Deconstructing the antigenic profile of a protective epitope from measles virus fusion protein using overlapping peptides

Vaccine

Volumn 18, Issue 3-4, 1999, Pages 321-324

  Partidos, C D ^a   Salani, F B ^a   Ripley, J ^b   Steward, M W ^b  

^a ROYAL VETERINARY COLLEGE   (United Kingdom)

^b LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

Antigenicity; B cell epitopes; Peptides

Indexed keywords

EPITOPE; MEASLES VACCINE; SYNTHETIC PEPTIDE; VIRUS FUSION PROTEIN;

AMINO ACID SEQUENCE; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIGENICITY; B LYMPHOCYTE; CONFERENCE PAPER; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNIZATION; MEASLES VIRUS; MOUSE; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, VIRAL; EPITOPES; MEASLES VIRUS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; MOLECULAR SEQUENCE DATA; VIRAL FUSION PROTEINS;

EID: 0032847342     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(99)00211-X     Document Type: Conference Paper

References (7)

1. Benjamin D.C., Berzofsky J.A., East I.J., Gurd F.R.N., Hannum C., Leach S.J., Margoliash E., Michael J.G., Miller A., Prager E.M., Reichlen M., Sercarz E.E., Smith-Gill S.J., Todd P.E., Wilson A.C. The antigenic structure of proteins: a reappraisal. Annu. Rev. Immunol. 2:1984;67-101.
2. Partidos C.D., Ripley J., Delmas A., Obeid O.E., Denbury A., Steward M.W. Fine specificity of the antibody response to a synthetic peptide from the fusion protein and protection against measles virus-induced encephalitis in a mouse model. J. Gen. Virol. 78:1997;3227-3232.
3. Geysen H.M. Antigen-antibody interactions at the molecular level: adventures of peptide synthesis. Immunol. Today. 6:1985;364-369.
4. Geysen H.M., Meloen R.H., Barteling S.I. Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid. Proc. Natl. Acad. Sci. USA. 81:1984;3998-4002.
5. Geysen H.M., Rodda S.J., Mason T.J., Tribbick G., Schoofs P.G. Strategies for epitope analysis using peptide synthesis. J. Immunol. Methods. 102:1987;259-265.
6. Frank R. Spot-synthesis:an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support. Tetrahedron. 00:1992;9217-9223.
7. Halimi H., Dumortier H., Briand J.P., Muller S. Comparison of two different methods using overlapping synthetic peptides for localizing linear B-cell epitopes in the UI snRNP-C autoantigen. J. Immunol. Methods. 199:1996;77-85.