Design criteria for molecular mimics of fragments of the β-turn. 2. Cα-Cβ bond vector analysis

Journal of Computer-Aided Molecular Design

Volumn 13, Issue 5, 1999, Pages 485-498

  Garland, S L ^a,b   Dean, P M ^b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Beta turn; Drug design; Molecular similarity; Peptidomimetics

Indexed keywords

VECTORS;

BETA TURNS; BOND VECTORS; CHAIN FRAGMENTS; DESIGN CRITERIA; DRUG DESIGN; MOLECULAR SIMILARITY; PEPTIDOMIMETICS; SIDE-CHAINS; THREE DIMENSIONS; VECTOR ANALYSIS;

CLUSTER ANALYSIS;

ARTICLE; MOLECULAR INTERACTION; MOLECULAR MIMICRY; PRIORITY JOURNAL; PROTEIN CONFORMATION; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING;

EID: 0032842085     PISSN: 0920654X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008014620568     Document Type: Article

References (31)

1. König, W., Peptide and Protein Hormones: Structure, Regulation, Activity, VCH, Weinheim, 1993.
2. Taylor, M.D. and Amidon, G.L. (Eds), Peptide-based Drug Design: Controlling Transport and Metabolism, ACS, Washington, DC, 1995.
3. Beck-Sickinger, A.G., Wieland, H.A., Wittneben, H., Willim, K.D., Rudolf, K. and Jung, G., Eur. J. Biochem., 225 (1994) 947.
4. Peeters, T.L., Macielag, M.J., Depoortere, I., Konteatis, Z., Vantrappen, G., Lessor, R. and Florance, J., Regul. Pept., 40 (1992) 226.
5. Tam, J.P., Liu, W., Zhang, J.-W., Galantino, M., Bertolero, F., Christiani, C., Vaghi, F. and de Castiglione, R., Peptides, 15 (1994) 703.
6. Kahn, M., Synlett, 11 (1993) 821.
7. Giannis, A. and Kolter, T., Angew. Chem. Int. Ed. Engl., 32 (1993) 1244.
8. Gante, J., Angew. Chem. Int. Ed. Engl., 33 (1994) 1699.
9. Damewood, J.R., Rev. Comp. Chem., 9 (1996) 1.
10. Goodman, M. and Ro, S., In Wolff, M.E. (Ed.) Burger's Medicinal Chemistry and Drug Discovery, Vol. 1, 1995, p. 803.
11. Wüthrich, K., NMR of Proteins and Nucleic Acids, John Wiley, New York, NY, 1991.
12. Fesik, S.W., Neri, P., Meadows, R., Olejniczak, E.T. and Gemmecker, G., J. Am. Chem. Soc., 114 (1992) 3165.
13. Weber, C., Weber, G., von Freyberg, B., Traber, R., Braun, W., Widmer, H. and Wüthrich, K., Biochemistry, 30 (1991) 6563.
14. Spitzfaden, C., Weber, H.P., Braun, W., Kallen, J., Wider, G., Widmer, H., Walkinshaw, M.D. and Wüthrich, K., FEBS Lett., 300 (1992) 291.
15. Veber, D.F., Freidinger, R.M., Perlow, D.S., Paleveda, W.J., Holly, F.W., Strachen, R.G., Nutt, R.F., Arison, B.H., Homnick, C., Randall, W.C., Glitzer, M.S., Saperstein, R. and Hirschmann, R., Nature, 292 (1981) 55.
16. Kopple, K.D., In Rieh, D.H. and Gross, E. (Eds.) Peptides: Synthesis, Structure, Function, Pierce Chemical Co., Rockford, IL, 1981, p. 295.
17. Momany, F.A., J. Am. Chem. Soc., 98 (1976) 2990.
18. Walter, R., Fed. Proc., 36 (1977) 1872.
19. Fox, J.W., Vavarek, R.J., Tu, A.T. and Stewart, J.M., Peptides, 1 (1982) 193.
20. Bradbury, A.F., Smythe, D.G. and Snell, C.R., Nature, 260 (1976) 165.
21. Rose, G.D., Gierasch, L.M. and Smith, J.A., Adv. Protein Chem., 37 (1985) 1.
22. Wilmot, C.M. and Thornton, J.M., J. Mol. Biol., 203 (1988) 221.
23. Wilmot, C.M. and Thornton, J.M., Protein Eng., 3 (1990) 479.
24. Ball, J.B., Hughes, R.A., Alewood, P.F. and Andrews, P.R., Tetrahedron, 49 (1993) 3467.
25. Farmer, P.S., In Ariens (Ed.) Drug Design, Vol. 10, Academic Press, New York, NY, 1980, pp. 119-143.
26. Garland, S.L. and Dean, P.M., J. Comput.-Aided Mol. Design, 13 (1999) 469.
27. SYBYL 6.4, 1997, Tripos Associates Inc., St. Louis, MO.
28. McLachlan, A.D., J. Mol. Biol., 128 (1979) 49.
29. Heisterberg, D.J., Ohio Supercomputer Center, Unpublished, 1990.
30. Ward, J.H., J. Am. Stat. Assoc., 58 (1963) 236.
31. Mojena, R., Comp. J., 20 (1977) 359.