β-Fibrinogen gene G/A-455 polymorphism in relation to fibrinogen concentrations and ischaemic heart disease in Chinese patients with Type II diabetes

Diabetologia

Volumn 42, Issue 10, 1999, Pages 1250-1253

  Lam, K S L ^a   Ma, O C K ^a   Wat, N M S ^a   Chan, L C ^a   Janus, E D ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Fibrinogen; Gene; Ischaemic heart disease; Polymorphism; Type II diabetes

Indexed keywords

FIBRINOGEN;

ADULT; AGED; ARTICLE; CHINESE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; FIBRINOGEN BLOOD LEVEL; GENE FREQUENCY; GENOTYPE; HUMAN; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; SEX DIFFERENCE; SMOKING;

AGE FACTORS; ALLELES; BODY MASS INDEX; CHINA; COHORT STUDIES; DIABETES MELLITUS, TYPE 2; FEMALE; FIBRINOGEN; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LINKAGE (GENETICS); LOGISTIC MODELS; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; POLYMORPHISM, GENETIC; RISK FACTORS; SEX FACTORS; SMOKING;

EID: 0032843432     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051300     Document Type: Article

References (10)

1. Ostermann H, van de Loo J (1986) Factors of the hemostatic system in diabetic patients. A survey of controlled studies. Haemostasis 16: 384-416
2. Ernst E (1993) The role of fibrinogen as a cardiovascular risk factor. Atherosclerosis 100: 1-12
3. Behague I, Poirier O, Nicaud V et al. (1996) β-Fibrinogen gene polymorphisms are associated with plasma fibrinogen and coronary artery disease in patients with myocardial infarction. The ECTIM study. Circulation 93: 440-449
4. Thomas AE, Green F, Lamlum H, Humphries S (1995) The association of combined alpha and beta fibrinogen genotype on plasma fibrinogen levels in smokers and non-smokers. J Med Genet 32: 585-589
5. Kessler C, Spitzer C, Stauske D et al. (1997) The apolipoprotein E and β-fibrinogen G/A-455 gene polymorphisms are associated with ischemic stroke involving large-vessel disease. Arterioscler Thromb Vase Biol 17: 2880-2884
6. Carter AM, Mansfield MW, Stickland MH, Grant PJ (1996) β-fibrinogen gene-455 G/A polymorphism and fibrinogen concentrations: risk factors for coronary artery disease in subjects with NIDDM. Diabetes Care 19: 1265-1268
7. -455-A β-gene) is asssociated with differences in plasma fibrinogen levels in young men and women from different regions in Europe: evidence for gender-genotype-environment interaction. Arterioscler Thromb Vasc Biol 15: 96-104
8. Lam KSL, Ma OCK, Bourke C, Chan LC, Janus ED (1998) Genetic influence of the R/Q353 genotype on factor VII activity is overwhelmed by environmental factors in Chinese patients with Type II (non-insulin-dependent) diabetes mellitus. Diabetologia 41: 760-766
9. -1689 (AvaII) and Bcl1 (β-fibrinogen) and Taq1 (a-fibrinogen), and their detection by PCR. Hum Mutat 3: 79-81
10. Nishiuma S, Kario K, Yakushijin K et al. (1998) Genetic variation in the promotor region of the beta-fibrinogen gene is associated with ischemic stroke in a Japanese population. Blood Coagul Fibrinolysis 9: 373-379