal for a new gross classification. Cancer 1987;60:810-819
6. Kojiro M, Sugihara S, Nakashima O. Pathomorphologic characteristics of early hepatocellular carcinoma. In: K Okuda, T Tobe, T Kiwagawa, eds. Early Detection and Treatment of Liver Cancer. Tokyo: Japan Scientific Societies Press; 1991
7. Kondo Y, Niwa Y, Akikusa B, et al. A histopathologic study of early hepatocellular carcinoma. Cancer 1983;52:687-692
8. Nagato Y, Kondo Y, Kondo F, et al. Histological and morphological indicators for a biopsy diagnosis of well-differentiated hepatocellular carcinoma. Hepatology 1991;14:473-478
9. Nakashima O, Sugihara S, Kage M, et al. Pathomorphologic characteristics of small hepatocellular carcinoma: A special reference to small hepatocellular carcinoma with indistinct margins. Hepatology 1995;22:101-105
10. Tomizawa M, Kondo F, Kondo Y, et al. Growth patterns and interstitial invasion of small hepatocellular carcinoma. Pathol Int 1995;45:352-358
11. Kojiro M. Pathology of early hepatocellular carcinoma - progression from early to advanced. Hepatogastroenterology 1998; 45:1203-1205
12. Sakamoto M, Hirohashi S, Shimosato Y. Early stage of multistep hepatocarcinogenesis: Adenomatous hyperplasia and early hepatocellular carcinoma. Human Pathol 1991;22:172-178
13. Takayama T, Makuuchi M, Hirohashi S, et al. Malignant transformation of adenomatous hyperplasia to hepatocellular carcinoma. Lancet 1990;336:1150-1153
14. Arakawa M, Kage M, Sugihara S, et al. Emergence of malignant lesions within an adenomatous hyperplastic nodule in a cirrhotic liver. Observations in five cases. Gastroenterology 1986;91: 198-208
15. International Working Party. Terminology of nodular hepatocellular lesions. Hepatology 1995;17:27-35
16. Kondo Y, Kondo F, Nagato Y, et al. Interstitial tumor cell invasion of small hepatocellular carcinoma. Evaluation in microscopic and low magnification views. J Gastroenterol Hepatol 1994;9:604-612
17. Takayasu K. Hepatic angiography. In: K Okuda, E Tabor, eds. Liver Cancer. New York: Churchill Livingstone, 1997, 347-359
18. Kenmochi K, Sugihara S, Kojiro M. Relationship of histologic grade of hepatocellular carcinoma (HCC) to tumor size, and demonstration of tumor cells of multiple different grades in a single small HCC. Liver 1987;7:18-26
19. Sugihara S, Nakashima O, Kojiro M, et al. The morphologic transition in hepatocellular carcinoma. A comparison of the individual histological features disclosed by ultrasound-guided fine-needle biopsy at autopsy. Cancer 1992;70: 1488-1492
20. Tabor E. The role of tumor suppressor genes in the development of hepatocellular carcinoma. In: K Okuda, E Tabor, eds. Liver Cancer. New York: Churchill Livingstone, 1997, 89-95
21. Geissler M, Gesien A, Wands RJ. Molecular mechanisms of hepatocarcinogenesis. In: K Okuda, E Tabor, eds. New York: Churchill Livingstone, 1997, 59-88
22. Nakashima Y, Hsia C, Yuwen H, et al. p53 overexpression in small hepatocellular carcinoma containing two different histologie grades. Int J Oncol 1998;12:455-459
23. Morimitsu Y, Hsia C, Kojiro M, et al. Nodules of less-differentiated tumor within or adjacent to hepatocellular carcinoma. Relative expression of transforming growth factor-α and its receptor in the different areas of tumor. Hum Pathol 1995;26:1126-1132
24. Koga H, Sakisaka S, Ohishi M, et al. Expression of cyclooxygenase-2 in human hepatocellular carcinoma: Relevance to tumor dedifferentiation. Hepatology 1999; 29:688-696
25. x:320-327
26. Sakamoto M, Hirohashi S, Shimosato Y. Early stages of multistep hepatocarcinogenesis: adenomatous hyperplasia and hepatocellular carcinoma. Hum Pathol 1991;22:172-178
