Two highly related homeodomain proteins, Nkx5-1 and Nkx5-2, display different DNA binding specificities

Biological Chemistry

Volumn 380, Issue 9, 1999, Pages 1041-1048

  Mennerich, Detlev ^a   Hoffmann, Sonja ^a   Hadrys, Thorsten ^a   Arnold, Hans Henning ^a   Bober, Eva ^a  

^a TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

Binding site selection; Homeodomain; Nkx5 genes; Transcription factors

Indexed keywords

HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; INNER EAR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; DNA; GLUTATHIONE TRANSFERASE; HOMEODOMAIN PROTEINS; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

VERTEBRATA;

EID: 0032847474     PISSN: 14316730     EISSN: None     Source Type: Journal    
DOI: 10.1515/BC.1999.130     Document Type: Article

References (35)

1. Azpiazu, N., and Frasch, M. (1993). tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila. Genes Dev. 7, 1325-1340.
2. Billeter, M., Qian, Y.Q., Otting, G., Muller, M., Gehring, W., and Wüthrich, K. (1993). Determination of the nuclear magnetic resonance solution structure of an Antennapedia homeodomain-DNA complex. J. Mol. Biol. 234, 1084-1093.
3. Bober, E., Baum, C., Braun, T., and Arnold, H.-H. (1994). A novel NK-related mouse homeobox gene: expression in central and peripheral nervous structures during embryonic development. Dev. Biol. 162, 288-303.
4. Bodmer, R. (1993). The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development 118, 719-729.
5. Chen, C.Y., and Schwartz, R.J. (1995). Identification of novel DNA binding targets and regulatory domains of a murine tinman homeodomain factor, Nkx-2.5. J. Biol. Chem. 270, 15628-15633.
6. Civitareale, D., Castelli, M.P., Falasca, P., and Saiardi, A. (1993). Thyroid transcription factor 1 activates the promoter of the thyrotropin receptor gene. Mol. Endocrinol. 7, 1589-1595.
7. Damante, G., Fabbro, D., Pellizzari, L., Civitareale, D., Guazzi, S., Polycarpou-Schwarz, M., Cauci, S., Quadrifoglio, F., Formisano, S., and Di Lauro, R. (1994). Sequence-specific DNA recognition by the thyroid transcription factor-1 homeodomain. Nucleic Acids Res. 22, 3075-3083.
8. Deitcher, D.L., Fekete, D.M., and Cepko, C.L. (1994). Asymmetric expression of a novel homeobox gene in vertebrate sensory organs. J. Neurosci. 14, 486-498.
9. Dohrmann, C., Azpiazu, N., and Frasch, M. (1990). A new Drosophila homeo box gene is expressed in mesodermal precursor cells of distinct muscles during embryogenesis. Genes Dev. 4, 2098-2111.
10. Ekker, S.C., von Kessler, D.P., and Beachy, P.A. (1992). Differential DNA sequence recognition is a determinant of specificity in homeotic gene action. EMBO J. 11, 4059-4072.
11. Ekker, S.C., Jackson, D.G., von Kessler, D.P., Sun, B.I., Young, K.E., and Beachy, P.A. (1994). The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. EMBO J. 13, 3551-3560.
12. Guazzi, S., Price, M., De Felice, M., Damante, G., Mattei, M.-G., and Di Lauro, R. (1990). Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity. EMBO J. 9, 3631-3639.
13. Hadrys, T., Braun, T., Rinkwitz-Brandt, S., Arnold, H.-H., and Bober, E. (1998). Nkx5-1 controls semicircular canal formation. Development 125, 33-39.
14. Harvey, R. (1996). NK-2 homeobox genes and heart development. Dev. Biol. 178, 203-216.
15. Hennighausen, L., and Lubon, H. (1987). Interaction of protein with DNA in vitro. Methods Enzymol. 152, 721-735.
16. Herbrand, H., Guthrie, S., Hadrys, T., Hoffmann, S., Arnold, H.-H., Rinkwitz-Brandt, S., and Bober, E. (1998). Two regulatory genes, cNkx5-1 and cPax2, show different responses to local signals during otic placode and vesicle formation in the chick embryo. Development 125, 645-654.
