No role of interstitial adenosine in insulin-mediated vasodilation

Acta Physiologica Scandinavica

Volumn 167, Issue 1, 1999, Pages 37-42

  Dela, Flemming ^a   Stallknecht, B ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Blood flow; Microdialysis; Skeletal muscle; Spinal cord injured; Termodilution

Indexed keywords

ADENOSINE; INSULIN; NITRIC OXIDE;

ADULT; ARTICLE; CASE REPORT; CONTROLLED STUDY; EXTRACELLULAR FLUID; HUMAN; HYPERINSULINEMIA; LEG BLOOD FLOW; MALE; MUSCLE BLOOD FLOW; PRIORITY JOURNAL; SPINAL CORD INJURY; THERMODILUTION; VASODILATATION;

ADENOSINE; ADULT; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MUSCLE, SKELETAL; SPINAL CORD INJURIES; VASODILATION;

EID: 0032842760     PISSN: 00016772     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-201x.1999.00583.x     Document Type: Article

References (18)

1. Cunha, R.A. & Sebastiao, A.M. 1993. Adenosine and adenine nucleotides are independently released from both the nerve terminals and the muscle fibres upon electrical stimulation of the innervated skeletal muscle of the frog. Pflugers Arch - European J Physiol 424, 505-510.
2. Dela, F., Mikines, K.J., Linstow, V.M., Secher, N.H. & Galbo, H. 1992. Effect of training on insulin mediated glucose uptake in human skeletal muscle. Am J Physiol 263, E1134-E1143.
3. Dela, F., Larsen, J.J., Mikines, K.J. & Galbo, H. 1995a. Normal effect of insulin to stimulate leg blood flow in NIDDM. Diabetes 44, 221-226.
4. Dela, F., Mikines, K.J., Larsen, J.J., Ploug, T., Petersen, L.N. & Galbo, H. 1995b. Insulin stimulated muscle glucose clearance in patients with type 2 diabetes mellitus. Effects of one-legged physical training. Diabetes 44, 1010-1020.
5. Dela, F., Mikines, K.J., Larsen, J.J. & Galbo, H. 1996. Training induced enhancement of insulin action in human skeletal muscle: The influence of aging. J Gerontol 51A, B247-B252.
6. Frick, G.P. & Lowenstein, J.M. 1976. Studies of 5′-nucleotidase in the perfused rat heart. Including measurements of the enzyme in perfused skeletal muscle and liver. J Biol Chem 251, 6372-6378.
7. Han, D.-O., Hansen P., Nolte, L. & Holloszy, J.O. 1998. Removal of Adenosine decreases responsiveness of muscle glucose transport to insulin and contractions (Abstract). Diabetes 47, A271.
8. Hellsten, Y., MacLean, D.A., Radegran, G., Saltin, B. & Bangsbo, J. 1998. Adenosine concentrations in the interstitium of resting and contracting human skeletal muscle. Circulation 98, 6-8.
9. Leighton, B., Lozeman, F.J., Vlachonikolis, I.G., Challiss, R.A., Pitcher, J.A. & Newsholme, E.A. 1988. Effects of adenosine dearninase on the sensitivity of glucose transport, glycolysis and glycogen synthesis to insulin in muscles of the rat. Int J Biochem 20, 23-27.
10. Natali, A., Bonadonna, R., Santoro, D. et al. 1994. Insulin resistance and vasodilation in essential hypertension - Studies with adenosine. J Clin Invest 94, 1570-1576.
11. 2O, [18F]fluoro-2-deoxy-D-glucose, and positron emission tomography. Diabetes 45, 1471-1477.
12. Rubio, R., Berne, R.M. & Dobson, J.G., Jr 1973. Sites of adenosine production in cardiac and skeletal muscle. Am J Physiol 225, 938-953.
13. Schcrrer, U., Randin, D., Vollenweider, P., Vollenweider, L. & Nicod, P. 1994. Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest 94, 2511-2515.
14. Smits, P., Williams, S.B., Lipson, D.E., Banitt, P., Rongen, G.A. & Creager, M.A. 1995. Endothelial release of nitric oxide contributes to the vasodilator effect of adenosine in humans. Circulation 92, 2135-2141.
15. Stallknecht, B., Bülow, J., Frandsen, E. & Galbo, H. 1997. Desensitization of human adipose tissue to adrenaline stimulation studied by microdialysts. J Physiol (Lond) 500, 271-282.
16. Steinberg, H.O., Brechtel, G., Johnson, A., Fineberg, N. & Baron, A.D. 1994. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release. J Clin Invest 94, 1172-1179.
17. Vergauwen, L., Hespel, P. & Richter, E.A. 1994. Adenosine receptors mediate synergistic stimulation of glucose uptake and transport by insulin and by contractions in rat skeletal muscle. J Clin Invest 93, 974-981.
18. G-nitto-L-arginine methyl ester upon basal blood flow and endothelium-dependent vasodilatation in the dog hindlimb. Br J Pharmacol 108, 763-768.