Liquid chromatographic-tandem mass spectrometric method for the determination of the neuraminidase inhibitor zanamivir (GG167) in human serum

Journal of Chromatography B: Biomedical Sciences and Applications

Volumn 732, Issue 2, 1999, Pages 383-393

  Allen, G D ^a   Brookes, S T ^a   Barrow, A ^b   Dunn, J A ^c   Grosse, C M ^c  

^a Department of Mass Spectrometry   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c GLAXOSMITHKLINE   (United States)

Author keywords

LC MS MS; Neuraminidase inhibitor; Solid phase extraction; Zanamivir

Indexed keywords

SIALIDASE INHIBITOR; ZANAMIVIR;

ARTICLE; DRUG DETERMINATION; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN ANALYSIS; SOLID PHASE EXTRACTION;

ANIMALS; CALIBRATION; CHROMATOGRAPHY, LIQUID; ENZYME INHIBITORS; GUANIDINES; HUMANS; MASS SPECTROMETRY; NEURAMINIDASE; PYRANS; QUALITY CONTROL; RATS; REPRODUCIBILITY OF RESULTS; SIALIC ACIDS; ZANAMIVIR;

EID: 0032841733     PISSN: 13872273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4347(99)00306-0     Document Type: Article

References (9)

1. Waghorn S.L., Goa K.L. Drugs. 55:1998;721.
2. Hayden F.G., Osterhaus A.D.M.E., Treanor J.J., Fleming D.M., Aoki F.Y., Nicholson K.G., Bohnen A.M., Hirst H.M., Keene O., Wightman K. New Engl. J. Med. 337:1997;874.
3. Lancet. 352:1998;1877.
4. M.J. Daniel, A.J. Harker, R.D.M. Gray, Pre-clinical disposition studies of GG167, a novel anti-influenza agent. Poster presentation at the Options For The Control of Influenza, Third Symposium, Cairns, 1996.
5. Hayden F.G., Lobo M., Hussey E.K., Eason C.U. Brown L.E., Horton A.W., Webster R.G. Options for the Control of Influenza III. 1996;719 Elsevier, Oxford.
6. Stubbs R.J., Harker A.J. J. Chromatogr. B. 670:1995;279.
7. Brewer E., Henion J. J. Pharm. Sci. 87:1998;395.
8. Fu I., Woolf E.J., Matuszewski B.K. 8th International Symposium on Pharmaceutical and Biomedical Analysis :1997;. Abstract M/P-A9.
9. Matuszewski B.K., Constanzer M.L., Chavez-Eng C.M. Anal. Chem. 10:1998;882.