Selective alkylatation of dopamine D2 and D4 receptors in rat brain by N-(p-isothiocyanatophenethyl)spiperone

Neuroscience Letters

Volumn 274, Issue 3, 1999, Pages 155-158

  Zhang, Kehong ^a,b   Tarazi, Frank I ^a,b   Kula, Nora S ^a,b   Baldessarini, Ross J ^a,b   Neumeyer, John L ^a,b  

^a Mailman Research Center   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

1 Ethoxycarbonyl 2 ethoxy 1,2 dihydroquinoline; Alkylation; Autoradiography; Dopamine receptors; N (p isothiocyanatophenethyl)spiperone

Indexed keywords

1,3 BIS(2 METHYLPHENYL)GUANIDINE; 2 ETHOXY 1(2H) QUINOLINECARBOXYLIC ACID ETHYL ESTER; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ALKYLATING AGENT; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 4 RECEPTOR; EMONAPRIDE; FLUPENTIXOL; HALOPERIDOL; KETANSERIN; METHYSERGIDE; N (4 ISOTHIOCYANATOPHENETHYL)SPIPERONE; PINDOLOL; PRAZOSIN; RACLOPRIDE; SEROTONIN 2 RECEPTOR; SPIPERONE DERIVATIVE; SULPIRIDE; TRITIUM; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BRAIN; CAUDATE NUCLEUS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG SELECTIVITY; FOREBRAIN; GENETIC TRANSFECTION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RADIORECEPTOR ASSAY; RAT; RECEPTOR DENSITY;

ALKYLATION; ANIMALS; AUTORADIOGRAPHY; BRAIN CHEMISTRY; DOPAMINE ANTAGONISTS; MALE; NEOSTRIATUM; NUCLEUS ACCUMBENS; QUINOLINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; RECEPTORS, SEROTONIN; SPIPERONE;

EID: 0032844253     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(99)00700-4     Document Type: Article

References (20)

1. 2 antidopaminergic activity of alkylating and non-alkylating derivatives of spiperone in rat brain. Mol. Pharmacol. 42:1992;856-863.
2. Florijn W.J., Tarazi F.I., Creese I. Dopamine receptor subtypes: differential regulation after 8 months treatment with antipsychotic drugs. J. Pharmacol. Exp. Ther. 280:1997;561-569.
3. Gozlan H., Laporte A.M., Thibault S., Schlecter L., Bolanos F., Hamon M. Differential effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) on various 5-HT receptor binding sites in the rat brain. Neuropharmacology. 33:1994;423-431.
4. Hamblin M.W., Creese I. Behavioral and radioligand binding evidence for irreversible dopamine receptor blockade by N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. Life Sci. 32:1983;2247-2255.
5. Jibson M.D., Tandon R. New atypical antipsychotic medications. J. Psychiatr. Res. 32:1998;215-218.
6. Kebabian J.W., Tarazi F.I., Kula N.S., Baldessarini R.J. Compounds selective for dopamine receptor subtypes. Drug Discovery Today. 2:1997;333-340.
7. 4-selective dopamine receptor ligand. Eur. J. Pharmacol. 331:1997;333-336.
8. 3H]NGD 94-1 study. Mol. Psychiatry. 3:1998;528-533.
9. 3 dopamine receptor: neurobiology and potential clinical relevance. Pharmacol. Rev. 49:1997;231-252.
10. 2-imidazoline sites in vitro and in vivo. J. Neurochem. 61:1993;1602-1610.
11. 4 dopamine receptors in postmortem striatum from patients with schizophrenia. J. Neurosci. 15:1995;2186-2191.
12. Norman A., Creese I. Effects of in vivo and vitro treatments with N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline on putative muscarinic receptor subtypes in rat brain. Mol. Pharmacol. 30:1986;96-103.
13. 4 receptors elevated in schizophrenia. Nature. 261:1993;717-719.
14. 4 (DRD4) gene with a refined phenotype of attention deficit hyperactivity disorder (ADHD). Mol. Psychiatry. 3:1998;38-41.
15. 4 receptors: basic and clinical status. Int. J. Neuropsychopharmacol. 2:1999;41-58.
16. Tarazi F.I., Florijn W.J., Creese I. Differential regulation of dopamine receptors following chronic typical and atypical antipsychotic drug treatment. Neuroscience. 78:1997;985-996.
17. 4 receptors in rat forebrain. NeuroReport. 8:1997;3423-3426.
18. 4-like dopamine receptors. Neuropsychopharmacology. 17:1997;186-196.
19. 4 dopamine receptors: common targets for typical and atypical antipsychotic drugs. Prog. Neuro-Psychopharmacol. Biol. Psychiatry. 22:1998;693-707.
20. 3 receptors in rat brain: selective protection by dopamine. Brain Res. 1999;. in press.