17. Johnson, A. (1993). In: Transcriptional Regulation, K. Yamamoto and S. McKnight, eds. (Cold Spring Harbor, New York: CSHL press) pp. 975-1006.
18. Kalionis, B., and O'Farrell, P.H. (1993). A universal target sequence is bound in vitro by diverse homeodomains. Mech. Dev. 43, 57-70.
19. Kim, Y., and Nirenberg, M. (1989). Drosophila NK-homeobox genes. Proc. Natl. Acad. Sci. USA 86, 7716-7720.
20. Kimura, S., Hara, Y., Pineau, T., and Fernandez-Salguero, P. (1996). The T/ebp null mouse: Thyroid-specific enhancer-binding protein is essential for organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev. 10, 60-69.
21. Kissinger, C.R., Liu, B., Martin-Blanco, E., Kornberg, T.B., and Pabo, C.O. (1990). Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: a framework for understanding homeodomain-DNA interactions. Cell 63, 579-590.
22. Lyons, I., Parsons, L.M., Hartley, L., Li, R., Andrews, J., Robb, L., and Harvey, R.P. (1995). Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeobox gene Nkx2-5. Genes Dev. 9, 1654-1666.
23. Mann, R.S. (1995). The specificity of homeotic gene function. Bioessays 17, 855-863.
24. Martinez, P., and Davidson, E.H. (1997). SpHmx, a sea urchin homeobox gene expressed in embryonic pigment cells. Dev. Biol. 181, 213-222.
25. Norby, P.L., Pallisgaard, N., Pedersen, F.S., and Jorgensen, P. (1992). Determination of recognition-sequences for DNA-binding proteins by a polymerase chain reaction assisted binding site selection method (BSS) using nitrocellulose immobilized DNA binding protein. Nucl. Acids Res. 20, 6317-6321.
26. Okkema, P.G., and Fire, A. (1994). The Caenorhabditis elegans NK-2 class homeoprotein CEH-22 is involved in combinatorial activation of gene expression in pharyngeal muscle. Development 120, 2175-2186.
27. Ray, M.K., Chen, C.-Y., Schwartz, R.J., and De Mayo, F.J. (1996). Transcriptional regulation of a mouse Clara cell-specific protein (mCC10) gene by the Nkx transcription factor family members thyroid transcription factor 1 and cardiac muscle-specific homeobox protein (CSX). Mol. Cell Biol. 16, 2056-2064.
28. Rinkwitz-Brandt, S., Justus, M., Oldenettel, I., Arnold, H.-H., and Bober, E. (1995). Distinct temporal expression of mouse Nkx5-1 and Nkx5-2 homeobox genes during brain and inner ear development. Mech. Dev. 52, 371-381.
29. Roberts, C.V.M., Shutter, J.R., and Korsmeyer, S.J. (1994). Hox11 controls the genesis of the spleen. Nature 368, 747-749.
30. Roth, M.B., Zahler, A.M., and Stolk, J.A. (1991). A conserved family of nuclear phosphoproteins localized to sites of polymerase II transcription. J. Cell Biol. 115, 587-596.
31. Stadler, H.S., Padanilam, B.J., Buetow, K., Murray, J.C., and Solursh, M. (1992). Identification and genetic mapping of a homeobox gene to the 4p16.1 region of human chromosome 4. Proc. Natl. Acad. Sci. USA 89, 11579-11583.
32. Stadler, H.S., and Solursh, M. (1994). Characterization of the homeobox-containing gene GH6 identifies novel regions of homeobox gene expression in the developing chick embryo. Dev. Biol. 161, 251-262.
33. Stadler, H.S., Murray, J.C., Leysens, N.J., Goodfellow, P.J., and Solursh, M. (1995). Phylogenetic conservation and physical mapping of members of the H6 homeobox gene family. Mammalian Genome 6, 383-388.
34. Wang, W., Van De Water, T., and Lufkin, T. (1998). Inner ear and maternal reproductive defects in mice lacking the Hmx3 homeobox gene. Development 125, 621-634.
35. Wright, W.E., and Funk, W.D. (1993). CASTing for multicomponent DNA-binding complexes. Trends Biochem. Sci. 18, 77-80.