The effect of baclofen on spontaneous and evoked behavioural expression of experimental neuropathic chronic pain

Arquivos de Neuro-Psiquiatria

Volumn 57, Issue 3 B, 1999, Pages 753-760

  Santos, Terezinha De Jesus T ^a   De Castro Costa, Carlos M ^b   Giffoni, Sílvio D A ^b   Santos, Franklin J C ^b   Ramos, Rodrigo S N ^b   Gifoni, Marcus A C ^b  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b NONE

Author keywords

Analgesia; Baclofen; Bennet's model; Experimental neuropathic pain; Scratching behaviour; Thermal stimulus

Indexed keywords

BACLOFEN; NALOXONE;

ALLODYNIA; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHRONIC PAIN; CONTROLLED STUDY; DRUG MECHANISM; MALE; NOCICEPTION; NONHUMAN; PERIPHERAL NEUROPATHY; RAT; SCIATIC NERVE; SCRATCHING; SPASTICITY; THERMAL STIMULATION; TRIGEMINUS NEURALGIA;

EID: 0032843590     PISSN: 0004282X     EISSN: None     Source Type: Journal    
DOI: 10.1590/s0004-282x1999000500005     Document Type: Article

References (30)

1. Terrence CF, Fromm GH, Tenicela R. Baclofen as an analgesic in chronic peripheral nerve disease. Eur Neurol 1985;24:380-385.
2. Taira T, Tanikavva T, Kawamura H et al. Spinal intrathecal baclofen suppresses central pain after a stroke. J Neurol Neurosurg Psychiatry 1994;57:381-386.
3. Anghinah R, Oliveira ASB, Gabbai AA. Effect of baclofen on pain in diabetic neuropathy. Muscle & Nerve 1994;17:958-959.
4. Herman RM, D'Luzansky SC, Ippolito R. Intrathecal baclofen suppresses central pain in patients with spinal lesions. Clin J Pain 1992;8:338-345.
5. Smith GD, Harrison SM, Birch PJ et al. Increased sensitivity to the antinociceptive activity of (±) baclofen in an animal model of chronic neuropathic, but not chronic inflammatory hyperalgesia. Neuropharmacology 1994;33:1103-1108.
6. Hammond DL, Nelson V, Thomas DA. Intrathecal methysergide antagonizes the antinociception, but not the hyperalgesia produced by microinjection of baclofen in the ventro-medial medulla of the rat. Neurosci Lett 1998;244:93-96.
7. Bennet GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988;33:87-107.
8. De Castro-Costa CM, De Sutter P, Gybels J et al. Adjuvant induced arthritis in rats: a possible animal model of chronic pain. Pain 1981;10:173-185.
9. Kupers R, Nuytten D, De Castro-Costa CM et al. A time course analysis of the spontaneous and evoked behaviour in a rat model of neuropathic pain. Pain 1992;50:101-111.
10. Attal N, Jazat F, Kayser V et al. Further evidences for pain-related behaviours in a model of unilateral peripheral mononeuropathy. Pain 1990;41:235-251.
11. IASP, Committee for Research and Ethical Issues. Ethical standards for investigation of experimental pain in animal. Pain 1983;16:109-110.
12. De Castro-Costa CM, Gybels J, Kupers R, et al. Scratching behaviour in arthritic rats: a sign of chronic pain or itch? Pain 1987;29:123-131.
13. Kupers R, Vos B, Gybels J. Stimulation of the nucleus paraventricularis thalami suppresses scratching and biting behaviour of arthritic rats and exerts a powerful effect on tests for acute pain. Pain 1988;32:115-125.
14. Alloisi AM, Porro CA, Cavazzuti M, et al. "Mirror pain" in the formalin test: behavioural and 2-deoxyglucose studies. Pain 1993;55:267-273.
15. Dobry PJK, Piercey MF, Schroeder I. Pharmacological characterization of scratching behavior induced by intracranial infection of substance P and somatostatin. Neuropharmacology 1981;20:267-272.
16. Schoenen J, Van Hess J, Gybels J, et al. Histochemical changes of substance P, FRAP, serotonin and succinic dehydrogenase in the spinal cord of rats with adjuvant arthritis. Life Sci 1985;36:1247-1254.
17. Idänpään-Heikkilä JJ, Guilbaud G. Pharmacological studies on a rat model of trigeminal neuropathic pain: baclofen, but not carbamazepine, morphine or tricyclic antidepressants, attenuates the allodynia-like behaviour. Pain 1999;79:281-290.
18. Castro-Lopes JM, Tavares I, Coimbra A. GABA decreases in the spinal cord dorsal horn after peripheral neurectomy. Brain Res 1993;620:287-291.
19. Saito K, Konish S, Otsuka M. Antagonism between lioresal and substance P in rat spinal cord. Brain Res 1975;97:177-180.
20. Fox S, Krnjevic K, Morris ME, et al. Action of baclofen on mammalian synaptic transmission. Neuroscience 1978;3:495-515.
21. Sawynok J, Reid A. Role of ascending and descending noradrenergic pathways in the antinociceptive effect of baclofen and clonidine. Brain Res 1986;386:341-350.
22. Kendal DA, Browner M, Enna SJ. Comparison of the antinociceptive effect of gamma-aminobutyric acid (GABA) agonists: evidence for a cholinergic involvement. J Pharmacol Exp Therap 1982;220:482-487.
23. Proudfit HK, Levy RA. Delimitation of neuronal substracts necessary for the analgesic action of baclofen and morphine. Eur J Pharmacol 1978;47:159-166.
24. Levy RA, Proudfit HK. Analgesia produced by microinjection of baclofen and morphine at brainstem sites. Eur J Pharmacol 1979;57:43-55.
25. Cui J-G, O'Connor WT, Ungerstedt U, et al. Spinal cord stimulation attenuates augmented dorsal horn release of excitatory aminoacids in mononeuropathy via a GABA-ergic mechanism. Pain 1997;53:87-95.
26. Buritova J, Chapman V, Honoré P, et al. The contribution of GABAB receptor-mediated events to inflammatory pain processing: carrageenan edema and associated spinal c-Fos expression in the rat. Neuroscience 1996;73:487-496.
27. Levy RA, Proudfit HK. The analgesic action of baclofen [BETA-(4-chlorophenyl) gamma-aminobutyric acid]. J Pharmacol Exp Therap 1977;202:437-445.
28. Baber NS, Dourish CT, Hill DR. The role of CCK, caerulein, and CCK antagonists in nociception. Pain 1989;39:307-328.
29. Cutting DA, Jordan CC. Alternative approaches to analgesia: baclofen as a model compound. Br J Pharmacol 1975;54:171-179.
30. Thomas DA, McGowan MK, Hammond DL. Microinjection of baclofen in the ventromedial medulla of rats: antinociception at low doses and hyperalgesia at high doses. J Pharmacol Exp Therap 1995;275:275-284.