27. Liver Cancer Study Group of Japan. Classification of Primary Liver Cancer. Tokyo: Kanehara, Co. Ltd, 1997
28. Furuya K, Nakamura M, Yamamoto Y, et al. Macroregenerative nodule of the liver. A clinicopathological study of 345 autopsy cases of chronic liver disease. Cancer 1988;61:99-105
29. Ferrell L, Wright Y, Lake J, et al. Incidence and diagnostic features of macroregenerative nodules vs small hepatocellular carcinoma in cirrhotic liver. Hepatology 1992;16:1372-1381
30. Theise N. Macroregenerative (dysplastic) nodules and hepatocarcinogenesis: Theoretical and clinical considerations. Sem Liver Dis 1995;15:360-371
31. Gibson J, Sobin L. Histological Typing of Tumours of the Liver, Biliary Tracts and Pancreas. Geneva: World Health Organization, 1978
32. Edmondson H. Benign epithelial tumors and tumor-like lesions of the liver. In: K Okuda, R Peters, eds. Hepatocellular Carcinoma. New York: Wiley Medical, 1976, pp 309-332
33. Le Bail B, Belleannee G, Bernard P-H, et al. Adenomatous hyperplasia in cirrhotic livers: histological evaluation, cellular density, and proliferative activity of 35 lesions in cirrhotic explants of 10 adult French patients. Hum Pathol 1995;26:897-906
34. Ishak K, Anthony P, Sobin L. Histological Typing of Tumours of the Liver, 2nd ed. New York: Springer-Verlag, 1994
35. Nakanuma Y, Terada T, Terasaki S, et al. "Atypical adenomatous hyperplasia" in liver cirrhosis: low grade hepatocellular carcinoma or borderline lesion? Histopathology 1990;17:27-36
36. Arakawa M, Kage M, Sugihara S, et al. Emergence of malignant lesions within adenomatous hyperplastic nodule in cirrhotic liver: observation in five cases. Gastroenterology 1986;91: 198-208
37. Ohno Y, Shiga J, Machinami R, et al. A histopathological study of five cases of adenomatous hyperplasia containing minute hepatocellular carcinoma. Acta Pathol Jpn 1990;40:267-278
38. Sakurai M, Wakasa K, Monden M, et al. Hepatocellular carcinoma in adenomatous hyperplasia. Cancer Chemother 1989;23: s110-113
39. Eguchi A, Nakashima O, Okudaira S, et al. Adenomatous hyperplasia in the vicinity of small hepatocellular carcinoma. Hepatology 1992;15:843-848
40. Terada T, Nakanuma Y. Survey of iron-accumulative macroregenerative nodules in cirrhotic liver. Hepatology 1989;5: 851-854
41. Terada T, Nakanuma Y. Iron-negative foci in siderotic macroregenerative nodules in human cirrhotic livers: a marker of incipient pre-neoplastic or neoplastic lesions. Arch Pathol Lab Med 1993;113:916-920
42. Takenaka K, Adachi E, Nishizaki T, et al. Possible multicentric occurrence of hepatocellular carcinoma: A clinicopathological study. Hepatology 1994;19:889-894
43. Kumada T, Nakano S, Takeda I, et al. Patterns of recurrence after initial treatment in patients with small hepatocellular carcinoma. Hepatology 1997;25:87-92
44. Tarao K, Hoshino H, Shimizu A, et al. Role of increased DNA synthesis activity of hepatocytes in multicentric hepatocarcinogenesis, in residual liver of hepatectomized cirrhotic patients with hepatocellular carcinoma. Jpn J Cancer Res 1994;85: 1040-1044
45. Sakamoto M, Hirohashi S, Tsuda H, et al. Multicentric independent development of hepatocellular carcinoma revealed by analysis of hepatitis B virus integration pattern. Am J Surg Pathol 1989;13:1064-1067
46. Hsu H, Chiou T, Chen J, et al. Clonality and clonal evolution of hepatocellular carcinoma with multiple nodules. Hepatology 1991;13:923-928
47. Oda T, Tsuda H, Scarpa A, et al. Mutation pattern of the p53 gene as a diagnostic marker for multiple hepatocellular carcinoma. Cancer Res 1992;52:3674-3678