Differential expression of mRNA in human thyroid cells depleted of mitochondrial DNA by ethidium bromide treatment

Clinical Science

Volumn 97, Issue 2, 1999, Pages 207-213

  Thomas, A W ^a   Majid, A ^b   Sherratt, E J ^b   Gagg, J W ^b   Alcolado, J C ^b  

^a CARDIFF METROPOLITAN UNIVERSITY   (United Kingdom)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Differential display; Ethidium bromide; Mitochondrial DNA; mRNA; Toxicity

Indexed keywords

ADENOSINE TRIPHOSPHATE; CARRIER PROTEIN; ENZYME INHIBITOR; ETHIDIUM BROMIDE; MESSENGER RNA; MITOCHONDRIAL DNA; THROMBOPLASTIN;

ARTICLE; CELL TRANSFORMATION; CLONE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE MUTATION; HUMAN; HUMAN CELL; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIMIAN VIRUS 40; THYROID CELL;

BLOTTING, NORTHERN; CELL LINE, TRANSFORMED; DNA, COMPLEMENTARY; DNA, MITOCHONDRIAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; ETHIDIUM; GENE EXPRESSION; HUMANS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; THYROID GLAND;

EID: 0032843960     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS19980400     Document Type: Article

References (28)

1. 1 Sherratt, E. J., Thomas, A. W. and Alcolado, J. C. (1997) Mitochondrial DNA defects: a widening clinical spectrum of disorders. Clin. Sci. 92, 225-235
2. 2 Ballinger, S. W., Shoffner, J. M., Hedaya, E. V. et al. (1992) Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion. Nat. Genet. 1, 11-15
3. 3 Van den Ouweland, J. M. W., Lemkes, H. H. P. J., Ruitenbeek, W. et al. (1992) Mutation in mitochondrial tRNAleu(UUR) in a large pedigree with maternally transmitted type II diabetes mellitus and deafness. Nat. Genet. 1, 368-371
4. 4 Alcolado, J. C., Majid, A., Brockington, M. et al. (1994) Mitochondrial gene defects in patients with NIDDM. Diabetologia 37, 372-376
5. 5 Goto, Y., Nonaka, I. and Horai, S. (1990) A mutation in the tRNAleu(UUR) gene associated with the MELAS subgroup of mitochondrial encephalomyopathies. Nature (London) 348, 651-652
6. 6 Wallace, D. C. (1992) Diseases of mitochondrial DNA. Annu. Rev. Biochem. 61, 1175-1212
7. 7 Reardon, W., Ross, R. J. M., Sweeney, M. G. et al. (1992) Diabetes mellitus associated with a pathogenic point mutation in mitochondrial DNA. Lancet 340, 1376-1379
8. 8 Holt, I. J., Miller, D. H. and Harding, A. E. (1991) Genetic heterogeneity and mitochondrial DNA heteroplasmy in Leber's hereditary optic neuropathy. J. Med. Genet. 26, 739-743
9. 9 Brown, M. D., Voljavec, A. S., Lott, M. T., Macdonald, I. and Wallace, D. C. (1995) Leber's hereditary optic neuropathy: a model for mitochondrial neurodegenerative diseases. FASEB J. 6, 2791-2799
10. 10 Zeviani, M. (1992) Nucleus-driven mutations of human mitochondrial DNA. J. Inher. Metab. Dis. 15, 455-471
11. 11 Jaehning, J. A. (1993) Mitochondrial transcription: is a pattern emerging? Mol. Microbiol. 8, 1-4
12. 12 Attardi, G., Chomyn, A., King, M. P., Kruse, B., Polosa, P. L. and Murdter, N. N. (1989) Regulation of mitochondrial gene expression in mammalian cells. Biochem. Soc. Trans. 18, 509-513
13. 13 Voos, W., Moczko, M. and Pfanner, N. (1994) Targeting, translocation and folding of mitochondrial preproteins. In Mitochondria, DNA, proteins and disease (Darley-Usmar, V. and Schapira, A. H. V., eds.), pp. 55-80, Portland Press, London
14. 14 Moraes, C. T., Shanske, S., Tritschler, H. J. et al. (1991) mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases. Am. J. Hum. Genet. 48, 492-501
15. 15 Tritshler, H. L., Andretta, F., Moraes, C. T. et al. (1991) Mitochondrial myopathy of childhood associated with depletion of mitochondrial DNA. Neurology 42, 209-217
16. 16 Zeviani, M., Servidei, S., Gellera, C., Bertini, E., DiMauro, S. and DiDonato, S. (1989) An autosomal dominant disorder with multiple deletions of mitochondrial DNA starting at the D-loop region. Nature (London) 339, 309-311
17. 17 Zeviani, M., Bresolin, N., Gellera, C. et al. (1990) Nucleus driven multiple large scale deletions of the human mitochondrial genome: a new autosomal disease. Am. J. Hum. Genet. 47, 904-914
18. 18 Yuzaki, M., Ohkoshi, N., Kanazawa, Y. and Ohta, S. (1989) Multiple deletions in mitochondrial DNA at direct repeats of non-D-loop regions in cases of familial mitochondrial myopathy. Biochem. Biophys. Res. Commun. 164, 1352-1357
19. 19 Parikh, V., Morgan, M. M., Scott, R., Clements, L. S. and Butow, R. A. (1987) The mitochondrial genotype can influence nuclear gene expression in yeast. Science 235, 576-580
20. 20 Wang, H. and Morais, R. (1997) Up-regulation of nuclear genes in response to inhibition of mitochondrial DNA expression in chicken cells. Biochim. Biophys. Acta 1352, 325-334
21. 21 King, M. P. and Attardi, G. (1989) Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 246, 500-503
22. 22 Liang, P. and Pardee, A. B. (1992) Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257, 967-971
23. 23 Lemoine, N. R., Mayall, E. S., Jones, T. et al. (1989) Characterisation of human thyroid cells immortalised in vitro by simian virus 40 DNA transfection. Br. J. Cancer 60, 897-903
24. 24 Bisbal, C., Martinand, C., Silhol, M., Lebleu, B. and Salehzada, T. (1995) Cloning and characterisation of a Rnase L inhibitor. A new component of the interferon-regulated 2-5 A pathway. J. Biol. Chem. 270, 13308-13317
25. 25 Hassel, B. A., Zhou, A., Sotomayor, C., Maran, A. and Silverman, R. H. (1993) A dominant negative mutant of 2-5A-dependent Rnase suppresses antiproliferative and antiviral effects of interferon. EMBO J. 12, 3297-3304
26. 26 Sen, G. C. and Lengyel, P. (1992) The interferon system. A bird's eye view of its biochemistry. J. Biol. Chem. 267, 5017-5020
27. 27 Radice, P., Pensotti, V., Jones, C., Perry, H., Pierotti, M. A. and Tunnacliffe, A. (1985) The human archain gene, ARCN1, has highly conserved homologs in rice and Drosophila. Genomics 26, 101-106
28. 28 Soejima, A., Inoue, K., Takai, D. et al. (1996) Mitochondrial DNA is required for regulation of glucose-stimulated insulin secretion in mouse pancreatic beta cell line, MIN6. J. Biol. Chem. 271, 26194-26199