Investigation of the quantitative metabolic fate and urinary excretion of 3-methyl-4-trifluoromethylaniline and 3-methyl-4- trifluoromethylacetanilide in the rat

Drug Metabolism and Disposition

Volumn 27, Issue 10, 1999, Pages 1171-1178

  Scarfe, Graeme B ^a   Lindon, John C ^a   Nicholson, Jeremy K ^a   Wright, Brian ^b   Clayton, Eddie ^b   Wilson, Ian D ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYL 4 TRIFLUOROMETHYLACETANILIDE; 3 METHYL 4 TRIFLUOROMETHYLANILINE; ACETANILIDE DERIVATIVE; AROMATIC AMINE; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL EXPERIMENT; ARTICLE; DEACETYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MALE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RAT; REACTION ANALYSIS; URINARY EXCRETION; XENOBIOTIC METABOLISM;

ANILIDES; ANILINE COMPOUNDS; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROLYSIS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MASS SPECTROMETRY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0032844758     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. Ehlhardt WJ and Howbert JJ (1991) Metabolism and disposition of p-chloroaniline in rat, mouse, and monkey. Drug Metab Dispos 19:366-369.
2. Green CR, Ham KN and Tange JD (1969) Kidney lesions induced in rats by p-aminophenol. Br Med J 1:162-164.
3. Lindon JC, Nicholson JK and Wilson ID (1996) Direct coupling of chromatographic separations to NMR spectroscopy. Prog NMR Spectrosc 29:1-49 and references cited therein.
4. Mutlib AE, Strupczewski JT and Chesson SM (1995) Application of hyphenated LC/NMR and LC/MS techniques in rapid identification of in vitro and in vivo metabolites of iloperidone. Drug Metab Dispos 23:951-964.
5. Nicholls AW, Farrant RD, Shockcor JP, Unger SE, Wilson ID, Lindon JC and Nicholson JK (1997a) NMR and HPLC-NMR spectroscopic studies on the metabolism and futile deacetylation in paracetamol metabolites in rat and man. Biochem Pharmacol 49:1155-1164.
6. Nicholls AW, Lindon JC, Caddick S, Farrant RD, Wilson ID and Nicholson JK (1997b) NMR spectroscopic studies on the metabolism and futile deacetylation of phenacetin in the rat. Xenobiotica 27:1175-1186.
7. Radomski JL (1979) The primary aromatic amines: Their biological properties and structure-activity relationships. Annu Rev Pharmacol Toxicol 19:129-157.
8. 19F NMR and directly coupled HPLC-NMR-MS investigations into the metabolism of 2-bromo-4-trifluoromethylaniline in the rat: A urinary excretion balance study without the use of radiolabelling. Xenobiotica 28:373-388.
9. 19F NMR spectroscopy and directly coupled HPLC-NMR-MS. Xenobiotica 29:77-92.
10. Shaka AJ, Keeler J and Freeman R (1983) Evaluation of a new broad band decoupler sequence: Waltz 16. J Magn Reson 53:313-340.
11. Tugnait M (1994) Multinuclear magnetic resonance studies on the metabolism of model fluoro-aromatic xenobiotics. Ph.D. Thesis, University of London.
12. Wade KE, Troke J, Macdonald CM, Wilson ID and Nicholson JK (1988) NMR studies of the metabolism of trifluoromethylaniline, in Bioanalysis of Drugs and Metabolites (Reid E, Robinson JD and Wilson ID eds) pp 383-388, Plenum Press, New York.
13. 14C-p-trifluoromethylaniline: Production of an oxanilic acid as the major metabolite by the rat. Biochem Pharmacol 34:2025-2028.